bec 1

Summary

Gene Symbol: bec 1
Description: Beclin homolog
Alias: Beclin homolog
Species: Caenorhabditis elegans

Top Publications

  1. Melendez A, Talloczy Z, Seaman M, Eskelinen E, Hall D, Levine B. Autophagy genes are essential for dauer development and life-span extension in C. elegans. Science. 2003;301:1387-91 pubmed
    ..elegans orthologs of the yeast autophagy genes APG1, APG7, APG8, and AUT10. Thus, autophagy is a cellular pathway essential for dauer development and life-span extension in C. elegans. ..
  2. Takacs Vellai K, Vellai T, Puoti A, Passannante M, Wicky C, Streit A, et al. Inactivation of the autophagy gene bec-1 triggers apoptotic cell death in C. elegans. Curr Biol. 2005;15:1513-7 pubmed
    ..Based on our results, we propose that bec-1 represents a link between autophagy and apoptosis, thus supporting the view that the two processes act in concerted manner in the cell death machinery. ..
  3. Lapierre L, Gelino S, Melendez A, Hansen M. Autophagy and lipid metabolism coordinately modulate life span in germline-less C. elegans. Curr Biol. 2011;21:1507-14 pubmed publisher
    ..Collectively, our data offer a novel mechanism by which autophagy and the lipase LIPL-4 interdependently modulate aging in germline-deficient C. elegans by maintaining lipid homeostasis to prolong life span. ..
  4. Lapierre L, Silvestrini M, Núñez L, Ames K, Wong S, Le T, et al. Autophagy genes are required for normal lipid levels in C. elegans. Autophagy. 2013;9:278-86 pubmed publisher
    ..Taken together, these observations suggest a broader role for autophagy in lipid remodeling in C. elegans. ..
  5. Jia K, Levine B. Autophagy is required for dietary restriction-mediated life span extension in C. elegans. Autophagy. 2007;3:597-9 pubmed
    ..elegans life span. Since autophagy and longevity control are highly conserved from C. elegans to mammals, a similar role for autophagy in dietary restriction-mediated life span extension may also exist in mammals. ..
  6. Jia K, Hart A, Levine B. Autophagy genes protect against disease caused by polyglutamine expansion proteins in Caenorhabditis elegans. Autophagy. 2007;3:21-5 pubmed
    ..These data provide in vivo genetic evidence that autophagy genes suppress the accumulation of polyQ aggregates and protect cells from disease caused by polyQ toxicity. ..
  7. Schipanski A, Lange S, Segref A, Gutschmidt A, Lomas D, Miranda E, et al. A novel interaction between aging and ER overload in a protein conformational dementia. Genetics. 2013;193:865-76 pubmed publisher
    ..These data suggest that targets aimed at increasing UPR capacity in neurons are valuable tools for therapeutic intervention. ..
  8. Jia K, Thomas C, Akbar M, Sun Q, Adams Huet B, Gilpin C, et al. Autophagy genes protect against Salmonella typhimurium infection and mediate insulin signaling-regulated pathogen resistance. Proc Natl Acad Sci U S A. 2009;106:14564-9 pubmed publisher
    ..Thus, autophagy genes play an essential role in host defense in vivo against an intracellular bacterial pathogen and mediate pathogen resistance in long-lived mutant nematodes. ..
  9. Zhang J, Jia K. A protocol to infect Caenorhabditis elegans with Salmonella typhimurium. J Vis Exp. 2014;:e51703 pubmed publisher
    ..Since C. elegans whole genome RNAi libraries are available, this protocol makes it possible to comprehensively screen for C. elegans genes that protect against Salmonella and other intestinal pathogens using genome-wide RNAi libraries. ..

