Gene Symbol: abl-1
Description: Tyrosine-protein kinase abl-1
Alias: Tyrosine-protein kinase abl-1
Species: Caenorhabditis elegans

Top Publications

  1. Deng X, Hofmann E, Villanueva A, Hobert O, Capodieci P, Veach D, et al. Caenorhabditis elegans ABL-1 antagonizes p53-mediated germline apoptosis after ionizing irradiation. Nat Genet. 2004;36:906-12 pubmed
    ..These studies indicate that ABL-1 distinguishes proapoptotic signals triggered by two different DNA-damaging agents and suggest that C. elegans might provide tissue models for development of anticancer drugs. ..
  2. HURWITZ M, Vanderzalm P, Bloom L, Goldman J, Garriga G, Horvitz H. Abl kinase inhibits the engulfment of apoptotic [corrected] cells in Caenorhabditis elegans. PLoS Biol. 2009;7:e99 pubmed publisher
    ..ABL-1 and ABI-1 interact physically in vitro. We propose that ABL-1 opposes the engulfment of apoptotic cells by inhibiting ABI-1 via a pathway that is distinct from the two known engulfment pathways. ..
  3. Marsh E, van den Berg M, May R. A two-gene balance regulates Salmonella typhimurium tolerance in the nematode Caenorhabditis elegans. PLoS ONE. 2011;6:e16839 pubmed publisher
    ..elegans is further mediated by the reciprocal activity of lys-7 and the tyrosine kinase abl-1. Together this implies a greater complexity in C. elegans innate immune function than previously thought. ..
  4. Grossman E, Giurumescu C, Chisholm A. Mechanisms of ephrin receptor protein kinase-independent signaling in amphid axon guidance in Caenorhabditis elegans. Genetics. 2013;195:899-913 pubmed publisher
    ..Overexpression of ABL-1 is sufficient to rescue EFN-1 ventral guidance defects cell autonomously. Our results reveal new aspects of Eph signaling in a single axon guidance decision in vivo. ..
  5. Clifford R, Lee M, Nayak S, Ohmachi M, Giorgini F, Schedl T. FOG-2, a novel F-box containing protein, associates with the GLD-1 RNA binding protein and directs male sex determination in the C. elegans hermaphrodite germline. Development. 2000;127:5265-76 pubmed
    ..fog-2 may have arisen during evolution of self-fertile hermaphroditism from an ancestral female/male species. ..
  6. Salinas L, Maldonado E, Navarro R. Stress-induced germ cell apoptosis by a p53 independent pathway in Caenorhabditis elegans. Cell Death Differ. 2006;13:2129-39 pubmed
    ..We conclude that in C. elegans responses to various stresses that do not involve genotoxicity include an increase in germ cell apoptosis through the physiological pathway. ..
  7. Burton E, Pendergast A, Aballay A. The Caenorhabditis elegans ABL-1 tyrosine kinase is required for Shigella flexneri pathogenesis. Appl Environ Microbiol. 2006;72:5043-51 pubmed
    ..flexneri pathogenesis in nematodes. These data demonstrate the feasibility of using C. elegans to study S. flexneri pathogenesis in vivo and provide insight into host factors that contribute to S. flexneri pathogenesis. ..
  8. Deng X, Yin X, Allan R, Lu D, Maurer C, Haimovitz Friedman A, et al. Ceramide biogenesis is required for radiation-induced apoptosis in the germ line of C. elegans. Science. 2008;322:110-5 pubmed publisher
  9. Zhu Z, Chai Y, Jiang Y, Li W, Hu H, Li W, et al. Functional Coordination of WAVE and WASP in C. elegans Neuroblast Migration. Dev Cell. 2016;39:224-238 pubmed publisher

More Information


  1. Quevedo C, Kaplan D, Derry W. AKT-1 regulates DNA-damage-induced germline apoptosis in C. elegans. Curr Biol. 2007;17:286-92 pubmed
    ..Finally, we show that AKT-1 regulates apoptosis but not cell-cycle progression downstream of the HUS-1/MRT-2 branch of the DNA damage checkpoint. ..