Gene Symbol: cdt-1
Description: CDT (S. pombe CDC10 Dependent Transcript) homolog
Alias: CDT (S. pombe CDC10 Dependent Transcript) homolog
Species: Caenorhabditis elegans
Biedermann B, Wright J, Senften M, Kalchhauser I, Sarathy G, Lee M, et al
. Translational repression of cyclin E prevents precocious mitosis and embryonic gene activation during C. elegans meiosis. Dev Cell. 2009;17:355-64 pubmed publisher
Zhong W, Feng H, Santiago F, Kipreos E. CUL-4 ubiquitin ligase maintains genome stability by restraining DNA-replication licensing. Nature. 2003;423:885-9 pubmed
..Removal of one genomic copy of cdt-1 suppresses the cul-4 re-replication phenotype. We propose that CUL-4 prevents aberrant re-initiation of DNA replication, at least in part, by facilitating the degradation of CDT-1. ..
Kim Y, Kipreos E. The Caenorhabditis elegans replication licensing factor CDT-1 is targeted for degradation by the CUL-4/DDB-1 complex. Mol Cell Biol. 2007;27:1394-406 pubmed
..We propose that the CUL-4/DDB-1 ubiquitin ligase is the principal E3 for regulating the extent of DNA replication in C. elegans. ..
Jia L, Bickel J, Wu J, Morgan M, Li H, Yang J, et al
. RBX1 (RING box protein 1) E3 ubiquitin ligase is required for genomic integrity by modulating DNA replication licensing proteins. J Biol Chem. 2011;286:3379-86 pubmed publisher
..RBX-1 silencing also induces lethality during development of embryos and in adulthood. Thus, RBX1 E3 ligase is essential for the maintenance of mammalian genome integrity and the proper development and viability in C. elegans. ..
Franz A, Orth M, Pirson P, Sonneville R, Blow J, Gartner A, et al
. CDC-48/p97 coordinates CDT-1 degradation with GINS chromatin dissociation to ensure faithful DNA replication. Mol Cell. 2011;44:85-96 pubmed publisher
..Moreover, our data confirmed a similar regulation in Xenopus egg extracts, emphasizing a conserved coordination of licensing and elongation events during eukaryotic DNA replication by CDC-48/p97. ..
Franz A, Pirson P, Pilger D, Halder S, Achuthankutty D, Kashkar H, et al
. Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression. Nat Commun. 2016;7:10612 pubmed publisher
..Our work identifies a critical substrate selection module of CDC-48/p97 required for chromatin-associated protein degradation in both Caenorhabditis elegans and humans, which is relevant to oncogenesis and aging. ..