Gene Symbol: aqp-1
Description: AQuaPorin or aquaglyceroporin related
Alias: AQuaPorin or aquaglyceroporin related
Species: Caenorhabditis elegans

Top Publications

  1. Huang C, Lamitina T, Agre P, Strange K. Functional analysis of the aquaporin gene family in Caenorhabditis elegans. Am J Physiol Cell Physiol. 2007;292:C1867-73 pubmed
    ..These results suggest that C. elegans aquaporins are not essential for whole animal osmoregulation and/or that deletion of aquaporin genes activates mechanisms that compensate for loss of water channel function. ..
  2. Anyanful A, Easley K, Benian G, Kalman D. Conditioning protects C. elegans from lethal effects of enteropathogenic E. coli by activating genes that regulate lifespan and innate immunity. Cell Host Microbe. 2009;5:450-62 pubmed publisher
    ..Our findings suggest that the molecular pathways that control innate immunity and lifespan may be regulated or "conditioned" by exposure to pathogens to allow survival in noxious environments. ..
  3. Singh V, Aballay A. Regulation of DAF-16-mediated Innate Immunity in Caenorhabditis elegans. J Biol Chem. 2009;284:35580-7 pubmed publisher
    ..These studies reveal a stress-inducible mechanism involved in the regulation of DAF-16 and indicate that uncontrolled DAF-16 activity and water homeostasis are a cause of the deleterious effects of excessive immune responses. ..
  4. Lee S, Murphy C, Kenyon C. Glucose shortens the life span of C. elegans by downregulating DAF-16/FOXO activity and aquaporin gene expression. Cell Metab. 2009;10:379-91 pubmed publisher
    ..Together, these findings raise the possibility that a low-sugar diet might have beneficial effects on life span in higher organisms. ..