Gene Symbol: arf-3
Description: ADP-Ribosylation Factor related
Alias: ADP-Ribosylation Factor related
Species: Caenorhabditis elegans
Singhvi A, Teulière J, Talavera K, Cordes S, Ou G, Vale R, et al
. The Arf GAP CNT-2 regulates the apoptotic fate in C. elegans asymmetric neuroblast divisions. Curr Biol. 2011;21:948-54 pubmed publisher
..We provide evidence that CNT-2 regulates receptor-mediated endocytosis and consider the implications of its role in asymmetric cell divisions. ..
Dang H, Li Z, Skolnik E, Fares H. Disease-related myotubularins function in endocytic traffic in Caenorhabditis elegans. Mol Biol Cell. 2004;15:189-96 pubmed
..We demonstrate that MTM-6 and MTM-9 function as part of a complex to regulate an endocytic pathway that involves the Arf6 GTPase, and we define protein domains required for MTM-6 activity. ..
Li Y, Kelly W, Logsdon J, Schurko A, Harfe B, Hill Harfe K, et al
. Functional genomic analysis of the ADP-ribosylation factor family of GTPases: phylogeny among diverse eukaryotes and function in C. elegans. FASEB J. 2004;18:1834-50 pubmed
..elegans, at least three are required for embryogenesis. These data represent the first analysis of the role(s) of multiple members of this family in the development of a multicellular organism. ..
Parry D, Xu J, Ruvkun G. A whole-genome RNAi Screen for C. elegans miRNA pathway genes. Curr Biol. 2007;17:2013-22 pubmed
Winter J, HÃ¶pfner S, Korn K, Farnung B, Bradshaw C, Marsico G, et al
. Caenorhabditis elegans screen reveals role of PAR-5 in RAB-11-recycling endosome positioning and apicobasal cell polarity. Nat Cell Biol. 2012;14:666-76 pubmed publisher
..Our data suggest that PAR-5 acts as a regulatory hub for a polarity-maintaining network required for apicobasal asymmetry of F-actin and proper Rab11-RE positioning. ..
Neumann B, Hilliard M. Loss of MEC-17 leads to microtubule instability and axonal degeneration. Cell Rep. 2014;6:93-103 pubmed publisher
..This study therefore identifies a critical role for the conserved microtubule-associated protein MEC-17 in preserving axon integrity and preventing axonal degeneration. ..
Skorobogata O, Escobar Restrepo J, Rocheleau C. An AGEF-1/Arf GTPase/AP-1 ensemble antagonizes LET-23 EGFR basolateral localization and signaling during C. elegans vulva induction. PLoS Genet. 2014;10:e1004728 pubmed publisher
..Thus, an AGEF-1/Arf GTPase/AP-1 ensemble functions opposite the LIN-2/7/10 complex to antagonize LET-23 EGFR basolateral membrane localization and signaling. ..