Gene Symbol: arx-2
Description: Actin-related protein 2
Alias: Actin-related protein 2
Species: Caenorhabditis elegans

Top Publications

  1. Severson A, Baillie D, Bowerman B. A Formin Homology protein and a profilin are required for cytokinesis and Arp2/3-independent assembly of cortical microfilaments in C. elegans. Curr Biol. 2002;12:2066-75 pubmed
    ..These data suggest that CYK-1 and PFN-1 may nucleate MFs, as has recently been shown for an FH protein and a profilin in yeast. ..
  2. Roh Johnson M, Goldstein B. In vivo roles for Arp2/3 in cortical actin organization during C. elegans gastrulation. J Cell Sci. 2009;122:3983-93 pubmed publisher
    ..elegans gastrulation: in addition to apical constriction, internalization of the endoderm might involve dynamic Arp2/3-dependent F-actin-rich extensions on one side of a ring of cells. ..
  3. Patel F, Bernadskaya Y, Chen E, Jobanputra A, Pooladi Z, Freeman K, et al. The WAVE/SCAR complex promotes polarized cell movements and actin enrichment in epithelia during C. elegans embryogenesis. Dev Biol. 2008;324:297-309 pubmed publisher
    ..We propose that temporally and spatially regulated actin nucleation by the Rac-WAVE/SCAR-Arp2/3 pathway is required for epithelial cell organization and movements during morphogenesis. ..
  4. Sawyer J, Glass S, Li T, Shemer G, White N, Starostina N, et al. Overcoming redundancy: an RNAi enhancer screen for morphogenesis genes in Caenorhabditis elegans. Genetics. 2011;188:549-64 pubmed publisher
    ..Our results implicate new genes in C. elegans gastrulation, and they show that an RNAi-based enhancer screen in C. elegans can be used as an efficient means to identify important but redundant or partially redundant developmental genes. ..
  5. Sawa M, Suetsugu S, Sugimoto A, Miki H, Yamamoto M, Takenawa T. Essential role of the C. elegans Arp2/3 complex in cell migration during ventral enclosure. J Cell Sci. 2003;116:1505-18 pubmed
    ..The stable localization of WSP-1 was dependent on the presence of Arp2/3 complex, suggesting an interaction between the Arp2/3 complex and WSP-1 in vivo. ..