ospB

Summary

Gene Symbol: ospB
Description: outer surface protein B
Species: Borrelia burgdorferi B31

Top Publications

  1. ncbi Structural investigation of Borrelia burgdorferi OspB, a bactericidal Fab target
    Michael Becker
    Biology Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    J Biol Chem 280:17363-70. 2005
  2. ncbi Molecular analysis of linear plasmid-encoded major surface proteins, OspA and OspB, of the Lyme disease spirochaete Borrelia burgdorferi
    S Bergstrom
    Department of Microbiology, University of Umeea, Sweden
    Mol Microbiol 3:479-86. 1989
  3. pmc A bactericidal antibody to Borrelia burgdorferi is directed against a variable region of the OspB protein
    A Sadziene
    Department of Microbiology, University of Texas Health Science Center, San Antonio 78284 7758
    Infect Immun 62:2037-45. 1994
  4. ncbi Sequence variation in the outer-surface-protein genes of Borrelia burgdorferi
    D A Caporale
    Department of Zoology, University of New Hampshire, Durham 03824
    Mol Biol Evol 11:51-64. 1994
  5. ncbi An experimental chain of infection reveals that distinct Borrelia burgdorferi populations are selected in arthropod and mammalian hosts
    J R Ryan
    Department of Entomology, College of Agriculture and Life Sciences, North Carolina State University, Raleigh, NC 27606, USA
    Mol Microbiol 30:365-79. 1998
  6. pmc Complement receptor 3 binds the Borrelia burgdorferi outer surface proteins OspA and OspB in an iC3b-independent manner
    Rodolfo C Garcia
    Leukocyte Biology Unit, I C G E B, Area Science Park, 34012 Trieste, Italy
    Infect Immun 73:6138-42. 2005
  7. ncbi Borrelia burgdorferi inhibits human neutrophil functions
    Pauliina Hartiala
    Department of Medical Microbiology, University of Turku, Kiinamyllynkatu 13, 20520 Turku, Finland
    Microbes Infect 10:60-8. 2008
  8. pmc Flagellin and outer surface proteins from Borrelia burgdorferi are not glycosylated
    Jan Sterba
    Biology Center of Academy of Sciences of the Czech Republic, Institute of Parasitology, Branisovska 31, CZ 37005 Ceske Budejovice, Czech Republic
    J Bacteriol 190:2619-23. 2008

Scientific Experts

Detail Information

Publications8

  1. ncbi Structural investigation of Borrelia burgdorferi OspB, a bactericidal Fab target
    Michael Becker
    Biology Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    J Biol Chem 280:17363-70. 2005
    Certain antibody Fab fragments directed against the C terminus of outer surface protein B (OspB), a major lipoprotein of the Lyme disease spirochete, Borrelia burgdorferi, have the unusual property of being bactericidal even in the ..
  2. ncbi Molecular analysis of linear plasmid-encoded major surface proteins, OspA and OspB, of the Lyme disease spirochaete Borrelia burgdorferi
    S Bergstrom
    Department of Microbiology, University of Umeea, Sweden
    Mol Microbiol 3:479-86. 1989
    The ospA and ospB genes encode the major outer membrane proteins of the Lyme disease spirochaete Borrelia burgdorferi...
  3. pmc A bactericidal antibody to Borrelia burgdorferi is directed against a variable region of the OspB protein
    A Sadziene
    Department of Microbiology, University of Texas Health Science Center, San Antonio 78284 7758
    Infect Immun 62:2037-45. 1994
    ..hermsii, a cause of relapsing fever, was further characterized. H6831, an antibody recognizing the OspB proteins of some B. burgdorferi strains, and H4825, an antibody specific for one serotype of B...
  4. ncbi Sequence variation in the outer-surface-protein genes of Borrelia burgdorferi
    D A Caporale
    Department of Zoology, University of New Hampshire, Durham 03824
    Mol Biol Evol 11:51-64. 1994
    ..We sequenced the OspA and OspB genes of nine North American strains and compared them with nine strains previously described...
  5. ncbi An experimental chain of infection reveals that distinct Borrelia burgdorferi populations are selected in arthropod and mammalian hosts
    J R Ryan
    Department of Entomology, College of Agriculture and Life Sciences, North Carolina State University, Raleigh, NC 27606, USA
    Mol Microbiol 30:365-79. 1998
    ..In the case of OspB, two alleles were again identified...
  6. pmc Complement receptor 3 binds the Borrelia burgdorferi outer surface proteins OspA and OspB in an iC3b-independent manner
    Rodolfo C Garcia
    Leukocyte Biology Unit, I C G E B, Area Science Park, 34012 Trieste, Italy
    Infect Immun 73:6138-42. 2005
    ..The present work demonstrates the direct binding of the Borrelia burgdorferi outer surface proteins OspA and OspB to CR3 and that this binding is independent of iC3b.
  7. ncbi Borrelia burgdorferi inhibits human neutrophil functions
    Pauliina Hartiala
    Department of Medical Microbiology, University of Turku, Kiinamyllynkatu 13, 20520 Turku, Finland
    Microbes Infect 10:60-8. 2008
    Outer surface proteins OspA and OspB are among the most prominent Borrelia burgdorferi surface molecules. We constructed OspAB and OspA complementation mutants of B...
  8. pmc Flagellin and outer surface proteins from Borrelia burgdorferi are not glycosylated
    Jan Sterba
    Biology Center of Academy of Sciences of the Czech Republic, Institute of Parasitology, Branisovska 31, CZ 37005 Ceske Budejovice, Czech Republic
    J Bacteriol 190:2619-23. 2008
    ..We did not find any evidence for glycosylation of the major outer membrane proteins OspA and OspB or the structural flagellar proteins FlaB and FlaA. We suggest that glycoproteins present on the surface of B...