Gene Symbol: aex-3
Description: MAP kinase-activating death domain protein
Alias: MAP kinase-activating death domain protein
Species: Caenorhabditis elegans
Doi M, Iwasaki K. Regulation of retrograde signaling at neuromuscular junctions by the novel C2 domain protein AEX-1. Neuron. 2002;33:249-59 pubmed
..This retrograde signaling requires prohormone-convertase function in muscles, suggesting that a peptide is the retrograde signal. This signal regulates synaptic vesicle release via the EGL-30 Gq(alpha) protein at presynaptic terminals. ..
Bhat J, Hutter H. Pioneer Axon Navigation Is Controlled by AEX-3, a Guanine Nucleotide Exchange Factor for RAB-3 in Caenorhabditis elegans. Genetics. 2016;203:1235-47 pubmed publisher
Iwasaki K, Staunton J, Saifee O, Nonet M, Thomas J. aex-3 encodes a novel regulator of presynaptic activity in C. elegans. Neuron. 1997;18:613-22 pubmed
..In C. elegans, aex-3 is expressed in all or nearly all neurons. These results suggest that AEX-3 is a novel regulator of presynaptic activity that interacts with RAB-3 to regulate synaptic vesicle release. ..
Evason K, Huang C, Yamben I, Covey D, Kornfeld K. Anticonvulsant medications extend worm life-span. Science. 2005;307:258-62 pubmed
..These findings suggest that the life-span-extending activity of these compounds is related to the anticonvulsant activity and implicate neural activity in the regulation of aging...
Mahoney T, Luo S, Round E, Brauner M, Gottschalk A, Thomas J, et al
. Intestinal signaling to GABAergic neurons regulates a rhythmic behavior in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2008;105:16350-5 pubmed publisher
..We propose a model whereby the intestinal genes aex-4 and aex-5 control the DMP by regulating the secretion of a signal, which activates the neuronal receptor aex-2. ..
Sheng M, Hosseinzadeh A, Muralidharan S, Gaur R, Selstam E, Tuck S. Aberrant fat metabolism in Caenorhabditis elegans mutants with defects in the defecation motor program. PLoS ONE. 2015;10:e0124515 pubmed publisher
..elegans is to promote the uptake of an important class of dietary nutrients. They also imply that modulation of the program might be one way in which worms adjust nutrient uptake in response to altered metabolic status. ..
Thomas J. Genetic analysis of defecation in Caenorhabditis elegans. Genetics. 1990;124:855-72 pubmed
..On the basis of the phenotypes of the defecation mutants and of double mutants, I suggest a formal genetic pathway for the control of the defecation motor program. ..