Gene Symbol: cdc-48.2
Description: Transitional endoplasmic reticulum ATPase homolog 2
Alias: Transitional endoplasmic reticulum ATPase homolog 2
Species: Caenorhabditis elegans

Top Publications

  1. Sasagawa Y, Yamanaka K, Nishikori S, Ogura T. Caenorhabditis elegans p97/CDC-48 is crucial for progression of meiosis I. Biochem Biophys Res Commun. 2007;358:920-4 pubmed
    ..Furthermore, we found that chromosome condensation was significantly reduced in p97-depleted oocytes. Taken these results altogether, we propose that C. elegans p97 plays an important role in the progression of meiosis. ..
  2. Mouysset J, Deichsel A, Moser S, Hoege C, Hyman A, Gartner A, et al. Cell cycle progression requires the CDC-48UFD-1/NPL-4 complex for efficient DNA replication. Proc Natl Acad Sci U S A. 2008;105:12879-84 pubmed publisher
    ..Our findings identified a role for CDC-48(UFD-1/NPL-4) in DNA replication, which is important for cell cycle progression and genome stability. ..
  3. Rodrigues A, Neves Carvalho A, Ferro A, Rokka A, Corthals G, Logarinho E, et al. ATX-3, CDC-48 and UBXN-5: a new trimolecular complex in Caenorhabditis elegans. Biochem Biophys Res Commun. 2009;386:575-81 pubmed publisher
    ..Additionally, we describe several common interactors of ATX-3 and UBXN-5, some of which can be in vivo targets of this complex. ..
  4. Sasagawa Y, Yamanaka K, Ogura T. ER E3 ubiquitin ligase HRD-1 and its specific partner chaperone BiP play important roles in ERAD and developmental growth in Caenorhabditis elegans. Genes Cells. 2007;12:1063-73 pubmed
    ..We propose that E3 ubiquitin ligases function in concert with a specific partner chaperone. ..
  5. Ramadan K, Bruderer R, Spiga F, Popp O, Baur T, Gotta M, et al. Cdc48/p97 promotes reformation of the nucleus by extracting the kinase Aurora B from chromatin. Nature. 2007;450:1258-62 pubmed
    ..These data reveal an essential pathway that regulates reformation of the nucleus after mitosis and defines ubiquitin-dependent protein extraction as a common mechanism of Cdc48/p97 activity also during nucleus formation. ..
  6. Nishikori S, Yamanaka K, Sakurai T, Esaki M, Ogura T. p97 Homologs from Caenorhabditis elegans, CDC-48.1 and CDC-48.2, suppress the aggregate formation of huntingtin exon1 containing expanded polyQ repeat. Genes Cells. 2008;13:827-38 pubmed publisher
    ..1 and CDC-48.2. Taken together, these results suggest that p97 plays a protective role in neurodegenerative disorders by directly suppressing the protein aggregation as a molecular chaperone. ..
  7. Poteryaev D, Squirrell J, Campbell J, White J, Spang A. Involvement of the actin cytoskeleton and homotypic membrane fusion in ER dynamics in Caenorhabditis elegans. Mol Biol Cell. 2005;16:2139-53 pubmed
    ..Both proteins have been implicated in homotypic ER membrane fusion. We provide evidence that homotypic membrane fusion is required to form the sheet structure in the early embryo. ..
  8. Mouysset J, Kähler C, Hoppe T. A conserved role of Caenorhabditis elegans CDC-48 in ER-associated protein degradation. J Struct Biol. 2006;156:41-9 pubmed
    ..Together, these data suggest an evolutionarily conserved retro-translocation machinery at the endoplasmic reticulum. ..
  9. Kuhlbrodt K, Janiesch P, Kevei E, Segref A, Barikbin R, Hoppe T. The Machado-Joseph disease deubiquitylase ATX-3 couples longevity and proteostasis. Nat Cell Biol. 2011;13:273-81 pubmed publisher

More Information


  1. Yamanaka K, Okubo Y, Suzaki T, Ogura T. Analysis of the two p97/VCP/Cdc48p proteins of Caenorhabditis elegans and their suppression of polyglutamine-induced protein aggregation. J Struct Biol. 2004;146:242-50 pubmed
    ..The formation of aggregates was partially suppressed by co-expression of either C41C4.8 or C06A1.1. These results suggest that these p97/VCP/Cdc48p homologues, AAA chaperones, may play a protective role in polyQ aggregation. ..
  2. Janiesch P, Kim J, Mouysset J, Barikbin R, Lochmuller H, Cassata G, et al. The ubiquitin-selective chaperone CDC-48/p97 links myosin assembly to human myopathy. Nat Cell Biol. 2007;9:379-90 pubmed
  3. Boxem M, Maliga Z, Klitgord N, Li N, Lemmens I, Mana M, et al. A protein domain-based interactome network for C. elegans early embryogenesis. Cell. 2008;134:534-45 pubmed publisher
    ..This interactome modeling strategy revealed insights into C. elegans centrosome function and is applicable to other biological processes in this and other organisms. ..
  4. Heallen T, Adams H, Furuta T, Verbrugghe K, Schumacher J. An Afg2/Spaf-related Cdc48-like AAA ATPase regulates the stability and activity of the C. elegans Aurora B kinase AIR-2. Dev Cell. 2008;15:603-16 pubmed publisher
  5. Sasagawa Y, Yamanaka K, Saito Sasagawa Y, Ogura T. Caenorhabditis elegans UBX cofactors for CDC-48/p97 control spermatogenesis. Genes Cells. 2010;15:1201-15 pubmed publisher
    ..Taken together, these results suggest that UBXN-1, UBXN-2 and UBXN-3 are redundant cofactors for CDC-48/p97 and control spermatogenesis via the degradation of TRA-1A. ..