fur

Summary

Gene Symbol: fur
Description: ferric uptake regulation protein
Species: Bacillus subtilis subsp. subtilis str. 168

Top Publications

  1. Gaballa A, Helmann J. Bacillus subtilis Fur represses one of two paralogous haem-degrading monooxygenases. Microbiology. 2011;157:3221-31 pubmed publisher
    Identification of genes regulated by the ferric uptake regulator (Fur) protein has provided insights into the diverse mechanisms of adaptation to iron limitation...
  2. Caux Thang C, Parent A, Sethu R, Maïga A, Blondin G, Latour J, et al. Single asparagine to arginine mutation allows PerR to switch from PerR box to fur box. ACS Chem Biol. 2015;10:682-6 pubmed publisher
    b>Fur family proteins, ubiquitous in prokaryotes, play a pivotal role in microbial survival and virulence in most pathogens...
  3. Helmann J. Specificity of metal sensing: iron and manganese homeostasis in Bacillus subtilis. J Biol Chem. 2014;289:28112-20 pubmed publisher
    ..a model for the coordinate regulation of iron and manganese homeostasis that involves three key regulators: Fur senses iron sufficiency, MntR senses manganese sufficiency, and PerR senses the intracellular Fe/Mn ratio...
  4. Bsat N, Herbig A, Casillas Martinez L, Setlow P, Helmann J. Bacillus subtilis contains multiple Fur homologues: identification of the iron uptake (Fur) and peroxide regulon (PerR) repressors. Mol Microbiol. 1998;29:189-98 pubmed
    b>Fur (ferric uptake regulator) proteins control iron uptake in many Gram-negative bacteria. Although Fur homologues have been identified in Gram-positive bacteria, their roles in gene regulation are unknown...
  5. Ma Z, Faulkner M, Helmann J. Origins of specificity and cross-talk in metal ion sensing by Bacillus subtilis Fur. Mol Microbiol. 2012;86:1144-55 pubmed publisher
    b>Fur (ferric uptake regulator) is the master regulator of iron homeostasis in many bacteria, but how it responds specifically to Fe(II) in vivo is not clear...
  6. Henares B, Kommineni S, Chumsakul O, Ogasawara N, Ishikawa S, Nakano M. The ResD response regulator, through functional interaction with NsrR and fur, plays three distinct roles in Bacillus subtilis transcriptional control. J Bacteriol. 2014;196:493-503 pubmed publisher
    ..The study showed that ResD and NsrR directly control transcription of the ykuNOP operon in the Fur regulon...