Gene Symbol: akt-1
Description: Serine/threonine-protein kinase akt-1
Alias: Serine/threonine-protein kinase akt-1
Species: Caenorhabditis elegans

Top Publications

  1. Dong B, Valencia C, Liu R. Ca(2+)/calmodulin directly interacts with the pleckstrin homology domain of AKT1. J Biol Chem. 2007;282:25131-40 pubmed
    ..CaM is directly involved in regulating the functions of AKT1, presumably by releasing the activated AKT1 from the plasma membrane and/or prohibiting it from re-association with phosphoinositides on plasma membrane. ..
  2. Wang D, Hou L, Nakamura S, Su M, Li F, Chen W, et al. LIN-28 balances longevity and germline stem cell number in Caenorhabditis elegans through let-7/AKT/DAF-16 axis. Aging Cell. 2017;16:113-124 pubmed publisher
  3. Hertweck M, Göbel C, Baumeister R. C. elegans SGK-1 is the critical component in the Akt/PKB kinase complex to control stress response and life span. Dev Cell. 2004;6:577-88 pubmed
    ..Our data also suggest the existence of a second pathway from DAF-2 to DAF-16 that does not depend on AKT-1, AKT-2, and SGK-1. ..
  4. Vanfleteren J, Braeckman B. Mechanisms of life span determination in Caenorhabditis elegans. Neurobiol Aging. 1999;20:487-502 pubmed
    ..Caloric restriction extends longevity substantially, and may act by activating the enhanced life-maintenance program. ..
  5. Nakagawa A, Sullivan K, Xue D. Caspase-activated phosphoinositide binding by CNT-1 promotes apoptosis by inhibiting the AKT pathway. Nat Struct Mol Biol. 2014;21:1082-90 pubmed publisher
    ..Our findings reveal a new mechanism that negatively regulates AKT cell signaling to promote apoptosis and that may restrict cell growth and proliferation in normal cells. ..
  6. Jiu Y, Yue Y, Yang S, Liu L, Yu J, Wu Z, et al. Insulin-like signaling pathway functions in integrative response to an olfactory and a gustatory stimuli in Caenorhabditis elegans. Protein Cell. 2010;1:75-81 pubmed publisher
    ..These results suggest that the insulin-like signaling pathway constitutes an essential component for sensory integration and decision-making behavior plasticity. ..
  7. Soukas A, Kane E, Carr C, Melo J, Ruvkun G. Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans. Genes Dev. 2009;23:496-511 pubmed publisher
    ..These data indicate that Rictor/TORC2 is a nutrient-sensitive complex with outputs to AKT and SGK to modulate the assessment of food quality and signal to fat metabolism, growth, feeding behavior, reproduction, and life span. ..
  8. Watanabe S, Yamamoto T, Kitagawa R. Spindle assembly checkpoint gene mdf-1 regulates germ cell proliferation in response to nutrition signals in C. elegans. EMBO J. 2008;27:1085-96 pubmed publisher
  9. Tullet J, Hertweck M, An J, Baker J, Hwang J, Liu S, et al. Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans. Cell. 2008;132:1025-38 pubmed publisher
    ..Furthermore, SKN-1 that is constitutively active increases life span independently of DAF-16. Our findings indicate that the transcription network regulated by SKN-1 promotes longevity and is an important direct target of IIS. ..

More Information


  1. Zhang Y, Xu J, Puscau C, Kim Y, Wang X, Alam H, et al. Caenorhabditis elegans EAK-3 inhibits dauer arrest via nonautonomous regulation of nuclear DAF-16/FoxO activity. Dev Biol. 2008;315:290-302 pubmed publisher
    ..Similar hormonal pathways may regulate FoxO target gene expression in mammals. ..
  2. Adachi T, Kunitomo H, Tomioka M, Ohno H, Okochi Y, Mori I, et al. Reversal of salt preference is directed by the insulin/PI3K and Gq/PKC signaling in Caenorhabditis elegans. Genetics. 2010;186:1309-19 pubmed publisher
    ..A putative salt receptor GCY-22 guanylyl cyclase is required in ASER for both salt attraction and avoidance. Our results suggest that ASEL and ASER use distinct molecular mechanisms to regulate salt chemotaxis plasticity. ..
  3. Paradis S, Ruvkun G. Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor. Genes Dev. 1998;12:2488-98 pubmed
    ..This demonstrates that Akt/PKB activity is not necessarily dependent on AGE-1 PI3K activity. akt-1 and akt-2 are expressed in overlapping patterns in the nervous system and in tissues that are remodeled during dauer formation. ..
  4. Padmanabhan S, Mukhopadhyay A, Narasimhan S, Tesz G, Czech M, Tissenbaum H. A PP2A regulatory subunit regulates C. elegans insulin/IGF-1 signaling by modulating AKT-1 phosphorylation. Cell. 2009;136:939-51 pubmed publisher
    ..This study reveals a conserved role for the B56 regulatory subunit in regulating insulin signaling through AKT dephosphorylation, thereby having widespread implications in cancer and diabetes research. ..
  5. Artal Sanz M, Tavernarakis N. Prohibitin couples diapause signalling to mitochondrial metabolism during ageing in C. elegans. Nature. 2009;461:793-7 pubmed publisher
    ..elegans. Prohibitin may have a similar key role in modulating energy metabolism during ageing in mammals. ..
  6. Shen X, Valencia C, Gao W, Cotten S, Dong B, Huang B, et al. Ca(2+)/Calmodulin-binding proteins from the C. elegans proteome. Cell Calcium. 2008;43:444-56 pubmed
    ..elegans. ..
  7. Hung W, Hwang C, Gao S, Liao E, Chitturi J, Wang Y, et al. Attenuation of insulin signalling contributes to FSN-1-mediated regulation of synapse development. EMBO J. 2013;32:1745-60 pubmed publisher
    ..We propose that FSN-1 may negatively regulate insulin/IGF signalling, in part, through EGL-3-dependent insulin-like ligand processing. ..
  8. Quevedo C, Kaplan D, Derry W. AKT-1 regulates DNA-damage-induced germline apoptosis in C. elegans. Curr Biol. 2007;17:286-92 pubmed
    ..Finally, we show that AKT-1 regulates apoptosis but not cell-cycle progression downstream of the HUS-1/MRT-2 branch of the DNA damage checkpoint. ..