Gene Symbol: sigV
Description: RNA polymerase sigma factor SigV
Species: Bacillus subtilis subsp. subtilis str. 168
Guariglia Oropeza V, Helmann J. Bacillus subtilis ?(V) confers lysozyme resistance by activation of two cell wall modification pathways, peptidoglycan O-acetylation and D-alanylation of teichoic acids. J Bacteriol. 2011;193:6223-32 pubmed publisher
..subtilis to lysozyme. Strains with null mutations in either sigV or all seven ECF ? factor genes (?7ECF) have essentially equal increases in sensitivity to lysozyme...
Hastie J, Williams K, Ellermeier C. The activity of ?V, an extracytoplasmic function ? factor of Bacillus subtilis, is controlled by regulated proteolysis of the anti-? factor RsiV. J Bacteriol. 2013;195:3135-44 pubmed publisher
..Collectively, these data provide evidence that the mechanism for ?(V) activation in B. subtilis is controlled by regulated intramembrane proteolysis (RIP) and requires the site 2 protease RasP. ..
Ho T, Hastie J, Intile P, Ellermeier C. The Bacillus subtilis extracytoplasmic function ? factor ?(V) is induced by lysozyme and provides resistance to lysozyme. J Bacteriol. 2011;193:6215-22 pubmed publisher
..A mutation in sigV results in increased sensitivity to lysozyme killing, suggesting that ?(V) is required for lysozyme resistance...
Hastie J, Williams K, SepÃºlveda C, Houtman J, Forest K, Ellermeier C. Evidence of a bacterial receptor for lysozyme: binding of lysozyme to the anti-Ïƒ factor RsiV controls activation of the ecf Ïƒ factor ÏƒV. PLoS Genet. 2014;10:e1004643 pubmed publisher
..Thus, unlike other ECF Ïƒ factors which require regulated intramembrane proteolysis for activation, the sensor for ÏƒV activation is not the site-1 protease but the anti-Ïƒ factor. ..