Gene Symbol: apc-11
Description: Anaphase-promoting complex subunit 11
Alias: Anaphase-promoting complex subunit 11
Species: Caenorhabditis elegans

Top Publications

  1. Davis E, Wille L, Chestnut B, Sadler P, Shakes D, Golden A. Multiple subunits of the Caenorhabditis elegans anaphase-promoting complex are required for chromosome segregation during meiosis I. Genetics. 2002;160:805-13 pubmed
    ..Further, chromosome segregation during meiosis I requires APC/C functions in addition to the release of sister chromatid cohesion. ..
  2. Liu J, Vasudevan S, Kipreos E. CUL-2 and ZYG-11 promote meiotic anaphase II and the proper placement of the anterior-posterior axis in C. elegans. Development. 2004;131:3513-25 pubmed
    ..Finally, we show that inactivation of the leucine-rich repeat protein ZYG-11 produces meiotic and polarity reversal defects similar to those observed in cul-2 mutants, suggesting that the two proteins function in the same pathways. ..
  3. Gudgen M, Chandrasekaran A, Frazier T, Boyd L. Interactions within the ubiquitin pathway of Caenorhabditis elegans. Biochem Biophys Res Commun. 2004;325:479-86 pubmed
    ..Using NHL-1 as the E3 in the assays, ubiquitination was observed when both UBC-1 and UBC-13 were present but not with either alone. These data imply that some E2s require dimerization in order to function. ..
  4. de Souza N, Vallier L, Fares H, Greenwald I. SEL-2, the C. elegans neurobeachin/LRBA homolog, is a negative regulator of lin-12/Notch activity and affects endosomal traffic in polarized epithelial cells. Development. 2007;134:691-702 pubmed
    ..Our results also suggest that sel-2 activity may contribute to the appropriate steady-state level of LIN-12 or to trafficking events that affect receptor activation. ..
  5. Frazier T, Shakes D, Hota U, Boyd L. Caenorhabditis elegans UBC-2 functions with the anaphase-promoting complex but also has other activities. J Cell Sci. 2004;117:5427-35 pubmed