Gene Symbol: cbp-1
Description: Protein cbp-1
Alias: Protein cbp-1
Species: Caenorhabditis elegans

Top Publications

  1. Victor M, Bei Y, Gay F, Calvo D, Mello C, Shi Y. HAT activity is essential for CBP-1-dependent transcription and differentiation in Caenorhabditis elegans. EMBO Rep. 2002;3:50-5 pubmed
    ..Our findings demonstrate that HAT activity is of primary importance for CBP-1 to regulate transcription and to promote differentiation during C. elegans embryogenesis. ..
  2. Shi Y, Mello C. A CBP/p300 homolog specifies multiple differentiation pathways in Caenorhabditis elegans. Genes Dev. 1998;12:943-55 pubmed
    ..Our findings suggest a model in which CBP-1 may activate transcription and differentiation in C. elegans by directly or indirectly antagonizing a repressive effect of histone deacetylase. ..
  3. Eastburn D, Han M. A gain-of-function allele of cbp-1, the Caenorhabditis elegans ortholog of the mammalian CBP/p300 gene, causes an increase in histone acetyltransferase activity and antagonism of activated Ras. Mol Cell Biol. 2005;25:9427-34 pubmed
    ..To our knowledge, this is the only such HAT activity mutation isolated in a CBP/p300 family protein, and this mutation may define a negative role of the HAT activity in antagonizing Ras function in a specific developmental event. ..
  4. Zhang M, Poplawski M, Yen K, Cheng H, Bloss E, Zhu X, et al. Role of CBP and SATB-1 in aging, dietary restriction, and insulin-like signaling. PLoS Biol. 2009;7:e1000245 pubmed publisher
    ..Other factors implicated in lifespan extension are also CBP-binding partners, suggesting that CBP constitutes a common factor in the modulation of lifespan and disease burden by DR and the insulin/IGF1 signaling pathway. ..
  5. Lundblad J, Kwok R, Laurance M, Harter M, Goodman R. Adenoviral E1A-associated protein p300 as a functional homologue of the transcriptional co-activator CBP. Nature. 1995;374:85-8 pubmed
    ..Our results indicate that the gene repression and cell immortalization functions associated with E1A involve the inactivation of a family of related proteins that normally participate in second-messenger-regulated gene expression. ..
  6. Calvo D, Victor M, Gay F, Sui G, Luke M, Dufourcq P, et al. A POP-1 repressor complex restricts inappropriate cell type-specific gene transcription during Caenorhabditis elegans embryogenesis. EMBO J. 2001;20:7197-208 pubmed
    ..Furthermore, they identify a strategy by which concerted actions of histone deacetylases and other co-repressors ensure maximal repression of inappropriate cell type-specific gene transcription. ..
  7. Kimura Y, Corcoran E, Eto K, Gengyo Ando K, Muramatsu M, Kobayashi R, et al. A CaMK cascade activates CRE-mediated transcription in neurons of Caenorhabditis elegans. EMBO Rep. 2002;3:962-6 pubmed
    ..Utilizing a transgenic approach to visualize CREB-dependent transcription in vivo, we show that this CaMK cascade regulates CRE-mediated transcription in a subset of head neurons in living nematodes. ..
  8. Gay F, Calvo D, Lo M, Ceron J, Maduro M, Lin R, et al. Acetylation regulates subcellular localization of the Wnt signaling nuclear effector POP-1. Genes Dev. 2003;17:717-22 pubmed
    ..elegans embryogenesis. The conservation of these lysines among other LEF/TCF family members suggests that acetylation may be an important, evolutionarily conserved mechanism regulating subcellular distribution of LEF/TCF factors. ..
  9. Jo H, Shim J, Lee J, Lee J, Kim J. IRE-1 and HSP-4 contribute to energy homeostasis via fasting-induced lipases in C. elegans. Cell Metab. 2009;9:440-8 pubmed publisher
    ..These data suggest that the ER-resident proteins IRE-1 and HSP-4 are key nutritional sensors that modulate expression of inducible lipases to maintain whole-body energy homeostasis in C. elegans. ..

More Information


  1. Shibata Y, Takeshita H, Sasakawa N, Sawa H. Double bromodomain protein BET-1 and MYST HATs establish and maintain stable cell fates in C. elegans. Development. 2010;137:1045-53 pubmed publisher
    ..Our results therefore indicate that histone acetylation plays a crucial role in cell-fate maintenance. ..
  2. Luitjens C, Gallegos M, Kraemer B, Kimble J, Wickens M. CPEB proteins control two key steps in spermatogenesis in C. elegans. Genes Dev. 2000;14:2596-609 pubmed
    ..In sum, our results demonstrate that, in C. elegans, two CPEB proteins have distinct functions in the germ line, both in spermatogenesis: FOG-1 specifies the sperm cell fate and CPB-1 executes that decision. ..
  3. Walker A, Shi Y, Blackwell T. An extensive requirement for transcription factor IID-specific TAF-1 in Caenorhabditis elegans embryonic transcription. J Biol Chem. 2004;279:15339-47 pubmed
    ..Our findings imply that in metazoans TFIID may be of widespread importance for transcription and for expression of tissue-specific genes. ..
  4. Yang M, Sun J, Sun X, Shen Q, Gao Z, Yang C. Caenorhabditis elegans protein arginine methyltransferase PRMT-5 negatively regulates DNA damage-induced apoptosis. PLoS Genet. 2009;5:e1000514 pubmed publisher
    ..These findings suggest that PRMT-5 likely represses CEP-1 transcriptional activity through CBP-1, which represents a novel regulatory mechanism of p53-dependent apoptosis. ..
  5. Chiang W, Tishkoff D, Yang B, Wilson Grady J, Yu X, Mazer T, et al. C. elegans SIRT6/7 homolog SIR-2.4 promotes DAF-16 relocalization and function during stress. PLoS Genet. 2012;8:e1002948 pubmed publisher
    ..Furthermore, they reveal a novel role for acetylation, modulated by the antagonistic activities of CBP-1 and SIR-2.4, in modulating DAF-16 localization and function. ..
  6. Wang J, Chitturi J, Ge Q, Laskova V, Wang W, Li X, et al. The C. elegans COE transcription factor UNC-3 activates lineage-specific apoptosis and affects neurite growth in the RID lineage. Development. 2015;142:1447-57 pubmed publisher
    ..Lastly, UNC-3 interacts with CBP-1, and cbp-1 mutants exhibit a similar RID phenotype to unc-3. Thus, in addition to playing a role in neuronal terminal differentiation, UNC-3 is a cell lineage-specific regulator of apoptosis. ..