Gene Symbol: cdk-1
Description: Cyclin-dependent kinase 1
Alias: Cyclin-dependent kinase 1
Species: Caenorhabditis elegans
Products:     cdk-1

Top Publications

  1. Hajeri V, Little B, Ladage M, Padilla P. NPP-16/Nup50 function and CDK-1 inactivation are associated with anoxia-induced prophase arrest in Caenorhabditis elegans. Mol Biol Cell. 2010;21:712-24 pubmed publisher
    ..elegans embryos. The anoxia-induced shift of cells from an actively dividing state to an arrested state reveals a previously uncharacterized prophase checkpoint in the C. elegans embryo. ..
  2. Chase D, Serafinas C, Ashcroft N, Kosinski M, Longo D, Ferris D, et al. The polo-like kinase PLK-1 is required for nuclear envelope breakdown and the completion of meiosis in Caenorhabditis elegans. Genesis. 2000;26:26-41 pubmed
    ..These defects led to embryonic arrest as single cells. genesis 26:26-41, 2000. Published 2000 Wiley-Liss, Inc. ..
  3. Shirayama M, Soto M, Ishidate T, Kim S, Nakamura K, Bei Y, et al. The Conserved Kinases CDK-1, GSK-3, KIN-19, and MBK-2 Promote OMA-1 Destruction to Regulate the Oocyte-to-Embryo Transition in C. elegans. Curr Biol. 2006;16:47-55 pubmed
  4. Burrows A, Sceurman B, Kosinski M, Richie C, Sadler P, Schumacher J, et al. The C. elegans Myt1 ortholog is required for the proper timing of oocyte maturation. Development. 2006;133:697-709 pubmed
    ..Furthermore, co-depletion studies of CDK-1 and WEE-1.3 demonstrate that WEE-1.3 is dispensable in the absence of CDK-1, suggesting that CDK-1 is a major target of WEE-1.3 in C. elegans oocytes. ..
  5. Boxem M, Srinivasan D, van den Heuvel S. The Caenorhabditis elegans gene ncc-1 encodes a cdc2-related kinase required for M phase in meiotic and mitotic cell divisions, but not for S phase. Development. 1999;126:2227-39 pubmed
    ..Our results indicate that C. elegans uses multiple Cdks to regulate cell-cycle transitions and that ncc-1 is the C. elegans ortholog of Cdk1/Cdc2 in other metazoans, required for M phase in meiotic as well as mitotic cell cycles. ..
  6. van der Voet M, Lorson M, Srinivasan D, Bennett K, van den Heuvel S. C. elegans mitotic cyclins have distinct as well as overlapping functions in chromosome segregation. Cell Cycle. 2009;8:4091-102 pubmed
  7. Thomas Y, Cirillo L, Panbianco C, Martino L, Tavernier N, Schwager F, et al. Cdk1 Phosphorylates SPAT-1/Bora to Promote Plk1 Activation in C. elegans and Human Cells. Cell Rep. 2016;15:510-518 pubmed publisher
    ..Our results reveal a crucial and conserved role of phosphorylation of the N terminus of Bora for Plk1 activation and mitotic entry. ..
  8. Kim S, Ishidate T, Sharma R, Soto M, Conte D, Mello C, et al. Wnt and CDK-1 regulate cortical release of WRM-1/?-catenin to control cell division orientation in early Caenorhabditis elegans embryos. Proc Natl Acad Sci U S A. 2013;110:E918-27 pubmed publisher
    ..Our findings are consistent with a model in which Wnt signaling and CDK-1 modify WRM-1 in a temporal and spatial manner to unmask an intrinsic polarity cue required for proper orientation of the EMS cell division axis. ..
  9. Cheng K, Klancer R, Singson A, Seydoux G. Regulation of MBK-2/DYRK by CDK-1 and the pseudophosphatases EGG-4 and EGG-5 during the oocyte-to-embryo transition. Cell. 2009;139:560-72 pubmed publisher
    ..Our findings link cell-cycle progression to MBK-2/DYRK activation and the oocyte-to-embryo transition. ..

