Gene Symbol: ospB
Description: outer surface protein B
Species: Borrelia burgdorferi B31
Products:     ospB

Top Publications

  1. Becker M, Bunikis J, Lade B, Dunn J, Barbour A, Lawson C. Structural investigation of Borrelia burgdorferi OspB, a bactericidal Fab target. J Biol Chem. 2005;280:17363-70 pubmed publisher
    Certain antibody Fab fragments directed against the C terminus of outer surface protein B (OspB), a major lipoprotein of the Lyme disease spirochete, Borrelia burgdorferi, have the unusual property of being bactericidal even in the ..
  2. Caporale D, Kocher T. Sequence variation in the outer-surface-protein genes of Borrelia burgdorferi. Mol Biol Evol. 1994;11:51-64 pubmed publisher
    ..We sequenced the OspA and OspB genes of nine North American strains and compared them with nine strains previously described...
  3. Tilly K, Bestor A, Rosa P. Functional Equivalence of OspA and OspB, but Not OspC, in Tick Colonization by Borrelia burgdorferi. Infect Immun. 2016;84:1565-1573 pubmed publisher
    ..burgdorferi in which the ospA open reading frame, on lp54, was replaced with the ospC gene or the ospB gene, encoding a mammal-specific or tick-specific lipoprotein, respectively...
  4. Sadziene A, Jonsson M, Bergstrom S, Bright R, Kennedy R, Barbour A. A bactericidal antibody to Borrelia burgdorferi is directed against a variable region of the OspB protein. Infect Immun. 1994;62:2037-45 pubmed
    ..hermsii, a cause of relapsing fever, was further characterized. H6831, an antibody recognizing the OspB proteins of some B. burgdorferi strains, and H4825, an antibody specific for one serotype of B...
  5. Garcia R, Murgia R, Cinco M. Complement receptor 3 binds the Borrelia burgdorferi outer surface proteins OspA and OspB in an iC3b-independent manner. Infect Immun. 2005;73:6138-42 pubmed publisher
    ..The present work demonstrates the direct binding of the Borrelia burgdorferi outer surface proteins OspA and OspB to CR3 and that this binding is independent of iC3b.
  6. Sterba J, Vancov M, Rudenko N, Golovchenko M, Tremblay T, Kelly J, et al. Flagellin and outer surface proteins from Borrelia burgdorferi are not glycosylated. J Bacteriol. 2008;190:2619-23 pubmed publisher
    ..We did not find any evidence for glycosylation of the major outer membrane proteins OspA and OspB or the structural flagellar proteins FlaB and FlaA. We suggest that glycoproteins present on the surface of B...
  7. Hartiala P, Hyt nen J, Suhonen J, Lepp ranta O, Tuominen Gustafsson H, Viljanen M. Borrelia burgdorferi inhibits human neutrophil functions. Microbes Infect. 2008;10:60-8 pubmed publisher
    Outer surface proteins OspA and OspB are among the most prominent Borrelia burgdorferi surface molecules. We constructed OspAB and OspA complementation mutants of B...
  8. Ryan J, Levine J, Apperson C, Lubke L, Wirtz R, Spears P, et al. An experimental chain of infection reveals that distinct Borrelia burgdorferi populations are selected in arthropod and mammalian hosts. Mol Microbiol. 1998;30:365-79 pubmed
    ..In the case of OspB, two alleles were again identified...
  9. Bergstr m S, Bundoc V, Barbour A. Molecular analysis of linear plasmid-encoded major surface proteins, OspA and OspB, of the Lyme disease spirochaete Borrelia burgdorferi. Mol Microbiol. 1989;3:479-86 pubmed
    The ospA and ospB genes encode the major outer membrane proteins of the Lyme disease spirochaete Borrelia burgdorferi...