Gene Symbol: ace 1
Description: Acetylcholinesterase 1
Alias: Acetylcholinesterase 1
Species: Caenorhabditis elegans
Arpagaus M, Fedon Y, Cousin X, Chatonnet A, Berge J, Fournier D, et al
. cDNA sequence, gene structure, and in vitro expression of ace-1, the gene encoding acetylcholinesterase of class A in the nematode Caenorhabditis elegans. J Biol Chem. 1994;269:9957-65 pubmed
..The secreted enzyme was active and existed as hydrophilic 5 and 11.5 S molecular forms. It hydrolyzed both acetylthiocholine and butyrylthiocholine and was inhibited by acetylthiocholine above 10 mM. ..
Combes D, Fedon Y, Grauso M, Toutant J, Arpagaus M. Four genes encode acetylcholinesterases in the nematodes Caenorhabditis elegans and Caenorhabditis briggsae. cDNA sequences, genomic structures, mutations and in vivo expression. J Mol Biol. 2000;300:727-42 pubmed
..The molecular bases of null mutations g72 (ace-2), p1304 and dc2 (ace-3) have been identified...
Combes D, Fedon Y, Toutant J, Arpagaus M. Multiple ace genes encoding acetylcholinesterases of Caenorhabditis elegans have distinct tissue expression. Eur J Neurosci. 2003;18:497-512 pubmed
..The distinct tissue-specific expression of ace-1, ace-2 and ace-3 (coexpressed only in pm5 cells) indicates that ace genes are not redundant. ..
Selkirk M, Lazari O, Hussein A, Matthews J. Nematode acetylcholinesterases are encoded by multiple genes and perform non-overlapping functions. Chem Biol Interact. 2005;157-158:263-8 pubmed
..Although the function of these enzymes has not been determined, they most likely alter host physiological responses to promote survival of the parasite. ..
Talesa V, Culetto E, Schirru N, Bernardi H, Fedon Y, Toutant J, et al
. Characterization of a null mutation in ace-1, the gene encoding class A acetylcholinesterase in the nematode Caenorhabditis elegans. FEBS Lett. 1995;357:265-8 pubmed
..In contrast, compensation of class B by class A AChE in the null mutant strain ace-2 takes place with unchanged ace-1 mRNA level and enzymatic activity similar to class A AChE. ..
Culetto E, Combes D, Fedon Y, Roig A, Toutant J, Arpagaus M. Structure and promoter activity of the 5' flanking region of ace-1, the gene encoding acetylcholinesterase of class A in Caenorhabditis elegans. J Mol Biol. 1999;290:951-66 pubmed
..Another block of conserved sequence directs expression in pharyngeal muscle cells pm5 and three pairs of cephalic sensory neurons...
Combes D, Fedon Y, Toutant J, Arpagaus M. Acetylcholinesterase genes in the nematode Caenorhabditis elegans. Int Rev Cytol. 2001;209:207-39 pubmed
..It is resistant to usual cholinesterase inhibitors. ace-4 was transcribed but the corresponding enzyme was not detected in vivo. ..