Research Topics

Genomes and Genes



Gene Symbol: bir-1
Description: Chromosomal passenger complex protein bir-1
Alias: Chromosomal passenger complex protein bir-1
Species: Caenorhabditis elegans

Top Publications

  1. Speliotes E, Uren A, Vaux D, Horvitz H. The survivin-like C. elegans BIR-1 protein acts with the Aurora-like kinase AIR-2 to affect chromosomes and the spindle midzone. Mol Cell. 2000;6:211-23 pubmed
    ..elegans. Deregulation of bir-1 promotes changes in ploidy, suggesting that similar deregulation of mammalian BIRPs may contribute to tumorigenesis. ..
  2. Fraser A, James C, Evan G, Hengartner M. Caenorhabditis elegans inhibitor of apoptosis protein (IAP) homologue BIR-1 plays a conserved role in cytokinesis. Curr Biol. 1999;9:292-301 pubmed
    ..We suggest that BIRPs may regulate cytoskeletal changes in diverse biological processes including cytokinesis and apoptosis. ..
  3. Kostrouchova M, Kostrouch Z, Saudek V, Piatigorsky J, Rall J. BIR-1, a Caenorhabditis elegans homologue of Survivin, regulates transcription and development. Proc Natl Acad Sci U S A. 2003;100:5240-5 pubmed
    ..In a heterologous transfection system, BIR-1 augments thyroid hormone-regulated transcription and has an additive effect with SKIP. These results show that BIR-1 functions in the regulation of transcription and development. ..
  4. Romano A, Guse A, Krascenicova I, Schnabel H, Schnabel R, Glotzer M. CSC-1: a subunit of the Aurora B kinase complex that binds to the survivin-like protein BIR-1 and the incenp-like protein ICP-1. J Cell Biol. 2003;161:229-36 pubmed
    ..ICP-1 dramatically stimulates AIR-2 kinase activity. This activity is not stimulated by CSC-1/BIR-1, suggesting that these two subunits function as targeting subunits for AIR-2 kinase. ..
  5. LibĂ˝ P, Pohludka M, Vohanka J, Kostrouch D, Kostrouchova M, Rall J, et al. BIR-1, the homologue of human Survivin, regulates expression of developmentally active collagen genes in C. elegans. Folia Biol (Praha). 2006;52:101-8 pubmed
    ..elegans and has a strong ability to affect transcription of developmentally active genes if overexpressed. ..