Gene Symbol: hprK
Description: HPr kinase/phosphorylase
Species: Bacillus subtilis subsp. subtilis str. 168
Pompeo F, Granet Y, Lavergne J, Grangeasse C, Nessler S, Jault J, et al
. Regulation and mutational analysis of the HPr kinase/phosphorylase from Bacillus subtilis. Biochemistry. 2003;42:6762-71 pubmed
..Gram-positive bacteria, catabolite repression is mediated by a bifunctional enzyme, the HPr kinase/phosphorylase (HprK/P)...
Poncet S, Mijakovic I, Nessler S, Gueguen Chaignon V, Chaptal V, Galinier A, et al
. HPr kinase/phosphorylase, a Walker motif A-containing bifunctional sensor enzyme controlling catabolite repression in Gram-positive bacteria. Biochim Biophys Acta. 2004;1697:123-35 pubmed
..repression (CCR) in Gram-positive bacteria is regulated by the bifunctional enzyme HPr kinase/phosphorylase (HprK/P)...
Lavergne J, Jault J, Galinier A. Insights into the functioning of Bacillus subtilis HPr kinase/phosphatase: affinity for its protein substrates and role of cations and phosphate. Biochemistry. 2002;41:6218-25 pubmed
In Bacillus subtilis, carbon catabolite repression is mediated by the HPr kinase/phosphatase (HprK/P) which catalyzes both an ATP-dependent phosphorylation and a dephosphorylation on Ser-46 of either HPr (histidine-containing protein) or ..
Bertram R, W nsche A, Sprehe M, Hillen W. Regulated expression of HPrK/P does not affect carbon catabolite repression of the xyn operon and of rocG in Bacillus subtilis. FEMS Microbiol Lett. 2006;259:147-52 pubmed publisher
HPr kinase/phosphorylase (HPrK/P), a central metabolic regulator in many Gram-positive bacteria, reversibly phosphorylates HPr and Crh, thus controlling their activities as effectors of CcpA predominantly in carbon catabolite repression (..
Meyer F, Jules M, Mehne F, Le Coq D, Landmann J, G rke B, et al
. Malate-mediated carbon catabolite repression in Bacillus subtilis involves the HPrK/CcpA pathway. J Bacteriol. 2011;193:6939-49 pubmed publisher
..The repression strength of target promoters was similar to that observed in steady-state growth conditions, although it took somewhat longer to reach the second steady-state of expression when cells were shifted to malate...
Reizer J, Hoischen C, Titgemeyer F, Rivolta C, Rabus R, Stülke J, et al
. A novel protein kinase that controls carbon catabolite repression in bacteria. Mol Microbiol. 1998;27:1157-69 pubmed
..subtilis, the ptsK mutant is insensitive to transcriptional regulation by catabolite repression. The reported results advance our understanding of phosphorylation-dependent carbon control mechanisms in Gram-positive bacteria. ..
Robinson C, Rivolta C, Karamata D, Moir A. The product of the yvoC (gerF) gene of Bacillus subtilis is required for spore germination. Microbiology. 1998;144 ( Pt 11):3105-9 pubmed
..Two other null mutants in this chromosomal region showed a clear phenotype: the nagA gene is required for growth on N-acetylglucosamine, whereas a null mutation in yvoB (ptsK) affects colony formation from single cells. ..
Kravanja M, Engelmann R, Dossonnet V, Blüggel M, Meyer H, Frank R, et al
. The hprK gene of Enterococcus faecalis encodes a novel bifunctional enzyme: the HPr kinase/phosphatase. Mol Microbiol. 1999;31:59-66 pubmed
..The hprK gene from Enterococcus faecalis was cloned via polymerase chain reaction (PCR) and sequenced...
Galinier A, Kravanja M, Engelmann R, Hengstenberg W, Kilhoffer M, Deutscher J, et al
. New protein kinase and protein phosphatase families mediate signal transduction in bacterial catabolite repression. Proc Natl Acad Sci U S A. 1998;95:1823-8 pubmed
..We here report cloning of the Bacillus subtilis hprK and hprP genes and characterization of the encoded HPr kinase and P-Ser-HPr phosphatase...