Gene Symbol: cdk-5
Description: Cyclin-dependent-like kinase 5
Alias: Cyclin-dependent-like kinase 5
Species: Caenorhabditis elegans

Top Publications

  1. Locke C, Williams S, Schwarz E, Caldwell G, Caldwell K. Genetic interactions among cortical malformation genes that influence susceptibility to convulsions in C. elegans. Brain Res. 2006;1120:23-34 pubmed
    ..Thus, interactions among gene products with LIS-1 may mediate intrinsic thresholds of neuronal synchrony. ..
  2. Juo P, Harbaugh T, Garriga G, Kaplan J. CDK-5 regulates the abundance of GLR-1 glutamate receptors in the ventral cord of Caenorhabditis elegans. Mol Biol Cell. 2007;18:3883-93 pubmed
    ..We propose that CDK-5 promotes the anterograde trafficking of GLR-1 and that phosphorylation of LIN-10 may play a role in this process. ..
  3. Park M, Watanabe S, Poon V, Ou C, Jorgensen E, Shen K. CYY-1/cyclin Y and CDK-5 differentially regulate synapse elimination and formation for rewiring neural circuits. Neuron. 2011;70:742-57 pubmed publisher
  4. Park E, GHOSE P, Shao Z, Ye Q, Kang L, Xu X, et al. Hypoxia regulates glutamate receptor trafficking through an HIF-independent mechanism. EMBO J. 2012;31:1379-93 pubmed publisher
    ..Our findings demonstrate a novel mechanism by which neurons sense and respond to hypoxia. ..
  5. Ou C, Poon V, Maeder C, Watanabe S, Lehrman E, Fu A, et al. Two cyclin-dependent kinase pathways are essential for polarized trafficking of presynaptic components. Cell. 2010;141:846-58 pubmed publisher
    ..Thus, PCT-1 and CDK-5 pathways direct polarized trafficking of presynaptic components by inhibiting dynein-mediated retrograde transport and setting the balance between anterograde and retrograde motors. ..
  6. Goodwin P, Sasaki J, Juo P. Cyclin-dependent kinase 5 regulates the polarized trafficking of neuropeptide-containing dense-core vesicles in Caenorhabditis elegans motor neurons. J Neurosci. 2012;32:8158-72 pubmed publisher
    ..We propose a model in which CDK-5 regulates DCV polarity by both promoting DCV trafficking in axons and preventing dynein-dependent DCV trafficking into dendrites. ..