aak 2


Gene Symbol: aak 2
Description: 5'-AMP-activated protein kinase catalytic subunit alpha-2
Alias: 5'-AMP-activated protein kinase catalytic subunit alpha-2
Species: Caenorhabditis elegans

Top Publications

  1. Apfeld J, O Connor G, McDonagh T, DiStefano P, Curtis R. The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans. Genes Dev. 2004;18:3004-9 pubmed
    ..Thus, AAK-2 is a sensor that couples lifespan to information about energy levels and insulin-like signals. ..
  2. Lee H, Cho J, Lambacher N, Lee J, Lee S, Lee T, et al. The Caenorhabditis elegans AMP-activated protein kinase AAK-2 is phosphorylated by LKB1 and is required for resistance to oxidative stress and for normal motility and foraging behavior. J Biol Chem. 2008;283:14988-93 pubmed publisher
    ..Our study suggests that AMPK can influence the behavior of C. elegans worms in addition to its well known function in metabolic control. ..
  3. Curtis R, O Connor G, DiStefano P. Aging networks in Caenorhabditis elegans: AMP-activated protein kinase (aak-2) links multiple aging and metabolism pathways. Aging Cell. 2006;5:119-26 pubmed
    ..These results show that aging is controlled by overlapping but distinct pathways and that AMPK/aak-2 represents a node in a network of evolutionarily conserved biochemical pathways that control aging. ..
  4. Narbonne P, Roy R. Inhibition of germline proliferation during C. elegans dauer development requires PTEN, LKB1 and AMPK signalling. Development. 2006;133:611-9 pubmed
    ..In humans, germline mutations in TGF-beta family members, PTEN or LKB1 result in related tumour-predisposing syndromes. Our findings establish a developmental relationship that may underscore their shared, characteristic aetiology. ..
  5. Schulz T, Zarse K, Voigt A, Urban N, Birringer M, Ristow M. Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress. Cell Metab. 2007;6:280-93 pubmed
  6. Cunningham K, Hua Z, Srinivasan S, Liu J, Lee B, Edwards R, et al. AMP-activated kinase links serotonergic signaling to glutamate release for regulation of feeding behavior in C. elegans. Cell Metab. 2012;16:113-21 pubmed publisher
    ..We show that AMPK-mediated regulation of glutamatergic release is conserved in rat hippocampal neurons. These findings reveal cellular and molecular mediators of serotonergic signaling...
  7. Narbonne P, Roy R. Caenorhabditis elegans dauers need LKB1/AMPK to ration lipid reserves and ensure long-term survival. Nature. 2009;457:210-4 pubmed publisher
    ..These mechanisms may be essential for survival through diapause, hibernation, or long-term fasting in diverse organisms and may also underlie AMPK-dependent life span extension. ..
  8. Hubert T, Wu Z, Chisholm A, Jin Y. S6 kinase inhibits intrinsic axon regeneration capacity via AMP kinase in Caenorhabditis elegans. J Neurosci. 2014;34:758-63 pubmed publisher
    ..We further show that the antidiabetic drug phenformin, which activates AMP kinase, can promote axon regrowth. Our data reveal a new function for an S6 kinase acting through an AMP kinase in regenerative growth of injured axons. ..
  9. Schwarz F, Karadeniz Z, Fischer Rosinsky A, Willmes D, Spranger J, Birkenfeld A. Knockdown of Indy/CeNac2 extends Caenorhabditis elegans life span by inducing AMPK/aak-2. Aging (Albany NY). 2015;7:553-67 pubmed
    ..Together, these data indicate that reducing the expression of Indy/CeNAC2 increases life span in C. elegans, an effect mediated at least in part by AMPK/aak2. ..

