Gene Symbol: acr 2
Description: Acetylcholine receptor subunit beta-type acr-2
Alias: Acetylcholine receptor subunit beta-type acr-2
Species: Caenorhabditis elegans
Squire M, Tornøe C, Baylis H, Fleming J, Barnard E, Sattelle D. Molecular cloning and functional co-expression of a Caenorhabditis elegans nicotinic acetylcholine receptor subunit (acr-2). Receptors Channels. 1995;3:107-15 pubmed
Jospin M, Qi Y, Stawicki T, Boulin T, Schuske K, Horvitz H, et al
. A neuronal acetylcholine receptor regulates the balance of muscle excitation and inhibition in Caenorhabditis elegans. PLoS Biol. 2009;7:e1000265 pubmed publisher
..These data indicate that the ACR-2 receptor is important for the coordinated excitation and inhibition of body muscles underlying sinusoidal movement. ..
Stawicki T, Zhou K, Yochem J, Chen L, Jin Y. TRPM channels modulate epileptic-like convulsions via systemic ion homeostasis. Curr Biol. 2011;21:883-8 pubmed publisher
..Together, these data reveal an important role for ion homeostasis in the balance of neuronal network activity and a novel function of nonneuronal TRPM channels in the fine-tuning of this network activity. ..
Barbagallo B, Prescott H, Boyle P, Climer J, Francis M. A dominant mutation in a neuronal acetylcholine receptor subunit leads to motor neuron degeneration in Caenorhabditis elegans. J Neurosci. 2010;30:13932-42 pubmed publisher
Qi Y, Po M, Mac P, Kawano T, Jorgensen E, Zhen M, et al
. Hyperactivation of B-type motor neurons results in aberrant synchrony of the Caenorhabditis elegans motor circuit. J Neurosci. 2013;33:5319-25 pubmed publisher
..These results support that the activity state of B motor neurons plays an instructive role for the coordination of motor circuit. ..
Stawicki T, Takayanagi Kiya S, Zhou K, Jin Y. Neuropeptides function in a homeostatic manner to modulate excitation-inhibition imbalance in C. elegans. PLoS Genet. 2013;9:e1003472 pubmed publisher