Gene Symbol: ash-2
Description: ASH histone methyltransferase complex subunit (Drosophila absent, small or homeotic discs);Set1/Ash2 histone methyltransferase complex subunit ash-2
Alias: ASH histone methyltransferase complex subunit (Drosophila absent, small or homeotic discs);Set1/Ash2 histone methyltransferase complex subunit ash-2
Species: Caenorhabditis elegans
Greer E, Maures T, Hauswirth A, Green E, Leeman D, Maro G, et al
. Members of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegans. Nature. 2010;466:383-7 pubmed publisher
..These results indicate that the longevity of the soma is regulated by an H3K4 methyltransferase/demethylase complex acting in the C. elegans germline. ..
Fisher K, Southall S, Wilson J, Poulin G. Methylation and demethylation activities of a C. elegans MLL-like complex attenuate RAS signalling. Dev Biol. 2010;341:142-53 pubmed publisher
..Therefore, the C. elegans MLL-like complex cooperates with the NuA4/TIP60 complex to regulate the expression of a novel effector, AJM-1. ..
Xiao Y, Bedet C, Robert V, Simonet T, Dunkelbarger S, Rakotomalala C, et al
. Caenorhabditis elegans chromatin-associated proteins SET-2 and ASH-2 are differentially required for histone H3 Lys 4 methylation in embryos and adult germ cells. Proc Natl Acad Sci U S A. 2011;108:8305-10 pubmed publisher
..This study demonstrates that individual subunits of SET1-related complexes can show tissue specificity and developmental regulation and establishes C. elegans as a model to study SET1-related complexes in a multicellular organism. ..
Wang S, Fisher K, Poulin G. Lineage specific trimethylation of H3 on lysine 4 during C. elegans early embryogenesis. Dev Biol. 2011;355:227-38 pubmed publisher
..In contrast, the deposition of H3K4me2 and H3K27me2/3 is not lineage restricted. Taken together, our data reveal that H3K4me3 deposition is highly regulated according to the cell lineage involved. ..
Vandamme J, Lettier G, Sidoli S, Di Schiavi E, N rregaard Jensen O, Salcini A. The C. elegans H3K27 demethylase UTX-1 is essential for normal development, independent of its enzymatic activity. PLoS Genet. 2012;8:e1002647 pubmed publisher
..Taken together, these results demonstrate that UTX-1 is required for many aspects of nematode development; but, unexpectedly, this function is independent of its enzymatic activity...
Zuryn S, Ahier A, Portoso M, White E, Morin M, Margueron R, et al
. Transdifferentiation. Sequential histone-modifying activities determine the robustness of transdifferentiation. Science. 2014;345:826-9 pubmed publisher
..Our results draw parallels between epigenetic mechanisms underlying robust Td in nature and efficient cell reprogramming in vitro. ..
Yu Y, Zhi L, Guan X, Wang D, Wang D. FLP-4 neuropeptide and its receptor in a neuronal circuit regulate preference choice through functions of ASH-2 trithorax complex in Caenorhabditis elegans. Sci Rep. 2016;6:21485 pubmed publisher
..The identified novel neuronal circuit and the underlying molecular mechanisms will strengthen our understanding neuronal basis of preference choice in animals. ..
Greer E, Maures T, Ucar D, Hauswirth A, Mancini E, Lim J, et al
. Transgenerational epigenetic inheritance of longevity in Caenorhabditis elegans. Nature. 2011;479:365-71 pubmed publisher
..Thus, manipulation of specific chromatin modifiers only in parents can induce an epigenetic memory of longevity in descendants. ..