More Information


  1. Park M, Watanabe S, Poon V, Ou C, Jorgensen E, Shen K. CYY-1/cyclin Y and CDK-5 differentially regulate synapse elimination and formation for rewiring neural circuits. Neuron. 2011;70:742-57 pubmed publisher
  2. Poteryaev D, Squirrell J, Campbell J, White J, Spang A. Involvement of the actin cytoskeleton and homotypic membrane fusion in ER dynamics in Caenorhabditis elegans. Mol Biol Cell. 2005;16:2139-53 pubmed
    ..Both proteins have been implicated in homotypic ER membrane fusion. We provide evidence that homotypic membrane fusion is required to form the sheet structure in the early embryo. ..
  3. Rabilotta A, Desrosiers M, Labbé J. CDK-1 and two B-type cyclins promote PAR-6 stabilization during polarization of the early C. elegans embryo. PLoS ONE. 2015;10:e0117656 pubmed publisher
    ..elegans embryo. They also suggest that CYB-2.1 and CYB-2.2 contribute to the coupling of cell cycle progression and asymmetric segregation of cell fate determinants. ..
  4. Tavernier N, Noatynska A, Panbianco C, Martino L, Van Hove L, Schwager F, et al. Cdk1 phosphorylates SPAT-1/Bora to trigger PLK-1 activation and drive mitotic entry in C. elegans embryos. J Cell Biol. 2015;208:661-9 pubmed publisher
    ..We propose the existence of a positive feedback loop that connects Cdk1 and Plk1 activation to ensure a robust control of mitotic entry and cell division timing. ..
  5. Yang R, Feldman J. SPD-2/CEP192 and CDK Are Limiting for Microtubule-Organizing Center Function at the Centrosome. Curr Biol. 2015;25:1924-31 pubmed publisher
    ..We show that conversion of MTOC state involves the conserved centrosome protein SPD-2/CEP192 and CDK activity from the mitotic cell. ..
  6. Ellefson M, McNally F. CDK-1 inhibits meiotic spindle shortening and dynein-dependent spindle rotation in C. elegans. J Cell Biol. 2011;193:1229-44 pubmed publisher
    ..These results suggest that CDK-1 blocks rotation by inhibiting dynein association with microtubules and with LIN-5-ASPM-1 at meiotic spindle poles and that the APC promotes spindle rotation by inhibiting CDK-1. ..
  7. Tavernier N, Panbianco C, Gotta M, Pintard L. Cdk1 plays matchmaker for the Polo-like kinase and its activator SPAT-1/Bora. Cell Cycle. 2015;14:2394-8 pubmed publisher
    ..These results indicate that Cdk1 regulates Plk1 by boosting its kinase activity. Here we discuss these recent findings and open questions regarding the regulation of Plk1/PLK-1 by Cdk1/CDK-1 and Bora/SPAT-1. ..
  8. Seidel H, Kimble J. Cell-cycle quiescence maintains Caenorhabditis elegans germline stem cells independent of GLP-1/Notch. elife. 2015;4: pubmed publisher
    ..Thus, cell-cycle quiescence can itself maintain stem cells, independent of the signaling pathway otherwise essential for such maintenance. ..
  9. Yoon S, Kawasaki I, Shim Y. CDC-25.1 controls the rate of germline mitotic cell cycle by counteracting WEE-1.3 and by positively regulating CDK-1 in Caenorhabditis elegans. Cell Cycle. 2012;11:1354-63 pubmed publisher
    ..We propose that CDC-25.1 regulates the rate of germline mitotic cell cycle by counteracting WEE-1.3 and by positively controlling CDK-1, which forms a complex primarily with CYB-3, but also possibly with CYD-1 and CYE-1. ..
  10. Wallenfang M, Seydoux G. cdk-7 Is required for mRNA transcription and cell cycle progression in Caenorhabditis elegans embryos. Proc Natl Acad Sci U S A. 2002;99:5527-32 pubmed
    ..Our results support a dual role for metazoan CDK7 as a broadly required CTD kinase, and as a CAK essential for cell cycle progression. ..