Gene Symbol: atn-1
Species: Caenorhabditis elegans
Etheridge T, Oczypok E, Lehmann S, Fields B, Shephard F, Jacobson L, et al
. Calpains mediate integrin attachment complex maintenance of adult muscle in Caenorhabditis elegans. PLoS Genet. 2012;8:e1002471 pubmed publisher
..Since C. elegans lacks satellite cells, this mechanism is intrinsic to the muscles and raises the question if such a mechanism also exists in higher metazoans. ..
Sarov M, Murray J, Schanze K, Pozniakovski A, Niu W, Angermann K, et al
. A genome-scale resource for in vivo tag-based protein function exploration in C. elegans. Cell. 2012;150:855-66 pubmed publisher
..We illustrate the utility of the resource by systematic chromatin immunopurification and automated 4D imaging, which produced detailed DNA binding and cell/tissue distribution maps for key transcription factor proteins. ..
Lecroisey C, Brouilly N, Qadota H, Mariol M, Rochette N, Martin E, et al
. ZYX-1, the unique zyxin protein of Caenorhabditis elegans, is involved in dystrophin-dependent muscle degeneration. Mol Biol Cell. 2013;24:1232-49 pubmed publisher
..assays ZYX-1 interacts with several known dense body and M-line proteins, including DEB-1 (vinculin) and ATN-1 (?-actinin)...
Francis G, Waterston R. Muscle organization in Caenorhabditis elegans: localization of proteins implicated in thin filament attachment and I-band organization. J Cell Biol. 1985;101:1532-49 pubmed
..A major constituent of the dense-body is a 107,000-D polypeptide that shares determinants with vertebrate alpha-actinin. A second dense-body constituent is a more basic and antigenically distinct 107,000-D polypeptide that is ..
Yamashiro S, Cox E, Baillie D, Hardin J, Ono S. Sarcomeric actin organization is synergistically promoted by tropomodulin, ADF/cofilin, AIP1 and profilin in C. elegans. J Cell Sci. 2008;121:3867-77 pubmed publisher
..Thus, we propose a model in which tropomodulin and enhancers of actin dynamics synergistically regulate elongation and shortening of actin filaments at the pointed end. ..
Warner A, Xiong G, Qadota H, Rogalski T, Vogl A, Moerman D, et al
. CPNA-1, a copine domain protein, is located at integrin adhesion sites and is required for myofilament stability in Caenorhabditis elegans. Mol Biol Cell. 2013;24:601-16 pubmed publisher
..We propose that CPNA-1 acts as a linker between an integrin-associated protein, PAT-6, and membrane-distal components of integrin adhesion complexes in the muscle of C. elegans. ..
Winkelman J, Suarez C, Hocky G, Harker A, Morganthaler A, Christensen J, et al
. Fascin- and ?-Actinin-Bundled Networks Contain Intrinsic Structural Features that Drive Protein Sorting. Curr Biol. 2016;26:2697-2706 pubmed publisher
..fluorescence microscopy, we discovered that sorting of the prominent actin-bundling proteins fascin and ?-actinin to distinct networks is an intrinsic behavior, free of complicated cellular signaling cascades...