BB_H06

Summary

Gene Symbol: BB_H06
Description: complement regulator-acquiring surface protein
Species: Borrelia burgdorferi B31

Top Publications

  1. pmc Delineation of species-specific binding properties of the CspZ protein (BBH06) of Lyme disease spirochetes: evidence for new contributions to the pathogenesis of Borrelia spp
    Elizabeth A Rogers
    Department of Microbiology and Immunology, Medical College of Virginia at Virginia Commonwealth University, Richmond, VA 23298 0678, USA
    Infect Immun 75:5272-81. 2007
  2. pmc Borrelia burgdorferi complement regulator-acquiring surface protein 2 (CspZ) as a serological marker of human Lyme disease
    Peter Kraiczy
    Institute of Medical Microbiology and Infection Control, University Hospital of Frankfurt, Frankfurt am Main, Germany
    Clin Vaccine Immunol 15:484-91. 2008
  3. pmc Deciphering the ligand-binding sites in the Borrelia burgdorferi complement regulator-acquiring surface protein 2 required for interactions with the human immune regulators factor H and factor H-like protein 1
    Corinna Siegel
    Institute of Medical Microbiology and Infection Control, University Hospital of Frankfurt, Paul Ehrlich Strasse 40, 60596 Frankfurt, Germany
    J Biol Chem 283:34855-63. 2008
  4. pmc Comparative analysis of the properties and ligand binding characteristics of CspZ, a factor H binding protein, derived from Borrelia burgdorferi isolates of human origin
    Elizabeth A Rogers
    Department of Microbiology and Immunology, Medical College of Virginia at Virginia Commonwealth University, Richmond, VA 23298 0678, USA
    Infect Immun 77:4396-405. 2009

Detail Information

Publications4

  1. pmc Delineation of species-specific binding properties of the CspZ protein (BBH06) of Lyme disease spirochetes: evidence for new contributions to the pathogenesis of Borrelia spp
    Elizabeth A Rogers
    Department of Microbiology and Immunology, Medical College of Virginia at Virginia Commonwealth University, Richmond, VA 23298 0678, USA
    Infect Immun 75:5272-81. 2007
    ....
  2. pmc Borrelia burgdorferi complement regulator-acquiring surface protein 2 (CspZ) as a serological marker of human Lyme disease
    Peter Kraiczy
    Institute of Medical Microbiology and Infection Control, University Hospital of Frankfurt, Frankfurt am Main, Germany
    Clin Vaccine Immunol 15:484-91. 2008
    ..burgdorferi type strain B31 BbCRASP-2, consistent with the high percentage of serologically positive patients. These data indicate that BbCRASP-2 may be valuable for use in a widely effective serological assay...
  3. pmc Deciphering the ligand-binding sites in the Borrelia burgdorferi complement regulator-acquiring surface protein 2 required for interactions with the human immune regulators factor H and factor H-like protein 1
    Corinna Siegel
    Institute of Medical Microbiology and Infection Control, University Hospital of Frankfurt, Paul Ehrlich Strasse 40, 60596 Frankfurt, Germany
    J Biol Chem 283:34855-63. 2008
    ..Collectively, we mapped a structurally sensitive CFH/CFHL1 binding site within borrelial BbCRASP-2 and identified single amino acid residues potentially involved in the interaction with both complement regulators...
  4. pmc Comparative analysis of the properties and ligand binding characteristics of CspZ, a factor H binding protein, derived from Borrelia burgdorferi isolates of human origin
    Elizabeth A Rogers
    Department of Microbiology and Immunology, Medical College of Virginia at Virginia Commonwealth University, Richmond, VA 23298 0678, USA
    Infect Immun 77:4396-405. 2009
    ..However, in spite of its possible contributory role in pathogenesis, the immunological analyses indicated that CspZ is likely to have limited potential as a diagnostic marker and vaccine candidate for Lyme disease...