Gene Symbol: PestiV1gp1
Description: polyprotein
Species: Bovine viral diarrhea virus 1
Products:     PestiV1gp1

Top Publications

  1. Rinck G, Birghan C, Harada T, Meyers G, Thiel H, Tautz N. A cellular J-domain protein modulates polyprotein processing and cytopathogenicity of a pestivirus. J Virol. 2001;75:9470-82 pubmed publisher
    ..Regulated expression of Jiv in cells infected with noncytopathogenic bovine viral diarrhea virus disclosed a direct correlation between the intracellular level of Jiv, the extent of NS2-3 cleavage, and pestiviral cytopathogenicity...
  2. Magkouras I, M tzener P, R menapf T, Peterhans E, Schweizer M. RNase-dependent inhibition of extracellular, but not intracellular, dsRNA-induced interferon synthesis by Erns of pestiviruses. J Gen Virol. 2008;89:2501-6 pubmed publisher
    ..This probably contributes to the survival of persistently BVDV-infected animals and maintains viral persistence in the host population...
  3. Harada T, Tautz N, Thiel H. E2-p7 region of the bovine viral diarrhea virus polyprotein: processing and functional studies. J Virol. 2000;74:9498-506 pubmed
    ..Transfection of BVDV RNAs with point mutations or a deletion in the E2-p7 region into the complementing cell lines led to the generation of infectious virions. According to our studies, p7 as well as E2 can be complemented in trans...
  4. St Louis M, Massie B, Archambault D. The bovine viral diarrhea virus (BVDV) NS3 protein, when expressed alone in mammalian cells, induces apoptosis which correlates with caspase-8 and caspase-9 activation. Vet Res. 2005;36:213-27 pubmed
  5. Lee Y, Tscherne D, Yun S, Frolov I, Rice C. Dual mechanisms of pestiviral superinfection exclusion at entry and RNA replication. J Virol. 2005;79:3231-42 pubmed publisher
    ..These findings suggest dual mechanisms of pestivirus superinfection exclusion, one at the level of viral entry that requires viral glycoprotein E2 and a second at the level of viral RNA replication...
  6. Gallei A, Widauer S, Thiel H, Becher P. Mutations in the palm region of a plus-strand RNA virus polymerase result in attenuated phenotype. J Gen Virol. 2006;87:3631-6 pubmed
    ..This interesting insight into an essential viral protein may have implications for the development of vaccines and attenuated viral vectors. ..
  7. Fan Z, Bird R. An alternative -1/+2 open reading frame exists within viral N(pro)(1-19) region of bovine viral diarrhea virus SD-1. Virus Res. 2012;163:341-51 pubmed publisher
    ..These findings reveal the existence of an alternative -1/+2 ORF in the N(pro)(1-19) region during the replication of BVDV and open a new avenue to understand the life cycle and pathogenesis of pestiviruses. ..
  8. Zahoor M, Yamane D, Mohamed Y, Suda Y, Kobayashi K, Kato K, et al. Bovine viral diarrhea virus non-structural protein 5A interacts with NIK- and IKKbeta-binding protein. J Gen Virol. 2010;91:1939-48 pubmed publisher
    ..Being the first reported interaction between NIBP and a viral protein, this finding suggests a novel mechanism whereby viruses may subvert host-cell machinery for mediating trafficking as well as NF-kappaB signalling...
  9. Gamlen T, Richards K, Mankouri J, Hudson L, McCauley J, Harris M, et al. Expression of the NS3 protease of cytopathogenic bovine viral diarrhea virus results in the induction of apoptosis but does not block activation of the beta interferon promoter. J Gen Virol. 2010;91:133-44 pubmed publisher
    ..These data suggest that BVDV NS3/4A is responsible for regulating the levels of cellular apoptosis and provide new insights regarding the viral elements associated with CP biotype pathogenesis...

