Genomes and Genes
Gene Symbol: air-1
Description: Aurora/Ipl1 Related kinase
Alias: Aurora/Ipl1 Related kinase
Species: Caenorhabditis elegans
- Bishop J, Schumacher J. Phosphorylation of the carboxyl terminus of inner centromere protein (INCENP) by the Aurora B Kinase stimulates Aurora B kinase activity. J Biol Chem. 2002;277:27577-80 pubmed..Since the Aurora B phosphorylation site within INCENP and the functions of INCENP and Aurora B have been conserved among eukaryotes, the feedback loop we have identified is also likely to be evolutionarily conserved. ..
- Furuta T, Baillie D, Schumacher J. Caenorhabditis elegans Aurora A kinase AIR-1 is required for postembryonic cell divisions and germline development. Genesis. 2002;34:244-50 pubmed..The characterization of the three sterile air-1 mutant alleles described here extends these studies by revealing an allelic series that differentially affects postembryonic cell divisions and germline development. ..
- Cowan C, Hyman A. Cyclin E-Cdk2 temporally regulates centrosome assembly and establishment of polarity in Caenorhabditis elegans embryos. Nat Cell Biol. 2006;8:1441-7 pubmed..elegans and Drosophila. Here, we suggest a possible mechanism for cyclin E-Cdk2-dependent differentiation: the establishment of cortical polarity by the centrosome. ..
- Schlaitz A, Srayko M, Dammermann A, Quintin S, Wielsch N, MacLeod I, et al. The C. elegans RSA complex localizes protein phosphatase 2A to centrosomes and regulates mitotic spindle assembly. Cell. 2007;128:115-27 pubmed..By regulating a subset of PP2A functions at the centrosome, the RSA complex could therefore provide a means of coordinating microtubule outgrowth from centrosomes and kinetochore microtubule stability during mitotic spindle assembly. ..
- Hachet V, Canard C, GONCZY P. Centrosomes promote timely mitotic entry in C. elegans embryos. Dev Cell. 2007;12:531-41 pubmed..Together, our findings support a model in which centrosomes serve as integrative centers for mitotic regulators and thus trigger mitotic entry in a timely fashion. ..