Gene Symbol: ajm-1
Description: Apical Junction Molecule
Alias: Apical Junction Molecule
Species: Caenorhabditis elegans
Koppen M, Simske J, Sims P, Firestein B, Hall D, Radice A, et al
. Cooperative regulation of AJM-1 controls junctional integrity in Caenorhabditis elegans epithelia. Nat Cell Biol. 2001;3:983-91 pubmed
..We conclude that LET-413 and DLG-1 cooperatively control AJM-1 localization and that AJM-1 controls the integrity of a distinct apical junctional domain in C. elegans. ..
Moorthy S, Chen L, Bennett V. Caenorhabditis elegans beta-G spectrin is dispensable for establishment of epithelial polarity, but essential for muscular and neuronal function. J Cell Biol. 2000;149:915-30 pubmed
..We hypothesize that heteromeric spectrin evolved in metazoans in response to the needs of cells in the context of mechanically integrated tissues that can withstand the rigors imposed by an active organism. ..
Lockwood C, Lynch A, Hardin J. Dynamic analysis identifies novel roles for DLG-1 subdomains in AJM-1 recruitment and LET-413-dependent apical focusing. J Cell Sci. 2008;121:1477-87 pubmed publisher
Giuliani C, Troglio F, Bai Z, Patel F, Zucconi A, Malabarba M, et al
. Requirements for F-BAR proteins TOCA-1 and TOCA-2 in actin dynamics and membrane trafficking during Caenorhabditis elegans oocyte growth and embryonic epidermal morphogenesis. PLoS Genet. 2009;5:e1000675 pubmed publisher
..Thus, we propose that TOCA proteins control tissues morphogenesis by coordinating Clathrin-dependent membrane trafficking with WAVE and N-WASP-dependent actin-dynamics. ..
Segbert C, Johnson K, Theres C, Van Fürden D, Bossinger O. Molecular and functional analysis of apical junction formation in the gut epithelium of Caenorhabditis elegans. Dev Biol. 2004;266:17-26 pubmed
..elegans intestine. ..
Fisher K, Southall S, Wilson J, Poulin G. Methylation and demethylation activities of a C. elegans MLL-like complex attenuate RAS signalling. Dev Biol. 2010;341:142-53 pubmed publisher
..we show that both complexes regulate a common novel target and attenuator of RAS signalling, AJM-1 (Apical Junction Molecule-1). Therefore, the C...
Nguyen P, Liou W, Hall D, Leroux M. Ciliopathy proteins establish a bipartite signaling compartment in a C. elegans thermosensory neuron. J Cell Sci. 2014;127:5317-30 pubmed publisher
..We propose that differential compartmentalization of signal transduction components by ciliary proteins is important for the functions of ciliated sensory neurons. ..
Fernandes J, Sternberg P. The tailless ortholog nhr-67 regulates patterning of gene expression and morphogenesis in the C. elegans vulva. PLoS Genet. 2007;3:e69 pubmed
..We postulate that the differential levels and combinatorial patterns of lin-11, cog-1, and nhr-67 expression are a part of a regulatory code for the mature vulval cell types...