Gene Symbol: gabR
Description: GntR family transcriptional regulator
Species: Bacillus subtilis subsp. subtilis str. 168
Okuda K, Ito T, Goto M, Takenaka T, Hemmi H, Yoshimura T. Domain characterization of Bacillus subtilis GabR, a pyridoxal 5'-phosphate-dependent transcriptional regulator. J Biochem. 2015;158:225-34 pubmed publisher
Bacillus subtilis GabR is a transcriptional regulator consisting of a helix-turn-helix N-terminal DNA-binding domain, a pyridoxal 5'-phosphate (PLP)-binding C-terminal domain that has a structure homologous to aminotransferases, and a ..
Park S, Park Y, Lee K. Crystal structure of the C-terminal domain of Bacillus subtilis GabR reveals a closed conformation by ?-aminobutyric acid binding, inducing transcriptional activation. Biochem Biophys Res Commun. 2017;487:287-291 pubmed publisher
Bacillus subtilis GabR (BsGabR) is involved in the ?-aminobutyric acid (GABA) catabolism as a transcriptional regulator, consisting of an N-terminal helix-turn-helix DNA-binding domain and a C-terminal aminotransferase-like (AT-like) ..
Al Zyoud W, Hynson R, Ganuelas L, Coster A, Duff A, Baker M, et al
. Binding of transcription factor GabR to DNA requires recognition of DNA shape at a location distinct from its cognate binding site. Nucleic Acids Res. 2016;44:1411-20 pubmed publisher
..Here, we uncover a new mechanism where the transcription factor GabR simultaneously recognizes two cognate binding sites and the shape of a 29 bp DNA sequence that bridges these sites...
Belitsky B. Bacillus subtilis GabR, a protein with DNA-binding and aminotransferase domains, is a PLP-dependent transcriptional regulator. J Mol Biol. 2004;340:655-64 pubmed
Bacillus subtilis GabR is a member of a poorly characterized but widespread family of chimeric bacterial proteins that have apparent DNA binding and aminotransferase domains...
Okuda K, Kato S, Ito T, Shiraki S, Kawase Y, Goto M, et al
. Role of the aminotransferase domain in Bacillus subtilis GabR, a pyridoxal 5'-phosphate-dependent transcriptional regulator. Mol Microbiol. 2015;95:245-57 pubmed publisher
MocR/GabR family proteins are widely distributed prokaryotic transcriptional regulators containing pyridoxal 5'-phosphate (PLP), a coenzyme form of vitamin B6...