bro-1

Summary

Gene Symbol: bro-1
Description: BROther (Drosophila tx factor partner) homolog
Alias: BROther (Drosophila tx factor partner) homolog
Species: Caenorhabditis elegans

Top Publications

  1. Xia D, Zhang Y, Huang X, Sun Y, Zhang H. The C. elegans CBFbeta homolog, BRO-1, regulates the proliferation, differentiation and specification of the stem cell-like seam cell lineages. Dev Biol. 2007;309:259-72 pubmed
    ..Our studies indicate that the transcriptional repression activity of the RNT-1/BRO-1 complex regulates the G1 to S cell cycle progression during seam cell division. ..
  2. Kagoshima H, Nimmo R, Saad N, Tanaka J, Miwa Y, Mitani S, et al. The C. elegans CBFbeta homologue BRO-1 interacts with the Runx factor, RNT-1, to promote stem cell proliferation and self-renewal. Development. 2007;134:3905-15 pubmed
    ..These studies provide new insights into the function and regulation of this important cancer-associated DNA-binding complex in stem cells and support the view that Runx/CBFbeta factors have oncogenic potential. ..
  3. Brabin C, Appleford P, Woollard A. The Caenorhabditis elegans GATA factor ELT-1 works through the cell proliferation regulator BRO-1 and the Fusogen EFF-1 to maintain the seam stem-like fate. PLoS Genet. 2011;7:e1002200 pubmed publisher
    ..Overall, our data suggest that ELT-1 has dual roles in the stem-like seam cells, acting both to promote proliferation and prevent differentiation. ..