More Information

Publications22

  1. Hars E, Qi H, Ryazanov A, Jin S, Cai L, Hu C, et al. Autophagy regulates ageing in C. elegans. Autophagy. 2007;3:93-5 pubmed
    ..elegans using RNAi. We showed that RNAi shortened the lifespan of both wild type and daf-2 mutant C. elegans, providing strong support for a role of autophagy in ageing regulation. ..
  2. Miedel M, Graf N, Stephen K, Long O, Pak S, Perlmutter D, et al. A pro-cathepsin L mutant is a luminal substrate for endoplasmic-reticulum-associated degradation in C. elegans. PLoS ONE. 2012;7:e40145 pubmed publisher
    ..elegans. This transgenic line will facilitate high-throughput genetic or pharmacological screens for ERAD modifiers using widefield epifluorescence microscopy. ..
  3. Schiavi A, Torgovnick A, Kell A, Megalou E, Castelein N, Guccini I, et al. Autophagy induction extends lifespan and reduces lipid content in response to frataxin silencing in C. elegans. Exp Gerontol. 2013;48:191-201 pubmed publisher
  4. O Rourke E, Kuballa P, Xavier R, Ruvkun G. ?-6 Polyunsaturated fatty acids extend life span through the activation of autophagy. Genes Dev. 2013;27:429-40 pubmed publisher
    ..We propose that the salubrious effects of dietary supplementation with ?-3/6 PUFAs (fish oils) that have emerged from epidemiological studies in humans may be due to a similar activation of autophagic programs. ..
  5. Samara C, Syntichaki P, Tavernarakis N. Autophagy is required for necrotic cell death in Caenorhabditis elegans. Cell Death Differ. 2008;15:105-12 pubmed
    ..Our findings demonstrate that autophagy contributes to cellular destruction during necrosis. Thus, interfering with the autophagic process may protect neurons against necrotic damage in humans. ..
  6. Kang C, You Y, Avery L. Dual roles of autophagy in the survival of Caenorhabditis elegans during starvation. Genes Dev. 2007;21:2161-71 pubmed
    ..Taken together, our results demonstrate that autophagy can have either prosurvival or prodeath functions in an organism, depending on its level of activation. ..
  7. Tóth M, Simon P, Kovacs A, Vellai T. Influence of autophagy genes on ion-channel-dependent neuronal degeneration in Caenorhabditis elegans. J Cell Sci. 2007;120:1134-41 pubmed
    ..Our findings reveal a role for autophagy genes in neuronal cell loss in C. elegans. ..
  8. Liu K, Jian Y, Sun X, Yang C, Gao Z, Zhang Z, et al. Negative regulation of phosphatidylinositol 3-phosphate levels in early-to-late endosome conversion. J Cell Biol. 2016;212:181-98 pubmed publisher
    ..WDR91 and WDR81 interact with Beclin1 and inhibit PI3K complex activity. These findings reveal a conserved mechanism that controls appropriate PtdIns3P levels in early-to-late endosome conversion. ..
  9. Niso Santano M, Malik S, Pietrocola F, Bravo San Pedro J, Mariño G, Cianfanelli V, et al. Unsaturated fatty acids induce non-canonical autophagy. EMBO J. 2015;34:1025-41 pubmed publisher
    ..Thus, unsaturated fatty acids induce a non-canonical, phylogenetically conserved, autophagic response that in mammalian cells relies on the Golgi apparatus. ..
  10. Hoffman S, Martin D, Melendez A, Bargonetti J. C. elegans CEP-1/p53 and BEC-1 are involved in DNA repair. PLoS ONE. 2014;9:e88828 pubmed publisher
    ..These results strongly support cross-talk between BEC-1 and CEP-1 to protect the C. elegans genome. ..
  11. Ruck A, Attonito J, Garces K, Núñez L, Palmisano N, Rubel Z, et al. The Atg6/Vps30/Beclin 1 ortholog BEC-1 mediates endocytic retrograde transport in addition to autophagy in C. elegans. Autophagy. 2011;7:386-400 pubmed
    ..In addition, autophagy genes may also be required for cell corpse clearance, as we find that RNAi against atg-18 or unc-51 also results in a lack of cell corpse clearance. ..
  12. Yang P, Zhang H. The coiled-coil domain protein EPG-8 plays an essential role in the autophagy pathway in C. elegans. Autophagy. 2011;7:159-65 pubmed
    ..EPG-8 directly interacts with the C. elegans Beclin 1 homolog, BEC-1. Our study demonstrates that epg-8 may function as a highly divergent homolog of the yeast autophagy gene Atg14. ..
  13. Aladzsity I, Tóth M, Sigmond T, Szabo E, Bicsák B, Barna J, et al. Autophagy genes unc-51 and bec-1 are required for normal cell size in Caenorhabditis elegans. Genetics. 2007;177:655-60 pubmed
    ..This function for unc-51 and bec-1 in cell size control and their interaction with these two growth modulatory pathways may represent a link between the hormonal and nutritional regulation of cell growth. ..