BB_B19

Summary

Gene Symbol: BB_B19
Description: outer surface protein OspC
Species: Borrelia burgdorferi B31

Top Publications

  1. ncbi Outer surface protein C gene sequence analysis of Borrelia burgdorferi sensu lato isolates from Japan
    M Fukunaga
    Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Japan
    J Clin Microbiol 33:2415-20. 1995
  2. ncbi Genetic analysis of the outer surface protein C gene of Lyme disease spirochaetes (Borrelia burgdorferi sensu lato) isolated from rodents in Taiwan
    Chien Ming Shih
    Department of Parasitology and Tropical Medicine, National Defense Medical Center, Taipei, Taiwan, Republic of China
    J Med Microbiol 51:318-25. 2002
  3. ncbi Genetic diversity of the outer surface protein C gene of southern Borrelia isolates and its possible epidemiological, clinical, and pathogenetic implications
    Tao Lin
    Institute of Arthropodology and Parasitology, Georgia Southern University, Statesboro, Georgia 30460 8056, USA
    J Clin Microbiol 40:2572-83. 2002
  4. ncbi Disease severity in a murine model of lyme borreliosis is associated with the genotype of the infecting Borrelia burgdorferi sensu stricto strain
    Guiqing Wang
    Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY 10595, USA
    J Infect Dis 186:782-91. 2002
  5. ncbi Recombinant OspC from Borrelia burgdorferi sensu stricto, B. afzelii and B. garinii in the serodiagnosis of Lyme borreliosis
    Jaana Panelius
    Haartman Institute, Department of Bacteriology and Immunology, Turku University Central Hospital, Finland
    J Med Microbiol 51:731-9. 2002
  6. ncbi Sequence typing reveals extensive strain diversity of the Lyme borreliosis agents Borrelia burgdorferi in North America and Borrelia afzelii in Europe
    Jonas Bunikis
    Department of Microbiology, B240 Medical Sciences I, University of California Irvine, Irvine, CA 92697 4025, USA
    Microbiology 150:1741-55. 2004
  7. ncbi Analysis of the ospC regulatory element controlled by the RpoN-RpoS regulatory pathway in Borrelia burgdorferi
    Xiaofeng F Yang
    Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, 75390 9048, USA
    J Bacteriol 187:4822-9. 2005
  8. ncbi Borrelia burgdorferi sensu stricto invasiveness is correlated with OspC-plasminogen affinity
    Vanessa Lagal
    Laboratoire des Spirochètes, Institut Pasteur, 25 28 Rue du Dr Roux, 75724 Paris Cedex 15, France
    Microbes Infect 8:645-52. 2006
  9. ncbi Identification of an ospC operator critical for immune evasion of Borrelia burgdorferi
    Qilong Xu
    Department of Pathobiological Sciences, Louisiana State University, Baton Rouge, LA 70803, USA
    Mol Microbiol 64:220-31. 2007
  10. ncbi The failure of immune response evasion by linear plasmid 28-1-deficient Borrelia burgdorferi is attributable to persistent expression of an outer surface protein
    Monica E Embers
    Divisions of Bacteriology and Parasitology, Tulane National Primate Research Center, Tulane University Health Sciences Center, Covington, Louisiana 70433, USA
    Infect Immun 76:3984-91. 2008

