arl-13

Summary

Gene Symbol: arl-13
Description: ADP-ribosylation factor-like protein 13B;ARF-Like
Alias: ADP-ribosylation factor-like protein 13B;ARF-Like
Species: Caenorhabditis elegans

Top Publications

  1. Cevik S, Hori Y, Kaplan O, Kida K, Toivenon T, Foley Fisher C, et al. Joubert syndrome Arl13b functions at ciliary membranes and stabilizes protein transport in Caenorhabditis elegans. J Cell Biol. 2010;188:953-69 pubmed publisher
    ..Together, these data implicate a role for JS-associated Arl13b at ciliary membranes, where it regulates ciliary transmembrane protein localizations and anterograde IFT assembly stability. ..
  2. Li Y, Zhang Q, Wei Q, Zhang Y, Ling K, Hu J. SUMOylation of the small GTPase ARL-13 promotes ciliary targeting of sensory receptors. J Cell Biol. 2012;199:589-98 pubmed publisher
    ..Our data reveal a novel but conserved role for the SUMOylation modification of ciliary small GTPase ARL13B in specifically regulating the proper ciliary targeting of various sensory receptors. ..
  3. Li Y, Wei Q, Zhang Y, Ling K, Hu J. The small GTPases ARL-13 and ARL-3 coordinate intraflagellar transport and ciliogenesis. J Cell Biol. 2010;189:1039-51 pubmed publisher
    ..Thus, we propose that two conserved small GTPases, ARL-13 and ARL-3, coordinate to regulate IFT and that perturbing this balance results in cilia deformation. ..
  4. Cevik S, Sanders A, Van Wijk E, Boldt K, Clarke L, van Reeuwijk J, et al. Active transport and diffusion barriers restrict Joubert Syndrome-associated ARL13B/ARL-13 to an Inv-like ciliary membrane subdomain. PLoS Genet. 2013;9:e1003977 pubmed publisher
    ..We conclude that MKS/NPHP modules comprise a TZ barrier to ARL-13 diffusion, whereas IFT genes predominantly facilitate ARL-13 ciliary entry and/or retention via active transport mechanisms. ..
  5. Brear A, Yoon J, Wojtyniak M, Sengupta P. Diverse cell type-specific mechanisms localize G protein-coupled receptors to Caenorhabditis elegans sensory cilia. Genetics. 2014;197:667-84 pubmed publisher
  6. Nguyen P, Liou W, Hall D, Leroux M. Ciliopathy proteins establish a bipartite signaling compartment in a C. elegans thermosensory neuron. J Cell Sci. 2014;127:5317-30 pubmed publisher
    ..We propose that differential compartmentalization of signal transduction components by ciliary proteins is important for the functions of ciliated sensory neurons. ..
  7. Zhang Q, Li Y, Zhang Y, Torres V, Harris P, Ling K, et al. GTP-binding of ARL-3 is activated by ARL-13 as a GEF and stabilized by UNC-119. Sci Rep. 2016;6:24534 pubmed publisher
  8. Jensen V, Carter S, Sanders A, Li C, Kennedy J, Timbers T, et al. Whole-Organism Developmental Expression Profiling Identifies RAB-28 as a Novel Ciliary GTPase Associated with the BBSome and Intraflagellar Transport. PLoS Genet. 2016;12:e1006469 pubmed publisher
  9. Warburton Pitt S, Silva M, Nguyen K, Hall D, Barr M. The nphp-2 and arl-13 genetic modules interact to regulate ciliogenesis and ciliary microtubule patterning in C. elegans. PLoS Genet. 2014;10:e1004866 pubmed publisher
    ..We conclude that the C. elegans InvC is distinct from the doublet region, and that components in these two regions interact to regulate ciliogenesis via cilia placement, ciliary microtubule ultrastructure, and protein localization. ..