cam-1

Summary

Gene Symbol: cam-1
Description: Tyrosine-protein kinase receptor cam-1
Alias: Tyrosine-protein kinase receptor cam-1
Species: Caenorhabditis elegans
Products:     cam-1

Top Publications

  1. Kim C, Forrester W. Functional analysis of the domains of the C elegans Ror receptor tyrosine kinase CAM-1. Dev Biol. 2003;264:376-90 pubmed
    ..Our results show that CAM-1 does not function exclusively as a canonical RTK and that it may function, at least in part, to regulate the distribution of a secreted ligand-possibly a Wnt protein. ..
  2. Green J, Inoue T, Sternberg P. The C. elegans ROR receptor tyrosine kinase, CAM-1, non-autonomously inhibits the Wnt pathway. Development. 2007;134:4053-62 pubmed
    ..A sequestration model is supported by our findings that the CAM-1 ECD binds to several Wnts in vitro. These results demonstrate how ROR proteins help to refine the spatial pattern of Wnt activity in a complex multicellular environment...
  3. Forrester W, Kim C, Garriga G. The Caenorhabditis elegans Ror RTK CAM-1 inhibits EGL-20/Wnt signaling in cell migration. Genetics. 2004;168:1951-62 pubmed
    ..The reversal in the migration of the left Q neuroblast and its descendants resulted from a failure to express mab-5, an egl-20 mutant phenotype. Our data suggest that CAM-1 negatively regulates EGL-20. ..
  4. Hayashi Y, Hirotsu T, Iwata R, Kage Nakadai E, Kunitomo H, Ishihara T, et al. A trophic role for Wnt-Ror kinase signaling during developmental pruning in Caenorhabditis elegans. Nat Neurosci. 2009;12:981-7 pubmed publisher
    ..These results reveal the trophic role of an atypical Wnt pathway and reinforce the classical model of developmental pruning. ..
  5. Kennerdell J, Fetter R, Bargmann C. Wnt-Ror signaling to SIA and SIB neurons directs anterior axon guidance and nerve ring placement in C. elegans. Development. 2009;136:3801-10 pubmed publisher
    ..Cell-specific rescue of cam-1 and cell ablation experiments reveal a crucial role for the SIA and SIB neurons in positioning the nerve ring, linking Wnt signaling to specific cells that organize the anterior nervous system. ..
  6. Forrester W, Dell M, Perens E, Garriga G. A C. elegans Ror receptor tyrosine kinase regulates cell motility and asymmetric cell division. Nature. 1999;400:881-5 pubmed
    ..Our results raise the possibility that Ror kinases regulate cell motility and asymmetric cell division in organisms as diverse as nematodes and mammals. ..
  7. Zinovyeva A, Yamamoto Y, Sawa H, Forrester W. Complex network of Wnt signaling regulates neuronal migrations during Caenorhabditis elegans development. Genetics. 2008;179:1357-71 pubmed publisher
    ..Finally, we find striking differences between the phenotypes of the Wnt quintuple and Frizzled quadruple mutants. ..
  8. Zhang J, Li X, Jevince A, Guan L, Wang J, Hall D, et al. Neuronal target identification requires AHA-1-mediated fine-tuning of Wnt signaling in C. elegans. PLoS Genet. 2013;9:e1003618 pubmed publisher
    ..Our study reveals a Wnt-dependent fine-tuning mechanism that is crucial for mutual target cell identification during the formation of gap junction connections. ..
  9. Chien S, Gurling M, Kim C, Craft T, FORRESTER W, Garriga G. Autonomous and nonautonomous regulation of Wnt-mediated neuronal polarity by the C. elegans Ror kinase CAM-1. Dev Biol. 2015;404:55-65 pubmed publisher
    ..In this model, loss of CAM-1 results in increased levels of Wnts that act through other Wnt receptors, masking CAM-1's autonomous role as a Wnt receptor. ..

More Information

Publications14

  1. Francis M, Evans S, Jensen M, Madsen D, Mancuso J, Norman K, et al. The Ror receptor tyrosine kinase CAM-1 is required for ACR-16-mediated synaptic transmission at the C. elegans neuromuscular junction. Neuron. 2005;46:581-94 pubmed
    ..We hypothesize that CAM-1 contributes to the localization or stabilization of postsynaptic ACR-16 receptors and presynaptic release sites. ..
  2. Song S, Zhang B, Sun H, Li X, Xiang Y, Liu Z, et al. A Wnt-Frz/Ror-Dsh pathway regulates neurite outgrowth in Caenorhabditis elegans. PLoS Genet. 2010;6: pubmed publisher
    ..Our study reveals an important role of a Wnt-Frz/Ror-Dsh pathway in regulating neurite A/P outgrowth. ..
  3. Jensen M, Hoerndli F, Brockie P, Wang R, Johnson E, Maxfield D, et al. Wnt signaling regulates acetylcholine receptor translocation and synaptic plasticity in the adult nervous system. Cell. 2012;149:173-87 pubmed publisher
    ..Using optogenetic nerve stimulation, we demonstrate activity-dependent synaptic plasticity and its dependence on ACR-16/?7 translocation mediated by Wnt signaling via LIN-17/CAM-1 heteromeric receptors. ..
  4. Moffat L, Robinson R, Bakoulis A, Clark S. The conserved transmembrane RING finger protein PLR-1 downregulates Wnt signaling by reducing Frizzled, Ror and Ryk cell-surface levels in C. elegans. Development. 2014;141:617-28 pubmed publisher
    ..We propose that PLR-1 downregulates Wnt receptor surface levels via lysine ubiquitylation of Frizzled to coordinate spatial and temporal responses to Wnts during neuronal development. ..
  5. Bainbridge T, DeAlmeida V, Izrael Tomasevic A, Chalouni C, Pan B, Goldsmith J, et al. Evolutionary divergence in the catalytic activity of the CAM-1, ROR1 and ROR2 kinase domains. PLoS ONE. 2014;9:e102695 pubmed publisher
    ..Based on these data, we conclude that human ROR1 and ROR2 are RTK-like pseudokinases. ..