Scientific Experts

  • J Bunikis
  • J Panelius
  • Chien Ming Shih
  • Guiqing Wang
  • E K Hofmeister
  • M Fukunaga
  • Christopher G Earnhart
  • Kit Tilly
  • Monica E Embers
  • Qilong Xu
  • Vanessa Lagal
  • Xiaofeng F Yang
  • Tao Lin
  • D Kumaran
  • Delacy V Leblanc
  • J J Dunn
  • Richard T Marconi
  • Justin D Radolf
  • B J Luft
  • Daniel C Desrosiers
  • Katie E Alix
  • Daniel P Dulebohn
  • Aaron Bestor
  • Patricia A Rosa
  • Mario T Philipp
  • Xavier Alvarez
  • I N Wang
  • Tara Ooms
  • Kristy McShan
  • Fang Ting Liang
  • Denis Portnoi
  • Grazyna Faure
  • M Theisen
  • Daniele Postic
  • Guy Baranton
  • S Jauris-Heipke
  • Utpal Pal
  • Sophie M Alani
  • D Scott Samuels
  • Meghan C Lybecker
  • Jon Blevins
  • Michael V Norgard
  • Andrew T Revel
  • B Wilske
  • N Marti Ras
  • James H Oliver
  • Lihui Gao
  • E Soutschek
  • E Schwab
  • S Eswaramoorthy
  • V Preac-Mursic
  • S Koide
  • G Will
  • S Swaminathan
  • C L Lawson
  • I Livey
  • W Qiu
  • E M Bosler
  • D E Dykhuizen
  • K Hansen
  • A M Lebech
  • M Foretz
  • D Postic
  • G Baranton
  • S J Padula
  • C P Gibbs
  • D Rossler
  • M Borre
  • F Dorner
  • G Liegl
  • M J Mathiesen
  • B Mikkelsen
  • R Schuster
  • G Wanner
  • M Motz
  • I Pradel
  • F Dias
  • A Sampieri
  • J Vuust
  • R W Ryan
  • A Hofmann
  • A Szczepanski
  • R Fuchs
  • B Frederiksen
  • S Jauris

