Gene Symbol: air-1
Description: Aurora/Ipl1 Related kinase
Alias: Aurora/Ipl1 Related kinase
Species: Caenorhabditis elegans

Top Publications

  1. Srayko M, Kaya A, Stamford J, Hyman A. Identification and characterization of factors required for microtubule growth and nucleation in the early C. elegans embryo. Dev Cell. 2005;9:223-36 pubmed
    ..However, we found that centrosomes do not nucleate MTs to saturation; rather, the depolymerizing kinesin-13 subfamily member KLP-7 is required to limit microtubule outgrowth from centrosomes. ..
  2. Portier N, Audhya A, Maddox P, Green R, Dammermann A, Desai A, et al. A microtubule-independent role for centrosomes and aurora a in nuclear envelope breakdown. Dev Cell. 2007;12:515-29 pubmed
    ..A positive feedback loop, in which an Aurora A-dependent increase in centrosome size promotes Aurora A activation, may temporally couple centrosome maturation to NEBD during mitotic entry. ..
  3. Toya M, Terasawa M, Nagata K, Iida Y, Sugimoto A. A kinase-independent role for Aurora A in the assembly of mitotic spindle microtubules in Caenorhabditis elegans embryos. Nat Cell Biol. 2011;13:708-14 pubmed publisher
    ..Thus, we propose that AIR-1 has a kinase-dependent role at centrosomes and a kinase-independent role for stabilizing spindle microtubules and that coordination of these two roles is crucial for the assembly of mitotic spindles. ..
  4. Kress E, Schwager F, Holtackers R, Seiler J, Prodon F, Zanin E, et al. The UBXN-2/p37/p47 adaptors of CDC-48/p97 regulate mitosis by limiting the centrosomal recruitment of Aurora A. J Cell Biol. 2013;201:559-75 pubmed publisher
    ..The latter defect was also rescued by inhibiting Aurora A. We therefore postulate that the role of this adaptor in cell cycle regulation is conserved. ..
  5. Kotak S, Afshar K, Busso C, GONCZY P. Aurora A kinase regulates proper spindle positioning in C. elegans and in human cells. J Cell Sci. 2016;129:3015-25 pubmed publisher
    ..Overall, our work demonstrates that Aurora A kinases and PP6 phosphatases have an ancient function in modulating spindle positioning, thus contributing to faithful cell division. ..
  6. Kaitna S, Mendoza M, Jantsch Plunger V, Glotzer M. Incenp and an aurora-like kinase form a complex essential for chromosome segregation and efficient completion of cytokinesis. Curr Biol. 2000;10:1172-81 pubmed
    ..We propose that this complex acts by promoting dissolution of sister chromatid cohesion and the assembly of the central spindle. ..
  7. Ozlu N, Srayko M, Kinoshita K, Habermann B, O TOOLE E, MULLER REICHERT T, et al. An essential function of the C. elegans ortholog of TPX2 is to localize activated aurora A kinase to mitotic spindles. Dev Cell. 2005;9:237-48 pubmed
    ..Thus, activation and targeting of Aurora A appears to be an ancient and conserved function of TPX2 that plays a central role in mitotic spindle assembly. ..
  8. Johnsen R, Baillie D. Genetic analysis of a major segment [LGV(left)] of the genome of Caenorhabditis elegans. Genetics. 1991;129:735-52 pubmed
    ..The analysis of essential genes in large regions should help to define C. elegans in terms of all its genes and aid in the understanding of the relationship of genome structure to genome function. ..
  9. Schumacher J, Ashcroft N, Donovan P, Golden A. A highly conserved centrosomal kinase, AIR-1, is required for accurate cell cycle progression and segregation of developmental factors in Caenorhabditis elegans embryos. Development. 1998;125:4391-402 pubmed
    ..Our data suggests AIR-1 plays a role in P-granule segregation and the association of the germline factor PIE-1 with centrosomes. ..

More Information


  1. Bishop J, Schumacher J. Phosphorylation of the carboxyl terminus of inner centromere protein (INCENP) by the Aurora B Kinase stimulates Aurora B kinase activity. J Biol Chem. 2002;277:27577-80 pubmed
    ..Since the Aurora B phosphorylation site within INCENP and the functions of INCENP and Aurora B have been conserved among eukaryotes, the feedback loop we have identified is also likely to be evolutionarily conserved. ..
  2. Furuta T, Baillie D, Schumacher J. Caenorhabditis elegans Aurora A kinase AIR-1 is required for postembryonic cell divisions and germline development. Genesis. 2002;34:244-50 pubmed
    ..The characterization of the three sterile air-1 mutant alleles described here extends these studies by revealing an allelic series that differentially affects postembryonic cell divisions and germline development. ..
  3. Cowan C, Hyman A. Cyclin E-Cdk2 temporally regulates centrosome assembly and establishment of polarity in Caenorhabditis elegans embryos. Nat Cell Biol. 2006;8:1441-7 pubmed
    ..elegans and Drosophila. Here, we suggest a possible mechanism for cyclin E-Cdk2-dependent differentiation: the establishment of cortical polarity by the centrosome. ..
  4. Schlaitz A, Srayko M, Dammermann A, Quintin S, Wielsch N, MacLeod I, et al. The C. elegans RSA complex localizes protein phosphatase 2A to centrosomes and regulates mitotic spindle assembly. Cell. 2007;128:115-27 pubmed
    ..By regulating a subset of PP2A functions at the centrosome, the RSA complex could therefore provide a means of coordinating microtubule outgrowth from centrosomes and kinetochore microtubule stability during mitotic spindle assembly. ..
  5. Hachet V, Canard C, GONCZY P. Centrosomes promote timely mitotic entry in C. elegans embryos. Dev Cell. 2007;12:531-41 pubmed
    ..Together, our findings support a model in which centrosomes serve as integrative centers for mitotic regulators and thus trigger mitotic entry in a timely fashion. ..
  6. Heallen T, Adams H, Furuta T, Verbrugghe K, Schumacher J. An Afg2/Spaf-related Cdc48-like AAA ATPase regulates the stability and activity of the C. elegans Aurora B kinase AIR-2. Dev Cell. 2008;15:603-16 pubmed publisher