Gene Symbol: BB_0104
Description: periplasmic serine protease DO
Species: Borrelia burgdorferi B31

Top Publications

  1. Russell T, Johnson B. Lyme disease spirochaetes possess an aggrecan-binding protease with aggrecanase activity. Mol Microbiol. 2013;90:228-40 pubmed publisher
    ..Moreover, our studies provide the first evidence that B.?burgdorferi possess proteolytic activity which may contribute to the pathogenesis of Lyme arthritis...
  2. Coleman J, Crowley J, Toledo A, Benach J. The HtrA protease of Borrelia burgdorferi degrades outer membrane protein BmpD and chemotaxis phosphatase CheX. Mol Microbiol. 2013;88:619-33 pubmed publisher
    ..HtrABb may function in regulating outer membrane lipoproteins and in modulating the chemotactic response of B. burgdorferi...
  3. Russell T, Delorey M, Johnson B. Borrelia burgdorferi?BbHtrA degrades host ECM proteins and stimulates release of inflammatory cytokines in vitro. Mol Microbiol. 2013;90:241-51 pubmed publisher
    ..These results provide the first evidence that, by utilizing BbHtrA, B.?burgdorferi may actively participate in its dissemination and in the tissue damage and inflammation observed in Lyme disease...
  4. Coleman J, Toledo A, Benach J. Borrelia burgdorferi HtrA: evidence for twofold proteolysis of outer membrane protein p66. Mol Microbiol. 2016;99:135-50 pubmed publisher
    ..A3HtrAOE also showed reduced levels of p66 transcript in comparison with wild-type B31A3, indicating that HtrA-mediated regulation of p66 may occur at multiple levels. ..