Detail Information

Publications24

  1. ncbi Outer surface protein C gene sequence analysis of Borrelia burgdorferi sensu lato isolates from Japan
    M Fukunaga
    Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Japan
    J Clin Microbiol 33:2415-20. 1995
    ..garinii and to have adapted to an Asiatic habitat, and there appeared to be a sufficient ecological pressure to allow bacterial species level development...
  2. ncbi Genetic analysis of the outer surface protein C gene of Lyme disease spirochaetes (Borrelia burgdorferi sensu lato) isolated from rodents in Taiwan
    Chien Ming Shih
    Department of Parasitology and Tropical Medicine, National Defense Medical Center, Taipei, Taiwan, Republic of China
    J Med Microbiol 51:318-25. 2002
    ..burgdorferi sensu stricto...
  3. ncbi Genetic diversity of the outer surface protein C gene of southern Borrelia isolates and its possible epidemiological, clinical, and pathogenetic implications
    Tao Lin
    Institute of Arthropodology and Parasitology, Georgia Southern University, Statesboro, Georgia 30460 8056, USA
    J Clin Microbiol 40:2572-83. 2002
    ..Currently, strain MI-2 appears to be the only southern isolate among the 20 we analyzed that clusters with an OspC invasive group and thus might be invasive for humans...
  4. ncbi Disease severity in a murine model of lyme borreliosis is associated with the genotype of the infecting Borrelia burgdorferi sensu stricto strain
    Guiqing Wang
    Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY 10595, USA
    J Infect Dis 186:782-91. 2002
    ..burgdorferi isolate. The RST1 genotype is genetically homogeneous and thus may represent a recently evolved clonal lineage that is highly pathogenic in humans and animals...
  5. ncbi Recombinant OspC from Borrelia burgdorferi sensu stricto, B. afzelii and B. garinii in the serodiagnosis of Lyme borreliosis
    Jaana Panelius
    Haartman Institute, Department of Bacteriology and Immunology, Turku University Central Hospital, Finland
    J Med Microbiol 51:731-9. 2002
    ..Because of the heterogeneity of OspC, a polyvalent antigen with several OspC variants from at least B. afzelii and B. garinii is needed to improve the sensitivity of OspC ELISA in the serodiagnosis of LB in Europe...
  6. ncbi Sequence typing reveals extensive strain diversity of the Lyme borreliosis agents Borrelia burgdorferi in North America and Borrelia afzelii in Europe
    Jonas Bunikis
    Department of Microbiology, B240 Medical Sciences I, University of California Irvine, Irvine, CA 92697 4025, USA
    Microbiology 150:1741-55. 2004
    ..burgdorferi. It is concluded that B. burgdorferi and B. afzelii have greater genetic diversity than had previously been estimated, and that the IGS locus alone is sufficient for strain typing and phylogenetic studies...
  7. ncbi Analysis of the ospC regulatory element controlled by the RpoN-RpoS regulatory pathway in Borrelia burgdorferi
    Xiaofeng F Yang
    Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, 75390 9048, USA
    J Bacteriol 187:4822-9. 2005
    ..The implication of our findings to understanding how B. burgdorferi differentially regulates ospC and other ospC-like genes via the RpoN-RpoS regulatory pathway is discussed...
  8. ncbi Borrelia burgdorferi sensu stricto invasiveness is correlated with OspC-plasminogen affinity
    Vanessa Lagal
    Laboratoire des Spirochètes, Institut Pasteur, 25 28 Rue du Dr Roux, 75724 Paris Cedex 15, France
    Microbes Infect 8:645-52. 2006
    ..These results suggest that the correlation between ospC polymorphism and Borrelia invasiveness in humans is linked, at least in part, to differences in OspC affinity for plasminogen...
  9. ncbi Identification of an ospC operator critical for immune evasion of Borrelia burgdorferi
    Qilong Xu
    Department of Pathobiological Sciences, Louisiana State University, Baton Rouge, LA 70803, USA
    Mol Microbiol 64:220-31. 2007
    ..burgdorferi...
  10. ncbi The failure of immune response evasion by linear plasmid 28-1-deficient Borrelia burgdorferi is attributable to persistent expression of an outer surface protein
    Monica E Embers
    Divisions of Bacteriology and Parasitology, Tulane National Primate Research Center, Tulane University Health Sciences Center, Covington, Louisiana 70433, USA
    Infect Immun 76:3984-91. 2008
    ..These findings indicate that incomplete repression of OspC by lp28-1(-) organisms renders them susceptible to immune-mediated clearance. The lp28-1 plasmid must harbor one or more genes involved in OspC downregulation...
  11. ncbi OspC-independent infection and dissemination by host-adapted Borrelia burgdorferi
    Kit Tilly
    Laboratory of Zoonotic Pathogens, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, Montana 59840, USA
    Infect Immun 77:2672-82. 2009
    ..The strict temporal control of B. burgdorferi outer surface protein gene expression may reflect immunological constraints rather than distinct functions...
  12. ncbi Crystal structure of outer surface protein C (OspC) from the Lyme disease spirochete, Borrelia burgdorferi
    D Kumaran
    Biology Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    EMBO J 20:971-8. 2001
    ..This feature is present only on OspCs from strains known to cause invasive human disease...
