Gene Symbol: cdk-8
Description: Cyclin-dependent kinase 8
Alias: Cyclin-dependent kinase 8
Species: Caenorhabditis elegans

Top Publications

  1. Clayton J, van den Heuvel S, Saito R. Transcriptional control of cell-cycle quiescence during C. elegans development. Dev Biol. 2008;313:603-13 pubmed
    ..These transcriptional regulators represent potential molecular connections between development and the basic cell-cycle machinery. ..
  2. Steimel A, Suh J, Hussainkhel A, Deheshi S, Grants J, Zapf R, et al. The C. elegans CDK8 Mediator module regulates axon guidance decisions in the ventral nerve cord and during dorsal axon navigation. Dev Biol. 2013;377:385-98 pubmed publisher
    ..This suggests that the CDK8 module specifically represses the SAX-3/ROBO pathway to ensure proper commissure navigation...
  3. Grants J, Ying L, Yoda A, You C, Okano H, Sawa H, et al. The Mediator Kinase Module Restrains Epidermal Growth Factor Receptor Signaling and Represses Vulval Cell Fate Specification in Caenorhabditis elegans. Genetics. 2016;202:583-99 pubmed publisher
    ..Here, we show that Mediator's dissociable cyclin dependent kinase 8 (CDK8) module (CKM), consisting of cdk-8, cic-1/Cyclin C, mdt-12/dpy-22, and mdt-13/let-19, is required ..