Gene Symbol: atg-7
Description: AuTophaGy (yeast Atg homolog)
Alias: AuTophaGy (yeast Atg homolog)
Species: Caenorhabditis elegans
Melendez A, Talloczy Z, Seaman M, Eskelinen E, Hall D, Levine B. Autophagy genes are essential for dauer development and life-span extension in C. elegans. Science. 2003;301:1387-91 pubmed
..elegans orthologs of the yeast autophagy genes APG1, APG7, APG8, and AUT10. Thus, autophagy is a cellular pathway essential for dauer development and life-span extension in C. elegans. ..
Jia K, Hart A, Levine B. Autophagy genes protect against disease caused by polyglutamine expansion proteins in Caenorhabditis elegans. Autophagy. 2007;3:21-5 pubmed
..These data provide in vivo genetic evidence that autophagy genes suppress the accumulation of polyQ aggregates and protect cells from disease caused by polyQ toxicity. ..
Hars E, Qi H, Ryazanov A, Jin S, Cai L, Hu C, et al
. Autophagy regulates ageing in C. elegans. Autophagy. 2007;3:93-5 pubmed
..elegans using RNAi. We showed that RNAi shortened the lifespan of both wild type and daf-2 mutant C. elegans, providing strong support for a role of autophagy in ageing regulation. ..
Samara C, Syntichaki P, Tavernarakis N. Autophagy is required for necrotic cell death in Caenorhabditis elegans. Cell Death Differ. 2008;15:105-12 pubmed
..Our findings demonstrate that autophagy contributes to cellular destruction during necrosis. Thus, interfering with the autophagic process may protect neurons against necrotic damage in humans. ..
Jia K, Levine B. Autophagy is required for dietary restriction-mediated life span extension in C. elegans. Autophagy. 2007;3:597-9 pubmed
..elegans life span. Since autophagy and longevity control are highly conserved from C. elegans to mammals, a similar role for autophagy in dietary restriction-mediated life span extension may also exist in mammals. ..
Manil Ségalen M, Lefebvre C, Jenzer C, Trichet M, Boulogne C, Satiat Jeunemaitre B, et al
. The C. elegans LC3 acts downstream of GABARAP to degrade autophagosomes by interacting with the HOPS subunit VPS39. Dev Cell. 2014;28:43-55 pubmed publisher
..The duplications of Atg8 in metazoans thus allowed the acquisition of specialized functions for autophagosome maturation. ..
Erdélyi P, Borsos E, Takacs Vellai K, Kovacs T, Kovacs A, Sigmond T, et al
. Shared developmental roles and transcriptional control of autophagy and apoptosis in Caenorhabditis elegans. J Cell Sci. 2011;124:1510-8 pubmed publisher
..The identification of apoptosis and autophagy as compensatory cellular pathways in C. elegans might help us to understand how dysregulated PCD in humans can lead to diverse pathologies, including cancer, neurodegeneration and diabetes. ..
Al Rawi S, Louvet Vallee S, Djeddi A, Sachse M, Culetto E, Hajjar C, et al
. Postfertilization autophagy of sperm organelles prevents paternal mitochondrial DNA transmission. Science. 2011;334:1144-7 pubmed publisher