transcriptional regulator Spx
Gene Symbol: transcriptional regulator Spx
Description: regulatory protein spx
Species: Bacillus subtilis subsp. subtilis str. 168
Nakano M, Hajarizadeh F, Zhu Y, Zuber P. Loss-of-function mutations in yjbD result in ClpX- and ClpP-independent competence development of Bacillus subtilis. Mol Microbiol. 2001;42:383-94 pubmed
..Alternatively, the result could suggest that YjbD has a negative effect on regulated proteolysis and that MecA is degraded independently of ClpP when YjbD is absent. ..
Nakano S, Zheng G, Nakano M, Zuber P. Multiple pathways of Spx (YjbD) proteolysis in Bacillus subtilis. J Bacteriol. 2002;184:3664-70 pubmed
..Spx probably is degraded by ClpCP under as yet unidentified conditions. This study suggests that the level of Spx is tightly controlled by two different ClpP proteases. ..
Nakano S, Küster Schöck E, Grossman A, Zuber P. Spx-dependent global transcriptional control is induced by thiol-specific oxidative stress in Bacillus subtilis. Proc Natl Acad Sci U S A. 2003;100:13603-8 pubmed
Nakano S, Nakano M, Zhang Y, Leelakriangsak M, Zuber P. A regulatory protein that interferes with activator-stimulated transcription in bacteria. Proc Natl Acad Sci U S A. 2003;100:4233-8 pubmed
..Spx represents a class of transcriptional regulators that inhibit activator-stimulated transcription by interaction with alpha. ..
Nakano M, Nakano S, Zuber P. Spx (YjbD), a negative effector of competence in Bacillus subtilis, enhances ClpC-MecA-ComK interaction. Mol Microbiol. 2002;44:1341-9 pubmed
..Spx is a highly conserved protein among Gram-positive bacteria, in which it may function closely with the protease adaptor protein, MecA. ..
Chan C, Garg S, Lin A, Zuber P. Geobacillus thermodenitrificans YjbH recognizes the C-terminal end of Bacillus subtilis Spx to accelerate Spx proteolysis by ClpXP. Microbiology. 2012;158:1268-78 pubmed publisher
..Kinetic measurements for Spx proteolysis by ClpXP in the presence and absence of GtYjbH suggest that YjbH overcomes non-productive Spx-ClpX interaction, resulting in rapid degradation. ..
Newberry K, Nakano S, Zuber P, Brennan R. Crystal structure of the Bacillus subtilis anti-alpha, global transcriptional regulator, Spx, in complex with the alpha C-terminal domain of RNA polymerase. Proc Natl Acad Sci U S A. 2005;102:15839-44 pubmed publisher
Rochat T, Nicolas P, Delumeau O, Rabatinov A, Korelusov J, Leduc A, et al
. Genome-wide identification of genes directly regulated by the pleiotropic transcription factor Spx in Bacillus subtilis. Nucleic Acids Res. 2012;40:9571-83 pubmed publisher
The transcriptional regulator Spx plays a key role in maintaining the redox homeostasis of Bacillus subtilis cells exposed to disulfide stress...
You C, Sekowska A, Francetic O, Martin Verstraete I, Wang Y, Danchin A. Spx mediates oxidative stress regulation of the methionine sulfoxide reductases operon in Bacillus subtilis. BMC Microbiol. 2008;8:128 pubmed publisher
..The Spx mediated PQ-specific regulation pathway of the msrAB operon in B. subtilis is reported. Our results suggest that PQ induced the expression of msrAB partially through an oxidation on Spx via modification of its CXXC motif...