bbs-8

Summary

Gene Symbol: bbs-8
Description: Tetratricopeptide repeat protein 8
Alias: Tetratricopeptide repeat protein 8
Species: Caenorhabditis elegans

Top Publications

  1. Ansley S, Badano J, Blacque O, Hill J, Hoskins B, Leitch C, et al. Basal body dysfunction is a likely cause of pleiotropic Bardet-Biedl syndrome. Nature. 2003;425:628-33 pubmed
  2. Blacque O, Reardon M, Li C, McCarthy J, Mahjoub M, Ansley S, et al. Loss of C. elegans BBS-7 and BBS-8 protein function results in cilia defects and compromised intraflagellar transport. Genes Dev. 2004;18:1630-42 pubmed
    ..Our findings also suggest that some of the cardinal and secondary symptoms of BBS, such as obesity, diabetes, cardiomyopathy, and learning defects may result from cilia dysfunction. ..
  3. Torayama I, Ishihara T, Katsura I. Caenorhabditis elegans integrates the signals of butanone and food to enhance chemotaxis to butanone. J Neurosci. 2007;27:741-50 pubmed
  4. Nguyen P, Liou W, Hall D, Leroux M. Ciliopathy proteins establish a bipartite signaling compartment in a C. elegans thermosensory neuron. J Cell Sci. 2014;127:5317-30 pubmed publisher
    ..We propose that differential compartmentalization of signal transduction components by ciliary proteins is important for the functions of ciliated sensory neurons. ..
  5. Jensen V, Carter S, Sanders A, Li C, Kennedy J, Timbers T, et al. Whole-Organism Developmental Expression Profiling Identifies RAB-28 as a Novel Ciliary GTPase Associated with the BBSome and Intraflagellar Transport. PLoS Genet. 2016;12:e1006469 pubmed publisher