asp-3

Summary

Gene Symbol: asp-3
Description: Aspartic protease 3
Alias: Aspartic protease 3
Species: Caenorhabditis elegans

Top Publications

  1. Syntichaki P, Xu K, Driscoll M, Tavernarakis N. Specific aspartyl and calpain proteases are required for neurodegeneration in C. elegans. Nature. 2002;419:939-44 pubmed
    ..Similar proteases may mediate necrotic cell death in humans. ..
  2. Evans E, Kawli T, Tan M. Pseudomonas aeruginosa suppresses host immunity by activating the DAF-2 insulin-like signaling pathway in Caenorhabditis elegans. PLoS Pathog. 2008;4:e1000175 pubmed publisher
    ..Our results reveal a new mechanism by which P. aeruginosa suppresses host immune defense. ..
  3. Yuan Y, Kadiyala C, Ching T, Hakimi P, Saha S, Xu H, et al. Enhanced energy metabolism contributes to the extended life span of calorie-restricted Caenorhabditis elegans. J Biol Chem. 2012;287:31414-26 pubmed publisher
    ..We conclude that an increase, not a decrease in fuel consumption, via an accelerated oxidation of fuels in the TCA cycle is involved in life span regulation; this mechanism may be conserved across phylogeny. ..