Gene Symbol: abu-8
Description: Activated in Blocked Unfolded protein response
Alias: Activated in Blocked Unfolded protein response
Species: Caenorhabditis elegans

Top Publications

  1. Haskins K, Russell J, Gaddis N, Dressman H, Aballay A. Unfolded protein response genes regulated by CED-1 are required for Caenorhabditis elegans innate immunity. Dev Cell. 2008;15:87-97 pubmed publisher
    ..The results indicate that unfolded protein response genes, regulated in a CED-1-dependent manner, are involved in the C. elegans immune response to live bacteria. ..
  2. Sahu S, Lewis J, Patel I, Bozdag S, Lee J, Leclerc J, et al. Genomic analysis of immune response against Vibrio cholerae hemolysin in Caenorhabditis elegans. PLoS ONE. 2012;7:e38200 pubmed publisher
    ..Our results suggest that VCC is a major virulence factor, which induces a wide variety of immune response- related genes during V. cholerae infection in C. elegans...
  3. Sun J, Singh V, Kajino Sakamoto R, Aballay A. Neuronal GPCR controls innate immunity by regulating noncanonical unfolded protein response genes. Science. 2011;332:729-32 pubmed publisher
    ..Our findings suggest a molecular mechanism by which the nervous system may sense inflammatory responses and respond by controlling stress-response pathways at the organismal level. ..
  4. George Raizen J, Shockley K, Trojanowski N, Lamb A, Raizen D. Dynamically-expressed prion-like proteins form a cuticle in the pharynx of Caenorhabditis elegans. Biol Open. 2014;3:1139-49 pubmed publisher
    ..The strong developmental regulation of the APPG genes raises the possibility that such genes would be identified in transcriptional profiling experiments in which the animals' developmental stage is not precisely staged. ..

Scientific Experts