Gene Symbol: bub-1
Description: Mitotic checkpoint serine/threonine-protein kinase bub-1
Alias: Mitotic checkpoint serine/threonine-protein kinase bub-1
Species: Caenorhabditis elegans
Oegema K, Desai A, Rybina S, Kirkham M, Hyman A. Functional analysis of kinetochore assembly in Caenorhabditis elegans. J Cell Biol. 2001;153:1209-26 pubmed
..Furthermore, kinetochore assembly and the recruitment of CeINCENP to chromosomes are independent. These results suggest distinct roles for the kinetochore and the chromosomal passengers in mitotic chromosome segregation. ..
Gassmann R, Essex A, Hu J, Maddox P, Motegi F, Sugimoto A, et al
. A new mechanism controlling kinetochore-microtubule interactions revealed by comparison of two dynein-targeting components: SPDL-1 and the Rod/Zwilch/Zw10 complex. Genes Dev. 2008;22:2385-99 pubmed publisher
Essex A, Dammermann A, Lewellyn L, Oegema K, Desai A. Systematic analysis in Caenorhabditis elegans reveals that the spindle checkpoint is composed of two largely independent branches. Mol Biol Cell. 2009;20:1252-67 pubmed publisher
..We discuss the rationale for a bipartite checkpoint mechanism in which a core Mad1(MDF-1)/Mad2(MDF-2) signal generated at kinetochores is integrated with a separate cytoplasmic Mad3(SAN-1)/BUB-3-based pathway. ..
Dumont J, Oegema K, Desai A. A kinetochore-independent mechanism drives anaphase chromosome separation during acentrosomal meiosis. Nat Cell Biol. 2010;12:894-901 pubmed publisher
..We suggest that separation is controlled by a meiosis-specific chromosomal domain to coordinate cohesin removal and chromosome segregation. ..
Wang X, Liu M, Li W, Suh C, Zhu Z, Jin Y, et al
. The function of a spindle checkpoint gene bub-1 in C. elegans development. PLoS ONE. 2009;4:e5912 pubmed publisher
..elegans bub-1 is required both maternally and zygotically. Further, our genetic analysis is consistent with that the function of bub-1 in C. elegans is likely similar to its yeast and mammalian homologs. ..
Kim T, Moyle M, Lara Gonzalez P, de Groot C, Oegema K, Desai A. Kinetochore-localized BUB-1/BUB-3 complex promotes anaphase onset in C. elegans. J Cell Biol. 2015;209:507-17 pubmed publisher
Espeut J, Lara Gonzalez P, Sassine M, Shiau A, Desai A, Abrieu A. Natural Loss of Mps1 Kinase in Nematodes Uncovers a Role for Polo-like Kinase 1 in Spindle Checkpoint Initiation. Cell Rep. 2015;12:58-65 pubmed publisher
..Thus, the finding that PLK-1 functionally substitutes for Mps1 in checkpoint initiation in C. elegans uncovered a role for Plk1 in species that have Mps1. ..
Cockell M, Baumer K, GONCZY P. lis-1 is required for dynein-dependent cell division processes in C. elegans embryos. J Cell Sci. 2004;117:4571-82 pubmed
..These results suggest that dynein and Lis1, albeit functioning in identical processes, are targeted partially independently of one another. ..
Moyle M, Kim T, Hattersley N, Espeut J, Cheerambathur D, Oegema K, et al
. A Bub1-Mad1 interaction targets the Mad1-Mad2 complex to unattached kinetochores to initiate the spindle checkpoint. J Cell Biol. 2014;204:647-57 pubmed publisher
..These results delineate an interaction between BUB-1 and MAD-1 that targets MAD-1-MAD-2 complexes to kinetochores and is essential for spindle checkpoint signaling. ..