More Information


  1. Moreno Arriola E, El Hafidi M, Ortega Cuéllar D, Carvajal K. AMP-Activated Protein Kinase Regulates Oxidative Metabolism in Caenorhabditis elegans through the NHR-49 and MDT-15 Transcriptional Regulators. PLoS ONE. 2016;11:e0148089 pubmed publisher
    ..Our findings establish C. elegans as a tractable model system to dissect the relationship between distinct molecules that play a critical role in the regulation of energy metabolism in human metabolic diseases. ..
  2. Mair W, Panowski S, Shaw R, Dillin A. Optimizing dietary restriction for genetic epistasis analysis and gene discovery in C. elegans. PLoS ONE. 2009;4:e4535 pubmed publisher
    ..1, highlighting the importance of first optimizing DR to identify universal regulators of DR mediated longevity. ..
  3. Rogers A, Chen D, McColl G, Czerwieniec G, Felkey K, Gibson B, et al. Life span extension via eIF4G inhibition is mediated by posttranscriptional remodeling of stress response gene expression in C. elegans. Cell Metab. 2011;14:55-66 pubmed publisher
    ..Our results suggest that IFG-1 mediates the antagonistic effects on growth and somatic maintenance by regulating mRNA translation of particular mRNAs based, in part, on transcript length. ..
  4. Schiavi A, Torgovnick A, Kell A, Megalou E, Castelein N, Guccini I, et al. Autophagy induction extends lifespan and reduces lipid content in response to frataxin silencing in C. elegans. Exp Gerontol. 2013;48:191-201 pubmed publisher
  5. Mosbech M, Kruse R, Harvald E, Olsen A, Gallego S, Hannibal Bach H, et al. Functional loss of two ceramide synthases elicits autophagy-dependent lifespan extension in C. elegans. PLoS ONE. 2013;8:e70087 pubmed publisher
    ..elegans lifespan. We propose that loss of HYL-1 and LAGR-1 result in dietary restriction-induced autophagy and consequently prolonged longevity. ..
  6. Chang H, Pisano S, Chaturbedi A, Chen J, Gordon S, Baruah A, et al. Transcription factors CEP-1/p53 and CEH-23 collaborate with AAK-2/AMPK to modulate longevity in Caenorhabditis elegans. Aging Cell. 2017;16:814-824 pubmed publisher
  7. Larue B, Padilla P. Environmental and genetic preconditioning for long-term anoxia responses requires AMPK in Caenorhabditis elegans. PLoS ONE. 2011;6:e16790 pubmed publisher
    ..Finally, the capacity for an animal to survive long bouts of severe oxygen deprivation is likely dependent on specific subunits of the heterotrimeric protein AMPK and energy stores such as carbohydrates. ..
  8. Lee J, Kong J, Jang J, Han J, Ji Y, Lee J, et al. Lipid droplet protein LID-1 mediates ATGL-1-dependent lipolysis during fasting in Caenorhabditis elegans. Mol Cell Biol. 2014;34:4165-76 pubmed publisher
    ..These data suggest the importance of the concerted action of lipase and lipid droplet protein in the response to fasting signals via PKA to maintain lipid homeostasis. ..
  9. Mouchiroud L, Molin L, Kasturi P, Triba M, Dumas M, Wilson M, et al. Pyruvate imbalance mediates metabolic reprogramming and mimics lifespan extension by dietary restriction in Caenorhabditis elegans. Aging Cell. 2011;10:39-54 pubmed publisher
    ..These findings suggest that inhibition of this transporter homolog in mammals might also promote a DR response. ..
  10. Cunningham K, Bouagnon A, Barros A, Lin L, Malard L, Romano Silva M, et al. Loss of a neural AMP-activated kinase mimics the effects of elevated serotonin on fat, movement, and hormonal secretions. PLoS Genet. 2014;10:e1004394 pubmed publisher
    ..Our data suggest that some of the physiological phenotypes previously attributed to peripheral AAK-2 activity on metabolic targets may instead be due to the role of this kinase in neural serotonin signaling. ..
  11. Hwang A, Ryu E, Artan M, Chang H, Kabir M, Nam H, et al. Feedback regulation via AMPK and HIF-1 mediates ROS-dependent longevity in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2014;111:E4458-67 pubmed publisher
    ..Thus, AMPK and HIF-1 may control immunity and longevity tightly by acting as feedback regulators of ROS. ..
  12. Ishii T, Funato Y, Hashizume O, Yamazaki D, Hirata Y, Nishiwaki K, et al. Mg2+ Extrusion from Intestinal Epithelia by CNNM Proteins Is Essential for Gonadogenesis via AMPK-TORC1 Signaling in Caenorhabditis elegans. PLoS Genet. 2016;12:e1006276 pubmed publisher
    ..AMPK is activated under low-energy conditions and plays a central role in regulating cellular metabolism to adapt to the energy status of cells. Thus, we provide genetic evidence linking Mg2+ homeostasis to energy metabolism via AMPK. ..