Gene Symbol: apa-2
Description: AP-2 complex subunit alpha
Alias: AP-2 complex subunit alpha
Species: Caenorhabditis elegans
Products:     apa-2

Top Publications

  1. Grant B, Hirsh D. Receptor-mediated endocytosis in the Caenorhabditis elegans oocyte. Mol Biol Cell. 1999;10:4311-26 pubmed
    ..We describe a new member of the low-density lipoprotein receptor superfamily, RME-2, identified in our screens for endocytosis defective mutants. We show that RME-2 is the C. elegans yolk receptor. ..
  2. Sieburth D, Ch ng Q, Dybbs M, Tavazoie M, Kennedy S, Wang D, et al. Systematic analysis of genes required for synapse structure and function. Nature. 2005;436:510-7 pubmed
    ..Twenty-four genes encoded proteins that were localized to presynaptic specializations. Loss-of-function mutations in 12 genes caused defects in presynaptic structure...
  3. Holmes A, Flett A, Coudreuse D, Korswagen H, Pettitt J. C. elegans Disabled is required for cell-type specific endocytosis and is essential in animals lacking the AP-3 adaptor complex. J Cell Sci. 2007;120:2741-51 pubmed
  4. Sato M, Sato K, Fonarev P, Huang C, Liou W, Grant B. Caenorhabditis elegans RME-6 is a novel regulator of RAB-5 at the clathrin-coated pit. Nat Cell Biol. 2005;7:559-69 pubmed
    ..These results suggest a mechanism for the activation of Rab5 in clathrin-coated pits or clathrin-coated vesicles that is essential for the delivery of endocytic cargo to early endosomes...
  5. Ch ng Q, Sieburth D, Kaplan J. Profiling synaptic proteins identifies regulators of insulin secretion and lifespan. PLoS Genet. 2008;4:e1000283 pubmed publisher
    ..Using this strategy, we identified several genes that regulate secretion of insulin-like growth factors (IGFs) and influence lifespan in a manner dependent on insulin/IGF signaling. ..
  6. Sato M, Sato K, Liou W, Pant S, Harada A, Grant B. Regulation of endocytic recycling by C. elegans Rab35 and its regulator RME-4, a coated-pit protein. EMBO J. 2008;27:1183-96 pubmed publisher
    ..We propose that RME-4 functions on coated pits and/or vesicles to recruit RAB-35, which in turn functions in the endosome to promote receptor recycling. ..
  7. Chan J, Hu Z, Sieburth D. Recruitment of sphingosine kinase to presynaptic terminals by a conserved muscarinic signaling pathway promotes neurotransmitter release. Genes Dev. 2012;26:1070-85 pubmed publisher
    ..This study shows that SPHK-1 promotes neurotransmitter release in vivo and identifies a novel muscarinic pathway that regulates SphK abundance at presynaptic terminals. ..
  8. Gu M, Liu Q, Watanabe S, Sun L, Hollopeter G, Grant B, et al. AP2 hemicomplexes contribute independently to synaptic vesicle endocytosis. elife. 2013;2:e00190 pubmed publisher
    ..These data suggest that AP2 may function as two partially independent hemicomplexes. DOI:http://dx.doi.org/10.7554/eLife.00190.001. ..
  9. Mayers J, Wang L, Pramanik J, Johnson A, Sarkeshik A, Wang Y, et al. Regulation of ubiquitin-dependent cargo sorting by multiple endocytic adaptors at the plasma membrane. Proc Natl Acad Sci U S A. 2013;110:11857-62 pubmed publisher
    ..Our findings suggest a unique mechanism by which ubiquitin-modified cargoes are sequestered into the endolysosomal pathway...

More Information


  1. Garafalo S, Luth E, Moss B, Monteiro M, Malkin E, Juo P. The AP2 clathrin adaptor protein complex regulates the abundance of GLR-1 glutamate receptors in the ventral nerve cord of Caenorhabditis elegans. Mol Biol Cell. 2015;26:1887-900 pubmed publisher
    ..This study reveals a novel role for the AP2 clathrin adaptor in promoting the abundance of GluRs at synapses in vivo, and implicates AP2 in the regulation of GluR trafficking at an early step in the secretory pathway. ..
  2. Kamikura D, Cooper J. Clathrin interaction and subcellular localization of Ce-DAB-1, an adaptor for protein secretion in Caenorhabditis elegans. Traffic. 2006;7:324-36 pubmed
  3. Lee I, Lehner B, Vavouri T, Shin J, Fraser A, Marcotte E. Predicting genetic modifier loci using functional gene networks. Genome Res. 2010;20:1143-53 pubmed publisher
    ..This work thus suggests that a high-quality integrated human gene network will provide a powerful resource for modifier locus discovery in many different diseases. ..
  4. Chen D, Jian Y, Liu X, Zhang Y, Liang J, Qi X, et al. Clathrin and AP2 are required for phagocytic receptor-mediated apoptotic cell clearance in Caenorhabditis elegans. PLoS Genet. 2013;9:e1003517 pubmed publisher
    ..These findings reveal a non-classical role of clathrin and AP2 and establish them as indispensable regulators in phagocytic receptor-mediated apoptotic cell clearance...
  5. Hollopeter G, Lange J, Zhang Y, Vu T, Gu M, Ailion M, et al. The membrane-associated proteins FCHo and SGIP are allosteric activators of the AP2 clathrin adaptor complex. elife. 2014;3: pubmed publisher
    ..Thus, these proteins stabilize nascent endocytic pits by exposing membrane and cargo binding sites on AP2. ..