ftsZ

Summary

Gene Symbol: ftsZ
Description: cell division protein FtsZ
Species: Bacillus subtilis subsp. subtilis str. 168

Top Publications

  1. Singh J, Makde R, Kumar V, Panda D. A membrane protein, EzrA, regulates assembly dynamics of FtsZ by interacting with the C-terminal tail of FtsZ. Biochemistry. 2007;46:11013-22 pubmed
    b>FtsZ polymerizes to form a dynamic ring structure called the Z-ring at the midcell of bacteria...
  2. Scheffers D. The effect of MinC on FtsZ polymerization is pH dependent and can be counteracted by ZapA. FEBS Lett. 2008;582:2601-8 pubmed publisher
    ..Here, the biochemical characterization of the interaction of MinC and FtsZ from a Gram-positive bacterium, Bacillus subtilis, is reported. B...
  3. Weart R, Nakano S, Lane B, Zuber P, Levin P. The ClpX chaperone modulates assembly of the tubulin-like protein FtsZ. Mol Microbiol. 2005;57:238-49 pubmed
    Summary Assembly of the tubulin-like cytoskeletal protein FtsZ into a ring structure establishes the location of the nascent division site in prokaryotes...
  4. Wu X, Nathoo S, Pang A, Carne T, Wong S. Cloning, genetic organization, and characterization of a structural gene encoding bacillopeptidase F from Bacillus subtilis. J Biol Chem. 1990;265:6845-50 pubmed
  5. Peters P, Migocki M, Thoni C, Harry E. A new assembly pathway for the cytokinetic Z ring from a dynamic helical structure in vegetatively growing cells of Bacillus subtilis. Mol Microbiol. 2007;64:487-99 pubmed publisher
    The earliest event in bacterial cell division is the formation of a Z ring, composed of the tubulin-like FtsZ protein, at the division site at midcell...
  6. Oliva M, Trambaiolo D, L we J. Structural insights into the conformational variability of FtsZ. J Mol Biol. 2007;373:1229-42 pubmed publisher
    b>FtsZ is a prokaryotic homologue of the eukaryotic cytoskeletal protein tubulin and plays a central role in prokaryotic cell division...
  7. Monahan L, Robinson A, Harry E. Lateral FtsZ association and the assembly of the cytokinetic Z ring in bacteria. Mol Microbiol. 2009;74:1004-17 pubmed publisher
    Cell division in bacteria is facilitated by a polymeric ring structure, the Z ring, composed of tubulin-like FtsZ protofilaments...
  8. Bisson Filho A, Discola K, Castellen P, Blasios V, Martins A, Sforça M, et al. FtsZ filament capping by MciZ, a developmental regulator of bacterial division. Proc Natl Acad Sci U S A. 2015;112:E2130-8 pubmed publisher
    Cytoskeletal structures are dynamically remodeled with the aid of regulatory proteins. FtsZ (filamentation temperature-sensitive Z) is the bacterial homolog of tubulin that polymerizes into rings localized to cell-division sites, and the ..
  9. Beall B, Lowe M, Lutkenhaus J. Cloning and characterization of Bacillus subtilis homologs of Escherichia coli cell division genes ftsZ and ftsA. J Bacteriol. 1988;170:4855-64 pubmed
    The Bacillus subtilis homolog of the Escherichia coli ftsZ gene was isolated by screening a B. subtilis genomic library with anti-E. coli FtsZ antiserum. DNA sequence analysis of a 4-kilobase region revealed three open reading frames...

More Information

Publications14

  1. Kr l E, van Kessel S, van Bezouwen L, Kumar N, Boekema E, Scheffers D. Bacillus subtilis SepF binds to the C-terminus of FtsZ. PLoS ONE. 2012;7:e43293 pubmed publisher
    ..Formation of the divisome starts with the polymerization of the tubulin-like protein FtsZ into a ring, the Z-ring...
  2. Krol E, de Sousa Borges A, Kopacz M, Scheffers D. Metal-dependent SpoIIE oligomerization stabilizes FtsZ during asymmetric division in Bacillus subtilis. PLoS ONE. 2017;12:e0174713 pubmed publisher
    ..Absence of Mn2+ from sporulation medium results in a delay of the formation of polar FtsZ-rings, similar to a spoIIE null mutant...
  3. Jindal B, Panda D. Understanding FtsZ assembly: cues from the behavior of its N- and C-terminal domains. Biochemistry. 2013;52:7071-81 pubmed publisher
    b>FtsZ polymerizes to form a cytokinetic ring at the center of a bacterial cell, which engineers bacterial cell division...
  4. Bisson Filho A, Hsu Y, Squyres G, Kuru E, Wu F, Jukes C, et al. Treadmilling by FtsZ filaments drives peptidoglycan synthesis and bacterial cell division. Science. 2017;355:739-743 pubmed publisher
    The mechanism by which bacteria divide is not well understood. Cell division is mediated by filaments of FtsZ and FtsA (FtsAZ) that recruit septal peptidoglycan-synthesizing enzymes to the division site...
  5. Ishikawa S, Kawai Y, Hiramatsu K, Kuwano M, Ogasawara N. A new FtsZ-interacting protein, YlmF, complements the activity of FtsA during progression of cell division in Bacillus subtilis. Mol Microbiol. 2006;60:1364-80 pubmed
    The assembly of ring-like structures, composed of FtsZ proteins (i.e. the Z ring), is the earliest and most essential process in bacterial cytokinesis...