Gene Symbol: atfs-1
Description: Stress activated transcription factor atfs-1
Alias: Stress activated transcription factor atfs-1
Species: Caenorhabditis elegans

Top Publications

  1. Haynes C, Yang Y, Blais S, Neubert T, Ron D. The matrix peptide exporter HAF-1 signals a mitochondrial UPR by activating the transcription factor ZC376.7 in C. elegans. Mol Cell. 2010;37:529-40 pubmed publisher
  2. Rauthan M, Ranji P, Aguilera Pradenas N, Pitot C, Pilon M. The mitochondrial unfolded protein response activator ATFS-1 protects cells from inhibition of the mevalonate pathway. Proc Natl Acad Sci U S A. 2013;110:5981-6 pubmed publisher
  3. Pellegrino M, Nargund A, Kirienko N, Gillis R, Fiorese C, Haynes C. Mitochondrial UPR-regulated innate immunity provides resistance to pathogen infection. Nature. 2014;516:414-7 pubmed publisher
    ..We propose that ATFS-1 import efficiency and the UPR(mt) is a means to detect pathogens that target mitochondria and initiate a protective innate immune response. ..
  4. Nargund A, Fiorese C, Pellegrino M, Deng P, Haynes C. Mitochondrial and nuclear accumulation of the transcription factor ATFS-1 promotes OXPHOS recovery during the UPR(mt). Mol Cell. 2015;58:123-33 pubmed publisher
  5. Nargund A, Pellegrino M, Fiorese C, Baker B, Haynes C. Mitochondrial import efficiency of ATFS-1 regulates mitochondrial UPR activation. Science. 2012;337:587-90 pubmed publisher
    ..Our results show that cells monitor mitochondrial import efficiency via ATFS-1 to coordinate the level of mitochondrial dysfunction with the protective transcriptional response. ..
  6. Guo B, Huang X, Zhang P, Qi L, Liang Q, Zhang X, et al. Genome-wide screen identifies signaling pathways that regulate autophagy during Caenorhabditis elegans development. EMBO Rep. 2014;15:705-13 pubmed publisher
    ..Our study thus provides a framework for understanding the role of signaling pathways in regulating autophagy under physiological conditions. ..
  7. Baker B, Nargund A, Sun T, Haynes C. Protective coupling of mitochondrial function and protein synthesis via the eIF2? kinase GCN-2. PLoS Genet. 2012;8:e1002760 pubmed publisher
    ..These findings are consistent with translational control and stress-dependent chaperone induction acting in complementary arms of the UPR(mt)...