bmrR

Summary

Gene Symbol: bmrR
Description: MerR family transcriptional regulator
Species: Bacillus subtilis subsp. subtilis str. 168

Top Publications

  1. ncbi A protein that activates expression of a multidrug efflux transporter upon binding the transporter substrates
    M Ahmed
    Department of Medicinal Chemistry and Pharmacognosy, University of Illinois, Chicago 60612
    J Biol Chem 269:28506-13. 1994
  2. ncbi Structural basis of multidrug recognition by BmrR, a transcription activator of a multidrug transporter
    E E Zheleznova
    Department of Biochemistry and Molecular Biology, Oregon Health Sciences University, Portland 97201 3098, USA
    Cell 96:353-62. 1999
  3. ncbi Crystal structure of the transcription activator BmrR bound to DNA and a drug
    E E Heldwein
    Department of Biochemistry and Molecular Biology, Oregon Health Sciences University, Portland 97201 3098, USA
    Nature 409:378-82. 2001
  4. ncbi The structural mechanism for transcription activation by MerR family member multidrug transporter activation, N terminus
    Kate J Newberry
    Department of Biochemistry and Molecular Biology, Oregon Health and Science University, Portland, OR 97239 3098, USA
    J Biol Chem 279:20356-62. 2004
  5. pmc Conformational plasticity of the coiled-coil domain of BmrR is required for bmr operator binding: the structure of unliganded BmrR
    Muthiah Kumaraswami
    Department of Biochemistry and Molecular Biology, Center for Biomolecular Structure and Function, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Mol Biol 398:264-75. 2010
  6. pmc Structural contributions to multidrug recognition in the multidrug resistance (MDR) gene regulator, BmrR
    Sharrol Bachas
    Department of Biophysics and Biophysical Chemistry, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 108:11046-51. 2011

Detail Information

Publications6

  1. ncbi A protein that activates expression of a multidrug efflux transporter upon binding the transporter substrates
    M Ahmed
    Department of Medicinal Chemistry and Pharmacognosy, University of Illinois, Chicago 60612
    J Biol Chem 269:28506-13. 1994
    ..The protein product of this open reading frame, BmrR, shows distinct sequence homology to several known bacterial transcription activator proteins, such as MerR and ..
  2. ncbi Structural basis of multidrug recognition by BmrR, a transcription activator of a multidrug transporter
    E E Zheleznova
    Department of Biochemistry and Molecular Biology, Oregon Health Sciences University, Portland 97201 3098, USA
    Cell 96:353-62. 1999
    ..to bind diverse hydrophobic cationic drugs is characteristic of the Bacillus subtilis transcription regulator BmrR, which upon drug binding activates expression of the multidrug transporter Bmr...
  3. ncbi Crystal structure of the transcription activator BmrR bound to DNA and a drug
    E E Heldwein
    Department of Biochemistry and Molecular Biology, Oregon Health Sciences University, Portland 97201 3098, USA
    Nature 409:378-82. 2001
    ..The concentrations of many of these transporters are controlled by transcription regulators, such as BmrR in Bacillus subtilis, EmrR in Escherichia coli and QacR in Staphylococcus aureus...
  4. ncbi The structural mechanism for transcription activation by MerR family member multidrug transporter activation, N terminus
    Kate J Newberry
    Department of Biochemistry and Molecular Biology, Oregon Health and Science University, Portland, OR 97239 3098, USA
    J Biol Chem 279:20356-62. 2004
    ..The crystal structure of a BmrR-TPP(+)-DNA complex provided initial insight into the transcription activation mechanism of the MerR family, which ..
  5. pmc Conformational plasticity of the coiled-coil domain of BmrR is required for bmr operator binding: the structure of unliganded BmrR
    Muthiah Kumaraswami
    Department of Biochemistry and Molecular Biology, Center for Biomolecular Structure and Function, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Mol Biol 398:264-75. 2010
    The multidrug-binding transcription regulator BmrR from Bacillus subtilis is a MerR family member that binds to a wide array of cationic lipophilic toxins to activate the transcription of the multidrug efflux pump gene bmr...
  6. pmc Structural contributions to multidrug recognition in the multidrug resistance (MDR) gene regulator, BmrR
    Sharrol Bachas
    Department of Biophysics and Biophysical Chemistry, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 108:11046-51. 2011
    ..However, MD recognition in BmrR is supported by a small, rigid drug-binding pocket...