Gene Symbol: cdk-5
Description: Cyclin-dependent-like kinase 5
Alias: Cyclin-dependent-like kinase 5
Species: Caenorhabditis elegans
Locke C, Williams S, Schwarz E, Caldwell G, Caldwell K. Genetic interactions among cortical malformation genes that influence susceptibility to convulsions in C. elegans. Brain Res. 2006;1120:23-34 pubmed
..Thus, interactions among gene products with LIS-1 may mediate intrinsic thresholds of neuronal synchrony. ..
Juo P, Harbaugh T, Garriga G, Kaplan J. CDK-5 regulates the abundance of GLR-1 glutamate receptors in the ventral cord of Caenorhabditis elegans. Mol Biol Cell. 2007;18:3883-93 pubmed
..We propose that CDK-5 promotes the anterograde trafficking of GLR-1 and that phosphorylation of LIN-10 may play a role in this process. ..
Park M, Watanabe S, Poon V, Ou C, Jorgensen E, Shen K. CYY-1/cyclin Y and CDK-5 differentially regulate synapse elimination and formation for rewiring neural circuits. Neuron. 2011;70:742-57 pubmed publisher
Park E, GHOSE P, Shao Z, Ye Q, Kang L, Xu X, et al
. Hypoxia regulates glutamate receptor trafficking through an HIF-independent mechanism. EMBO J. 2012;31:1379-93 pubmed publisher
..Our findings demonstrate a novel mechanism by which neurons sense and respond to hypoxia. ..
Ou C, Poon V, Maeder C, Watanabe S, Lehrman E, Fu A, et al
. Two cyclin-dependent kinase pathways are essential for polarized trafficking of presynaptic components. Cell. 2010;141:846-58 pubmed publisher
..Thus, PCT-1 and CDK-5 pathways direct polarized trafficking of presynaptic components by inhibiting dynein-mediated retrograde transport and setting the balance between anterograde and retrograde motors. ..
Goodwin P, Sasaki J, Juo P. Cyclin-dependent kinase 5 regulates the polarized trafficking of neuropeptide-containing dense-core vesicles in Caenorhabditis elegans motor neurons. J Neurosci. 2012;32:8158-72 pubmed publisher
..We propose a model in which CDK-5 regulates DCV polarity by both promoting DCV trafficking in axons and preventing dynein-dependent DCV trafficking into dendrites. ..