apr-1

Summary

Gene Symbol: apr-1
Description: APC Related;Adenomatous polyposis coli protein-related protein 1
Alias: APC Related;Adenomatous polyposis coli protein-related protein 1
Species: Caenorhabditis elegans

Top Publications

  1. Rocheleau C, Downs W, Lin R, Wittmann C, Bei Y, Cha Y, et al. Wnt signaling and an APC-related gene specify endoderm in early C. elegans embryos. Cell. 1997;90:707-16 pubmed
    ..We present evidence that there may be partially redundant inputs into endoderm specification and that a subset of these genes appear also to function in determining cytoskeletal polarity in certain early blastomeres. ..
  2. Bei Y, Hogan J, Berkowitz L, Soto M, Rocheleau C, Pang K, et al. SRC-1 and Wnt signaling act together to specify endoderm and to control cleavage orientation in early C. elegans embryos. Dev Cell. 2002;3:113-25 pubmed
    ..Our findings suggest that Wnt and Src signaling function in parallel to control developmental outcomes within a single responding cell. ..
  3. Walston T, Tuskey C, Edgar L, Hawkins N, Ellis G, Bowerman B, et al. Multiple Wnt signaling pathways converge to orient the mitotic spindle in early C. elegans embryos. Dev Cell. 2004;7:831-41 pubmed
  4. Putzke A, Rothman J. Repression of Wnt signaling by a Fer-type nonreceptor tyrosine kinase. Proc Natl Acad Sci U S A. 2010;107:16154-9 pubmed publisher
    ..These findings highlight a role for a Fer-type kinase in setting the proper levels of Wnt signaling and demonstrate the importance of this modulation in ensuring appropriate cell division. ..
  5. Rocheleau C, Yasuda J, Shin T, Lin R, Sawa H, Okano H, et al. WRM-1 activates the LIT-1 protein kinase to transduce anterior/posterior polarity signals in C. elegans. Cell. 1999;97:717-26 pubmed
    ..This activation leads to phosphorylation of POP-1 and to apparent changes in its subcellular localization. Our findings provide evidence for novel regulatory avenues for an evolutionarily conserved Wnt/WG signaling pathway. ..
  6. Shin T, Yasuda J, Rocheleau C, Lin R, Soto M, Bei Y, et al. MOM-4, a MAP kinase kinase kinase-related protein, activates WRM-1/LIT-1 kinase to transduce anterior/posterior polarity signals in C. elegans. Mol Cell. 1999;4:275-80 pubmed
    ..These findings suggest that anterior/posterior polarity signaling in C. elegans may involve a MAP kinase-like signaling mechanism. ..
  7. Korswagen H, Coudreuse D, Betist M, van de Water S, Zivkovic D, Clevers H. The Axin-like protein PRY-1 is a negative regulator of a canonical Wnt pathway in C. elegans. Genes Dev. 2002;16:1291-302 pubmed
    ..We conclude that a highly divergent destruction complex consisting of PRY-1, SGG-1, and APR-1 regulates BAR-1/beta-catenin signaling in C. elegans. ..
  8. Baldwin A, Phillips B. The tumor suppressor APC differentially regulates multiple ?-catenins through the function of axin and CKI? during C. elegans asymmetric stem cell divisions. J Cell Sci. 2014;127:2771-81 pubmed publisher
    ..We propose a model whereby Wnt signaling, through CKI?, regulates the function of two distinct pools of APC - one APC pool negatively regulates SYS-1, whereas the second pool stabilizes microtubules and promotes WRM-1 nuclear export. ..
  9. Hoier E, Mohler W, Kim S, Hajnal A. The Caenorhabditis elegans APC-related gene apr-1 is required for epithelial cell migration and Hox gene expression. Genes Dev. 2000;14:874-86 pubmed
    ..Thus, APR-1 may positively regulate the activity of the beta-Catenin/Armadillo-related proteins HMP-2 in migrating epithelial cells and BAR-1 in the vulval precursor cells...

More Information

Publications15

  1. Natarajan L, Witwer N, Eisenmann D. The divergent Caenorhabditis elegans beta-catenin proteins BAR-1, WRM-1 and HMP-2 make distinct protein interactions but retain functional redundancy in vivo. Genetics. 2001;159:159-72 pubmed
    ..elegans, these proteins still retain sufficient similarity to display functional redundancy in vivo. ..
  2. Gleason J, Korswagen H, Eisenmann D. Activation of Wnt signaling bypasses the requirement for RTK/Ras signaling during C. elegans vulval induction. Genes Dev. 2002;16:1281-90 pubmed
    ..These data suggest that hyperactivation of Wnt signaling is sufficient to cause VPCs to adopt induced fates and that a canonical Wnt pathway may play an important role during C. elegans vulval induction. ..
  3. Mizumoto K, Sawa H. Cortical beta-catenin and APC regulate asymmetric nuclear beta-catenin localization during asymmetric cell division in C. elegans. Dev Cell. 2007;12:287-99 pubmed
    ..Because beta-catenin and APC are localized to the cortex in many cell types in different species, our results suggest that these cortical proteins may regulate asymmetric divisions or Wnt signaling in other organisms as well. ..
  4. Cabello J, Neukomm L, Günesdogan U, Burkart K, Charette S, Lochnit G, et al. The Wnt pathway controls cell death engulfment, spindle orientation, and migration through CED-10/Rac. PLoS Biol. 2010;8:e1000297 pubmed publisher
    ..Taken together, our results indicate that in multiple developmental processes, CED-10/Rac can link polar signals mediated by the Wnt pathway to rearrangements of the cytoskeleton. ..
  5. Oosterveen T, Coudreuse D, Yang P, Fraser E, Bergsma J, Dale T, et al. Two functionally distinct Axin-like proteins regulate canonical Wnt signaling in C. elegans. Dev Biol. 2007;308:438-48 pubmed
    ..We conclude that Axin function in C. elegans is divided over two different Axin orthologs that have specific functions in negatively regulating canonical Wnt signaling. ..
  6. Huang X, Tian E, Xu Y, Zhang H. The C. elegans engrailed homolog ceh-16 regulates the self-renewal expansion division of stem cell-like seam cells. Dev Biol. 2009;333:337-47 pubmed publisher