  13. ncbi Population dynamics of a naturally occurring heterogeneous mixture of Borrelia burgdorferi clones
    E K Hofmeister
    Department of Laboratory Medicine, Mayo Foundation, Rochester, Minnesota 55905, USA
    Infect Immun 67:5709-16. 1999
    ..The lack of cross-immunization between clones existing within a naturally occurring population may play a role in the maintenance of the genetic heterogeneity of B. burgdorferi in nature...
  14. ncbi Molecular analysis of genes encoding outer surface protein C (OspC) of Borrelia burgdorferi sensu lato: relationship to ospA genotype and evidence of lateral gene exchange of ospC
    S Jauris-Heipke
    Max von Pettenkofer Institut für Hygiene und Medizinische Mikrobiologie der Universität München, Germany
    J Clin Microbiol 33:1860-6. 1995
    ..afzelii strain. In addition, other recombination events between ancestors of strains belonging to the same or different species were evidenced by this type of analysis...
  15. ncbi Evolution of the Borrelia burgdorferi outer surface protein OspC
    M Theisen
    Statens Seruminstitut, Department of Infection Immunology, Copenhagen, Denmark
    J Bacteriol 177:3036-44. 1995
    ..In contrast, the phylogenetic tree obtained for the B. hermsii variable major protein, Vmp33, and 18 OspC amino acid sequences suggested that Vmp33 and OspC from B. burgdorferi sensu stricto strains share a common evolutionary origin...
  16. ncbi Genetic heterogenity of the genes coding for the outer surface protein C (OspC) and the flagellin of Borrelia burgdorferi
    S Jauris-Heipke
    Max von Pettenkofer Institut, Munchen, Germany
    Med Microbiol Immunol 182:37-50. 1993
    ..The different ospC and fla gene products were immunoreactive with monoclonal antibodies and human sera and, thus, enlarge the spectrum of recombinant antigens to improve antibody detection in patients with Lyme borreliosis...
  17. ncbi Molecular characterization and expression of p23 (OspC) from a North American strain of Borrelia burgdorferi
    S J Padula
    Department of Medicine, University of Connecticut Health Center, Farmington 06030 1310
    Infect Immun 61:5097-105. 1993
    ..An immunoglobulin M enzyme-linked immunosorbent assay using recombinant OspC as the target antigen shows promise for the serodiagnosis of early stages of Lyme disease...
  18. ncbi Polymorphism in ospC gene of Borrelia burgdorferi and immunoreactivity of OspC protein: implications for taxonomy and for use of OspC protein as a diagnostic antigen
    M Theisen
    Department of Infection Immunology, Statens Seruminstitut, Copenhagen, Denmark
    J Clin Microbiol 31:2570-6. 1993
    ..Therefore, a serodiagnostic assay for Lyme borreliosis utilizing OspC as a test antigen should include all three OspC phenotypes in order to obtain a species-wide sensitivity...
  19. ncbi Immunological and molecular polymorphisms of OspC, an immunodominant major outer surface protein of Borrelia burgdorferi
    B Wilske
    Max von Pettenkofer Institut fur Hygiene und Medizinische Mikrobiologie, Universitat Munchen, Germany
    Infect Immun 61:2182-91. 1993
    ....
  20. ncbi Evidence for lateral transfer and recombination in OspC variation in Lyme disease Borrelia
    I Livey
    Immuno AG, Biomedical Research Center, Orth an der Donau, Austria
    Mol Microbiol 18:257-69. 1995
    ..e. B. afzelii and B. garinii) as well as between different Borrelia species (i.e. B. afzelii and B. garinii, B. burgdorferi and genogroup DN127)...
  21. ncbi Characterization of spirochetes isolated from ticks (Ixodes tanuki, Ixodes turdus, and Ixodes columnae) and comparison of the sequences with those of Borrelia burgdorferi sensu lato strains
    M Fukunaga
    Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Japan
    Appl Environ Microbiol 62:2338-44. 1996
    ..The results of 16S rRNA gene sequence comparison suggest that the strain Am501 from I. columnae is related to group Hk501, although its level of DNA relatedness is less than 70%...
  22. ncbi Borrelia burgdorferi sensu stricto, a bacterial species "made in the U.S.A."?
    N Marti Ras
    Unité de bactériologie moléculaire et médicale, Institut Pasteur, Paris, France
    Int J Syst Bacteriol 47:1112-7. 1997
    ..We discuss the significance of these features and suggest that they might be evidence of the anteriority of North American B. burgdorferi strains...
  23. ncbi Genetic diversity of ospC in a local population of Borrelia burgdorferi sensu stricto
    I N Wang
    Department of Ecology and Evolution, State University of New York, Stony Brook, New York 11794 5245, USA
    Genetics 151:15-30. 1999
    ..The variation represented by major ospC groups needs to be considered if the OspC protein is to be used as a serodiagnostic antigen or a vaccine...
  24. ncbi Identification of residues within ligand-binding domain 1 (LBD1) of the Borrelia burgdorferi OspC protein required for function in the mammalian environment
    Christopher G Earnhart
    Department of Microbiology and Immunology, Medical College of Virginia at Virginia Commonwealth University, Richmond, VA, USA
    Mol Microbiol 76:393-408. 2010
    ..These results shed new light on the structure-functions relationships of OspC and challenge existing hypotheses regarding OspC function in mammals...