Gene Symbol: p66
Description: integral outer membrane protein p66
Species: Borrelia burgdorferi B31

Top Publications

  1. Bunikis J, Noppa L, Bergstrom S. Molecular analysis of a 66-kDa protein associated with the outer membrane of Lyme disease Borrelia. FEMS Microbiol Lett. 1995;131:139-45 pubmed
    A 66-kDa protein (p66) associated with the outer membrane of Lyme disease Borrelia was analysed at the molecular level. The chromosomal genes encoding p66 in B. burgdorferi B31, B. afzelii ACAI, and B. garinii Ip90 were sequenced...
  2. Su K, Savino C, Marracci G, Chaudhary P, Yu X, Morris B, et al. Genetic inactivation of the p66 isoform of ShcA is neuroprotective in a murine model of multiple sclerosis. Eur J Neurosci. 2012;35:562-71 pubmed publisher
    ..In this context, the role of the p66 isoform of ShcA protein (p66) may be significant...
  3. Ristow L, Miller H, Padmore L, Chettri R, Salzman N, Caimano M, et al. The ??-integrin ligand of Borrelia burgdorferi is critical for infection of mice but not ticks. Mol Microbiol. 2012;85:1105-18 pubmed publisher
    b>P66 is a Borrelia burgdorferi surface protein with ?? integrin binding and channel forming activities. In this study, the role of P66 in mammalian and tick infection was examined. B...
  4. Ristow L, Bonde M, Lin Y, Sato H, Curtis M, Wesley E, et al. Integrin binding by Borrelia burgdorferi P66 facilitates dissemination but is not required for infectivity. Cell Microbiol. 2015;17:1021-36 pubmed publisher
    b>P66, a Borrelia burgdorferi surface protein with porin and integrin-binding activities, is essential for murine infection. The role of P66 integrin-binding activity in B...
  5. Medrano M, Policastro P, Schwan T, Coburn J. Interaction of Borrelia burgdorferi Hbb with the p66 promoter. Nucleic Acids Res. 2010;38:414-27 pubmed publisher
    Borrelia burgdorferi, an agent of Lyme disease, encodes the beta(3)-chain integrin ligand P66. P66 is expressed by B...
  6. Bárcena Uribarri I, Thein M, Maier E, Bonde M, Bergstrom S, Benz R. Use of nonelectrolytes reveals the channel size and oligomeric constitution of the Borrelia burgdorferi P66 porin. PLoS ONE. 2013;8:e78272 pubmed publisher
    In the Lyme disease spirochete Borrelia burgdorferi, the outer membrane protein P66 is capable of pore formation with an atypical high single-channel conductance of 11 nS in 1 M KCl, which suggested that it could have a larger diameter ..
  7. Kumar D, Ristow L, Shi M, Mukherjee P, Caine J, Lee W, et al. Intravital Imaging of Vascular Transmigration by the Lyme Spirochete: Requirement for the Integrin Binding Residues of the B. burgdorferi P66 Protein. PLoS Pathog. 2015;11:e1005333 pubmed publisher
    ..In contrast, almost no transmigration occurs in the absence of P66, an outer membrane protein that has porin and integrin adhesin functions...
  8. Kenedy M, Luthra A, Anand A, Dunn J, Radolf J, Akins D. Structural modeling and physicochemical characterization provide evidence that P66 forms a ?-barrel in the Borrelia burgdorferi outer membrane. J Bacteriol. 2014;196:859-72 pubmed publisher
    ..Here, we provide evidence that the borrelial OMP P66, a known adhesin with pore-forming activity, forms a ?-barrel in the B. burgdorferi OM...
  9. Coleman J, Toledo A, Benach J. Borrelia burgdorferi HtrA: evidence for twofold proteolysis of outer membrane protein p66. Mol Microbiol. 2016;99:135-50 pubmed publisher
    ..a downregulated protein in A3HtrAOE with a mass, pI and MALDI-TOF spectrum consistent with outer membrane protein p66. P66 and HtrA from cellular lysates partitioned into detergent-resistant membranes, which contain cholesterol-..