Gene Symbol: acy-1
Description: Adenylyl CYclase
Alias: Adenylyl CYclase
Species: Caenorhabditis elegans

Top Publications

  1. Hu S, Pawson T, Steven R. UNC-73/trio RhoGEF-2 activity modulates Caenorhabditis elegans motility through changes in neurotransmitter signaling upstream of the GSA-1/Galphas pathway. Genetics. 2011;189:137-51 pubmed publisher
    ..Together, these data suggest UNC-73 RhoGEF-2 isoforms are required for proper neurotransmitter signaling and may function in the DCV-mediated neuromodulatory regulation of locomotion rate. ..
  2. Stein G, Murphy C. C. elegans positive olfactory associative memory is a molecularly conserved behavioral paradigm. Neurobiol Learn Mem. 2014;115:86-94 pubmed publisher
    ..Study of STAM and ITAM in C. elegans could lead to a more general understanding of the distinctions between these important processes and also to the discovery of novel conserved memory regulators. ..
  3. Alper S, Laws R, Lackford B, Boyd W, Dunlap P, Freedman J, et al. Identification of innate immunity genes and pathways using a comparative genomics approach. Proc Natl Acad Sci U S A. 2008;105:7016-21 pubmed publisher
    ..These genes may prove critical to understanding host defense and represent potential therapeutic targets for infectious and immunological diseases. ..
  4. Mahoney T, Luo S, Round E, Brauner M, Gottschalk A, Thomas J, et al. Intestinal signaling to GABAergic neurons regulates a rhythmic behavior in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2008;105:16350-5 pubmed publisher
    ..We propose a model whereby the intestinal genes aex-4 and aex-5 control the DMP by regulating the secretion of a signal, which activates the neuronal receptor aex-2. ..
  5. Berger A, Hart A, Kaplan J. G alphas-induced neurodegeneration in Caenorhabditis elegans. J Neurosci. 1998;18:2871-80 pubmed
    ..These experiments define an intracellular signaling cascade that triggers a necrotic form of neurodegeneration. ..
  6. Reynolds N, Schade M, Miller K. Convergent, RIC-8-dependent Galpha signaling pathways in the Caenorhabditis elegans synaptic signaling network. Genetics. 2005;169:651-70 pubmed
    ..We propose that the neuronal G alpha(s) pathway transduces critical positional information onto the core G alpha(q) pathway to stabilize the priming of selected synapses that are optimal for locomotion. ..
  7. Raizen D, Zimmerman J, Maycock M, Ta U, You Y, Sundaram M, et al. Lethargus is a Caenorhabditis elegans sleep-like state. Nature. 2008;451:569-72 pubmed publisher
    ..The association of this C. elegans sleep-like state with developmental changes that occur with larval moults suggests that sleep may have evolved to allow for developmental changes. ..
  8. Saifee O, Metz L, Nonet M, Crowder C. A gain-of-function mutation in adenylate cyclase confers isoflurane resistance in Caenorhabditis elegans. Anesthesiology. 2011;115:1162-71 pubmed publisher
    ..Activation of neuronal adenylate cyclase antagonizes isoflurane inhibition of locomotion in C. elegans. ..