Gene Symbol: cdc-48.1
Description: Transitional endoplasmic reticulum ATPase homolog 1
Alias: Transitional endoplasmic reticulum ATPase homolog 1
Species: Caenorhabditis elegans

Top Publications

  1. Poteryaev D, Squirrell J, Campbell J, White J, Spang A. Involvement of the actin cytoskeleton and homotypic membrane fusion in ER dynamics in Caenorhabditis elegans. Mol Biol Cell. 2005;16:2139-53 pubmed
    ..Both proteins have been implicated in homotypic ER membrane fusion. We provide evidence that homotypic membrane fusion is required to form the sheet structure in the early embryo. ..
  2. Sasagawa Y, Yamanaka K, Nishikori S, Ogura T. Caenorhabditis elegans p97/CDC-48 is crucial for progression of meiosis I. Biochem Biophys Res Commun. 2007;358:920-4 pubmed
    ..Furthermore, we found that chromosome condensation was significantly reduced in p97-depleted oocytes. Taken these results altogether, we propose that C. elegans p97 plays an important role in the progression of meiosis. ..
  3. Sasagawa Y, Yamanaka K, Ogura T. ER E3 ubiquitin ligase HRD-1 and its specific partner chaperone BiP play important roles in ERAD and developmental growth in Caenorhabditis elegans. Genes Cells. 2007;12:1063-73 pubmed
    ..We propose that E3 ubiquitin ligases function in concert with a specific partner chaperone. ..
  4. Caruso M, Jenna S, Bouchecareilh M, Baillie D, Boismenu D, Halawani D, et al. GTPase-mediated regulation of the unfolded protein response in Caenorhabditis elegans is dependent on the AAA+ ATPase CDC-48. Mol Cell Biol. 2008;28:4261-74 pubmed publisher
    ..In addition, we describe a novel signaling module involving CRP-1 and CDC-48 which may directly link the UPR to DNA remodeling and transcription control. ..
  5. Nishikori S, Yamanaka K, Sakurai T, Esaki M, Ogura T. p97 Homologs from Caenorhabditis elegans, CDC-48.1 and CDC-48.2, suppress the aggregate formation of huntingtin exon1 containing expanded polyQ repeat. Genes Cells. 2008;13:827-38 pubmed publisher
    ..1 and CDC-48.2. Taken together, these results suggest that p97 plays a protective role in neurodegenerative disorders by directly suppressing the protein aggregation as a molecular chaperone. ..
  6. Yamanaka K, Okubo Y, Suzaki T, Ogura T. Analysis of the two p97/VCP/Cdc48p proteins of Caenorhabditis elegans and their suppression of polyglutamine-induced protein aggregation. J Struct Biol. 2004;146:242-50 pubmed
    ..The formation of aggregates was partially suppressed by co-expression of either C41C4.8 or C06A1.1. These results suggest that these p97/VCP/Cdc48p homologues, AAA chaperones, may play a protective role in polyQ aggregation. ..
  7. Janiesch P, Kim J, Mouysset J, Barikbin R, Lochmuller H, Cassata G, et al. The ubiquitin-selective chaperone CDC-48/p97 links myosin assembly to human myopathy. Nat Cell Biol. 2007;9:379-90 pubmed
  8. Marza E, Taouji S, Barroso K, Raymond A, Guignard L, Bonneu M, et al. Genome-wide screen identifies a novel p97/CDC-48-dependent pathway regulating ER-stress-induced gene transcription. EMBO Rep. 2015;16:332-40 pubmed publisher
    ..Together, these results describe a novel role for p97/CDC-48, whereby its role in protein degradation is integrated with its role in regulating expression of ER stress response genes. ..
  9. Rodrigues A, Neves Carvalho A, Ferro A, Rokka A, Corthals G, Logarinho E, et al. ATX-3, CDC-48 and UBXN-5: a new trimolecular complex in Caenorhabditis elegans. Biochem Biophys Res Commun. 2009;386:575-81 pubmed publisher
    ..Additionally, we describe several common interactors of ATX-3 and UBXN-5, some of which can be in vivo targets of this complex. ..

