dbpA

Summary

Gene Symbol: dbpA
Description: decorin-binding protein A
Species: Borrelia burgdorferi B31
Products:     dbpA

Top Publications

  1. Guo B, Norris S, Rosenberg L, Hook M. Adherence of Borrelia burgdorferi to the proteoglycan decorin. Infect Immun. 1995;63:3467-72 pubmed
    ..Our results indicate that decorin may mediate the adherence of B. burgdorferi to collagen fibers in skin and other tissues. ..
  2. Shi Y, Xu Q, McShan K, Liang F. Both decorin-binding proteins A and B are critical for the overall virulence of Borrelia burgdorferi. Infect Immun. 2008;76:1239-46 pubmed publisher
    Both decorin-binding proteins (DbpA and DbpB) of the Lyme disease spirochete Borrelia burgdorferi bind decorin and glycosaminoglycans, two important building blocks of proteoglycans that are abundantly found in the extracellular matrix (..
  3. Shi Y, Xu Q, Seemanapalli S, McShan K, Liang F. The dbpBA locus of Borrelia burgdorferi is not essential for infection of mice. Infect Immun. 2006;74:6509-12 pubmed
    ..Borrelia burgdorferi expresses a broad array of adhesive molecules, including the decorin-binding proteins A and B (DbpA and DbpB), which are believed to play important roles in mammalian infection...
  4. Roberts W, Mullikin B, Lathigra R, Hanson M. Molecular analysis of sequence heterogeneity among genes encoding decorin binding proteins A and B of Borrelia burgdorferi sensu lato. Infect Immun. 1998;66:5275-85 pubmed
    Immunization of mice with Borrelia burgdorferi decorin binding protein A (DbpA), one of two gene products of the dbpBA locus, has been shown recently to confer protection against challenge...
  5. Guo B, Brown E, Dorward D, Rosenberg L, Hook M. Decorin-binding adhesins from Borrelia burgdorferi. Mol Microbiol. 1998;30:711-23 pubmed
    ..We have now cloned and sequenced two genes encoding the proteins, DbpA and DbpB, which have a similar structure, as revealed by circular dichroism (CD) spectroscopy of recombinant ..
  6. Weening E, Parveen N, Trzeciakowski J, Leong J, Hook M, Skare J. Borrelia burgdorferi lacking DbpBA exhibits an early survival defect during experimental infection. Infect Immun. 2008;76:5694-705 pubmed publisher
    ..burgdorferi and are required for optimal resistance to both innate and adaptive immune mechanisms following needle inoculation. ..
  7. Xu Q, Seemanaplli S, McShan K, Liang F. Increasing the interaction of Borrelia burgdorferi with decorin significantly reduces the 50 percent infectious dose and severely impairs dissemination. Infect Immun. 2007;75:4272-81 pubmed
    ..Here, we report the influence of increasing expression of decorin-binding protein A (DbpA), one of the most investigated spirochetal surface adhesins, on the 50% infectious dose (ID(50)), dissemination, ..
  8. Morgan A, Wang X. Structural mechanisms underlying sequence-dependent variations in GAG affinities of decorin binding protein A, a Borrelia burgdorferi adhesin. Biochem J. 2015;467:439-51 pubmed publisher
    Decorin-binding protein A (DBPA) is an important surface adhesin of the bacterium Borrelia burgdorferi, the causative agent of Lyme disease...
  9. Morgan A, Wang X. The novel heparin-binding motif in decorin-binding protein A from strain B31 of Borrelia burgdorferi explains the higher binding affinity. Biochemistry. 2013;52:8237-45 pubmed publisher
    Decorin-binding protein A (DBPA), a glycosaminoglycan (GAG)-binding lipoprotein found in Borrelia burgdorferi, is crucial to the transmission of Lyme disease in its earliest stages...

More Information

Publications12

  1. Salo J, Jaatinen A, Söderström M, Viljanen M, Hytönen J. Decorin binding proteins of Borrelia burgdorferi promote arthritis development and joint specific post-treatment DNA persistence in mice. PLoS ONE. 2015;10:e0121512 pubmed publisher
    Decorin binding proteins A and B (DbpA and B) of Borrelia burgdorferi are of critical importance for the virulence of the spirochete...
  2. Heikkil T, Sepp l I, Saxen H, Panelius J, Yrj n inen H, Lahdenne P. Species-specific serodiagnosis of Lyme arthritis and neuroborreliosis due to Borrelia burgdorferi sensu stricto, B. afzelii, and B. garinii by using decorin binding protein A. J Clin Microbiol. 2002;40:453-60 pubmed
    The antigenic potential of decorin binding protein A (DbpA) was evaluated in serodiagnosis of human Lyme borreliosis (LB). The dbpA was cloned and sequenced from the three pathogenic Borrelia species common in Europe...
  3. Blevins J, Hagman K, Norgard M. Assessment of decorin-binding protein A to the infectivity of Borrelia burgdorferi in the murine models of needle and tick infection. BMC Microbiol. 2008;8:82 pubmed publisher
    ..Upon complementation of the DbpBA-mutant strain with DbpA, the wild-type level of infectivity was restored...