Gene Symbol: parB
Description: stage 0 sporulation protein J
Species: Bacillus subtilis subsp. subtilis str. 168

Top Publications

  1. Ogasawara N, Yoshikawa H. Genes and their organization in the replication origin region of the bacterial chromosome. Mol Microbiol. 1992;6:629-34 pubmed
    ..putida) was found flanking gidA in both organisms. This result shows clearly that E. coli oriC and flanking genes gidA and gidB have been translocated by the inversion of some 40 kb fragment. ..
  2. Breier A, Grossman A. Whole-genome analysis of the chromosome partitioning and sporulation protein Spo0J (ParB) reveals spreading and origin-distal sites on the Bacillus subtilis chromosome. Mol Microbiol. 2007;64:703-18 pubmed
    We investigated the genome-wide DNA binding of the chromosome partitioning and sporulation protein and ParB family member Spo0J in Bacillus subtilis using chromatin immunoprecipitation and DNA microarrays...
  3. Gruber S, Errington J. Recruitment of condensin to replication origin regions by ParB/SpoOJ promotes chromosome segregation in B. subtilis. Cell. 2009;137:685-96 pubmed publisher
    ..Our results demonstrate a direct functional interaction between two widely conserved systems involved in chromosome replication and segregation...
  4. Ireton K, Gunther N, Grossman A. spo0J is required for normal chromosome segregation as well as the initiation of sporulation in Bacillus subtilis. J Bacteriol. 1994;176:5320-9 pubmed
    ..are known to be similar in sequence to a family of proteins involved in plasmid partitioning, including ParA and ParB of prophage P1, SopA and SopB of F, and IncC and KorB of RK2, spo0J was found to be required for normal chromosome ..
  5. Sullivan N, Marquis K, Rudner D. Recruitment of SMC by ParB-parS organizes the origin region and promotes efficient chromosome segregation. Cell. 2009;137:697-707 pubmed publisher
    ..In Bacillus subtilis, parS sites are bound by the partitioning protein Spo0J (ParB), and we show here that Spo0J recruits the SMC complex to the origin...
  6. Minnen A, Bürmann F, Wilhelm L, Anchimiuk A, Diebold Durand M, Gruber S. Control of Smc Coiled Coil Architecture by the ATPase Heads Facilitates Targeting to Chromosomal ParB/parS and Release onto Flanking DNA. Cell Rep. 2016;14:2003-16 pubmed publisher
    ..We demonstrate that targeting of Smc/ScpAB to ParB/parS loading sites is strictly dependent on engagement of Smc head domains and relies on an open organization of ..
  7. Taylor J, Pastrana C, Butterer A, Pernstich C, Gwynn E, Sobott F, et al. Specific and non-specific interactions of ParB with DNA: implications for chromosome segregation. Nucleic Acids Res. 2015;43:719-31 pubmed publisher
    The segregation of many bacterial chromosomes is dependent on the interactions of ParB proteins with centromere-like DNA sequences called parS that are located close to the origin of replication...
  8. Song D, Rodrigues K, Graham T, Loparo J. A network of cis and trans interactions is required for ParB spreading. Nucleic Acids Res. 2017;45:7106-7117 pubmed publisher
    ..This system depends on a DNA-binding protein ParB, which binds specifically to the centromere DNA sequence parS and to adjacent non-specific DNA over multiple ..
  9. Mysliwiec T, Errington J, Vaidya A, Bramucci M. The Bacillus subtilis spo0J gene: evidence for involvement in catabolite repression of sporulation. J Bacteriol. 1991;173:1911-9 pubmed
    ..Analysis of the deduced amino acid sequence of the spo0J locus indicated that the spo0J gene product contains an alpha-helix-turn-alpha-helix unit similar to the motif found in lambda Cro-like DNA-binding proteins. ..