More Information


  1. Cardoso N, Franco Mahecha O, Czepluch W, Quintana M, Malacari D, Trotta M, et al. Bovine Viral Diarrhea Virus Infects Monocyte-Derived Bovine Dendritic Cells by an E2-Glycoprotein-Mediated Mechanism and Transiently Impairs Antigen Presentation. Viral Immunol. 2016;29:417-29 pubmed publisher
    ..Altogether, our results suggest an important role of infected DCs in BVDV-induced immunopathogenesis. ..
  2. Colett M, Larson R, Gold C, Strick D, Anderson D, Purchio A. Molecular cloning and nucleotide sequence of the pestivirus bovine viral diarrhea virus. Virology. 1988;165:191-9 pubmed
    ..A single major open reading frame extending the length of the molecule was found in the viral-sense (positive polarity) sequence. This open reading frame was capable of encoding 3988 amino acids, representing 449 kDa of protein...
  3. Pankraz A, Preis S, Thiel H, Gallei A, Becher P. A single point mutation in nonstructural protein NS2 of bovine viral diarrhea virus results in temperature-sensitive attenuation of viral cytopathogenicity. J Virol. 2009;83:12415-23 pubmed publisher
  4. Xu J, Mendez E, Caron P, Lin C, Murcko M, Collett M, et al. Bovine viral diarrhea virus NS3 serine proteinase: polyprotein cleavage sites, cofactor requirements, and molecular model of an enzyme essential for pestivirus replication. J Virol. 1997;71:5312-22 pubmed
    ..Finally, using a full-length functional BVDV cDNA clone, we demonstrate that a catalytically active NS3 serine proteinase is essential for pestivirus replication...
  5. Kameyama K, Sakoda Y, Matsuno K, Ito A, Tajima M, Nakamura S, et al. Cleavage of the NS2-3 protein in the cells of cattle persistently infected with non-cytopathogenic bovine viral diarrhea virus. Microbiol Immunol. 2008;52:277-82 pubmed publisher
    ..Furthermore, NS3 proteins were detected in many tissues of PI cattle, such as lymphoid tissue, brain, thyroid, lung, and kidney. These results suggest that the NS2-3 protein of ncp BVDV cleaves in vivo. ..
  6. K mmerer B, Tautz N, Becher P, Thiel H, Meyers G. The genetic basis for cytopathogenicity of pestiviruses. Vet Microbiol. 2000;77:117-28 pubmed
    ..Recent results showed a second way for the development of a cp pestivirus which is based on the introduction of a set of point mutations within the NS2 gene...
  7. Lattwein E, Klemens O, Schwindt S, Becher P, Tautz N. Pestivirus virion morphogenesis in the absence of uncleaved nonstructural protein 2-3. J Virol. 2012;86:427-37 pubmed publisher
    ..These findings challenge a previously accepted dogma for pestivirus replication and provide new implications for virion morphogenesis of pestiviruses and HCV...
  8. Jelsma H, Loeffen W, Van Beuningen A, van Rijn P. Preliminary mapping of non-conserved epitopes on envelope glycoprotein E2 of Bovine viral diarrhea virus type 1 and 2. Vet Microbiol. 2013;166:195-9 pubmed publisher
    ..In addition, the antigenic resemblance with envelope glycoprotein E2 of Classical swine fever virus is discussed. ..
  9. Jefferson M, Donaszi Ivanov A, Pollen S, Dalmay T, Saalbach G, Powell P. Host factors that interact with the pestivirus N-terminal protease, Npro, are components of the ribonucleoprotein complex. J Virol. 2014;88:10340-53 pubmed publisher
    ..A proviral role to subvert RNA silencing through binding of these host RNP proteins was not identified for this viral suppressor of interferon. ..
  10. Tautz N, Elbers K, Stoll D, Meyers G, Thiel H. Serine protease of pestiviruses: determination of cleavage sites. J Virol. 1997;71:5415-22 pubmed
    ..It is therefore assumed that the cleavage sites determined for BVDV CP7 are representative of those for all pestiviruses...
  11. Ostachuk A. Bovine viral diarrhea virus structural protein E2 as a complement regulatory protein. Arch Virol. 2016;161:1769-82 pubmed publisher
    ..Furthermore, it is postulated that E2 acts as a self-associated molecular pattern (SAMP), enabling the virus to avoid being targeted by the immune system and to be recognized as self. ..