More Information


  1. Nishikori S, Esaki M, Yamanaka K, Sugimoto S, Ogura T. Positive cooperativity of the p97 AAA ATPase is critical for essential functions. J Biol Chem. 2011;286:15815-20 pubmed publisher
    ..Interestingly, the growth speed of yeast cells strongly related to the positive cooperativity rather than the ATPase activity itself, suggesting that the positive cooperativity is critical for the essential functions of p97. ..
  2. Ramadan K, Bruderer R, Spiga F, Popp O, Baur T, Gotta M, et al. Cdc48/p97 promotes reformation of the nucleus by extracting the kinase Aurora B from chromatin. Nature. 2007;450:1258-62 pubmed
    ..These data reveal an essential pathway that regulates reformation of the nucleus after mitosis and defines ubiquitin-dependent protein extraction as a common mechanism of Cdc48/p97 activity also during nucleus formation. ..
  3. Yamauchi S, Higashitani N, Otani M, Higashitani A, Ogura T, Yamanaka K. Involvement of HMG-12 and CAR-1 in the cdc-48.1 expression of Caenorhabditis elegans. Dev Biol. 2008;318:348-59 pubmed publisher
    ..Importantly, we found the decreased expression of p97 in embryos prepared from hmg-12(RNAi) or car-1(RNAi) worms. These results indicate that both HMG-12 and CAR-1 play important roles in embryonic expression of cdc-48.1. ..
  4. Sasagawa Y, Higashitani A, Urano T, Ogura T, Yamanaka K. CDC-48/p97 is required for proper meiotic chromosome segregation via controlling AIR-2/Aurora B kinase localization in Caenorhabditis elegans. J Struct Biol. 2012;179:104-11 pubmed publisher
    ..However, the amount and localization of PP1 were not changed by the depletion of CDC-48s. These results suggest that CDC-48s control the restricted localization of AIR-2 to the cohesion sites of homologous chromatids in meiosis I. ..
  5. Segref A, Torres S, Hoppe T. A screenable in vivo assay to study proteostasis networks in Caenorhabditis elegans. Genetics. 2011;187:1235-40 pubmed publisher
  6. Franz A, Pirson P, Pilger D, Halder S, Achuthankutty D, Kashkar H, et al. Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression. Nat Commun. 2016;7:10612 pubmed publisher
    ..Our work identifies a critical substrate selection module of CDC-48/p97 required for chromatin-associated protein degradation in both Caenorhabditis elegans and humans, which is relevant to oncogenesis and aging. ..
  7. Noi K, Yamamoto D, Nishikori S, Arita Morioka K, Kato T, Ando T, et al. High-speed atomic force microscopic observation of ATP-dependent rotation of the AAA+ chaperone p97. Structure. 2013;21:1992-2002 pubmed publisher
    ..In the presence of ATP, the N-D1 ring repeatedly rotates ~23 ± 8° clockwise and resets relative to the D2 ring. Mutational analysis reveals that this rotation is induced by ATP binding to the D2 domain...
  8. Mouysset J, Deichsel A, Moser S, Hoege C, Hyman A, Gartner A, et al. Cell cycle progression requires the CDC-48UFD-1/NPL-4 complex for efficient DNA replication. Proc Natl Acad Sci U S A. 2008;105:12879-84 pubmed publisher
    ..Our findings identified a role for CDC-48(UFD-1/NPL-4) in DNA replication, which is important for cell cycle progression and genome stability. ..
  9. Sasagawa Y, Yamanaka K, Saito Sasagawa Y, Ogura T. Caenorhabditis elegans UBX cofactors for CDC-48/p97 control spermatogenesis. Genes Cells. 2010;15:1201-15 pubmed publisher
    ..Taken together, these results suggest that UBXN-1, UBXN-2 and UBXN-3 are redundant cofactors for CDC-48/p97 and control spermatogenesis via the degradation of TRA-1A. ..
  10. Sasagawa Y, Otani M, Higashitani N, Higashitani A, Sato K, Ogura T, et al. Caenorhabditis elegans p97 controls germline-specific sex determination by controlling the TRA-1 level in a CUL-2-dependent manner. J Cell Sci. 2009;122:3663-72 pubmed publisher
    ..Our results demonstrate that the C. elegans p97/CDC-48-UFD-1-NPL-4 complex controls the sperm-oocyte switch by regulating CUL-2-mediated TRA-1A proteasome degradation. ..
  11. Heallen T, Adams H, Furuta T, Verbrugghe K, Schumacher J. An Afg2/Spaf-related Cdc48-like AAA ATPase regulates the stability and activity of the C. elegans Aurora B kinase AIR-2. Dev Cell. 2008;15:603-16 pubmed publisher
  12. Mouysset J, Kähler C, Hoppe T. A conserved role of Caenorhabditis elegans CDC-48 in ER-associated protein degradation. J Struct Biol. 2006;156:41-9 pubmed
    ..Together, these data suggest an evolutionarily conserved retro-translocation machinery at the endoplasmic reticulum. ..
  13. Kuhlbrodt K, Janiesch P, Kevei E, Segref A, Barikbin R, Hoppe T. The Machado-Joseph disease deubiquitylase ATX-3 couples longevity and proteostasis. Nat Cell Biol. 2011;13:273-81 pubmed publisher